Temporary Research Associate / Scientist

Temporary Research Associate / Scientist

Headquartered in Carlsbad, California, and with offices in Boston, Massachusetts, and Dublin, Ireland, Ionis has been at work for more than three decades discovering medical breakthroughs that have redefined life for people with serious diseases. We're pioneers in RNA-targeted medicines, and our platform continues to revolutionize drug discovery and transform lives for patients with unmet needs. With multiple marketed medicines and a leading pipeline in neurology, cardiology and select areas of high patient needs, we continue to drive innovation in RNA therapies in addition to advancing new approaches in gene editing to provide greater value to patients and are well positioned financially to deliver on our strategic goals. At Ionis, we pride ourselves on cultivating a challenging, motivating and rewarding environment that fosters innovation and scientific excellence. We know that our success is a direct result of the exceptional talents and dedication of our employees. With an unprecedented opportunity to change the course of human health, we look to add diverse individuals, skill sets and perspectives to our exceptional team. We continue to invest time, money and energy into making our onsite, hybrid and remote work environments a place where solid and lasting relationships are built and where our culture and employees can thrive. We're building on our rich history, and we believe our greatest achievements are ahead of us. If you're passionate about the opportunity to have meaningful impact on patients in need, we invite you to apply and join us. Experience and contribute to our unique culture while you develop and expand your career!

Temporary Research Associate / Scientist Summary

We are seeking a highly motivated and skilled research associate or scientist to join our medicinal chemistry team. Experience with oligonucleotide chemistry is highly preferred. The successful candidate will play a key role in the development and optimization of oligonucleotide conjugates to enable targeted delivery of nucleic acid therapeutics.

Responsibilities

• Synthesis of chemically modified oligonucleotides on oligonucleotide synthesizers.
• Design, execute and optimize bioconjugation strategies for linking ASOs, siRNAs, or other oligonucleotides to antibodies, peptides and other ligands with a variety of bioconjugation chemistries.
• Purification of oligonucleotides conjugates utilizing common HPLC methodologies.
• Characterize conjugates using a variety of analytical techniques, including chromatography, and mass spectrometry.
• Collaborate cross-functionally with colleagues in medicinal chemistry, cell biology, and drug discovery to advance project objectives related to targeted delivery.
• Data analysis, troubleshooting, and contributing to project planning and strategy discussions.

Requirements

• Bachelor's or Master's degree in Biochemistry, Chemistry, or related field with 2+ years of laboratory experience in bioconjugation.
• Experience in nucleoside/oligonucleotide synthesis and purification
• Experience with purification techniques (e.g., ion exchange, reverse-phase, and size-exclusion chromatography)
• Proficiency with and mechanistic understanding of common bioconjugation chemistries including SPAAC and Maleimide.
• Proficiency in common analytical techniques including HPLC and mass spectrometry.
• Ability to work independently, prioritize tasks, and adapt to changing project needs in a fast-paced research environment.
• Excellent communication skills and a collaborative mindset, with the ability to effectively interact with multidisciplinary teams.