Associate Director, Clinical Pharmacology

Associate Director, Clinical Pharmacology United States - Massachusetts - Cambridge United States - Connecticut - Groton United States - Pennsylvania - Collegeville United States - New York - New York City We’re in relentless pursuit of breakthroughs that change patients’ lives. We innovate every day to make the world a healthier place. To fully realize Pfizer’s purpose – Breakthroughs that change patients’ lives – we have established a clear set of expectations regarding “what” we need to achieve for patients and “how” we will go about achieving those goals. Pfizer Research & Development serves as the beating heart of Pfizer's trailblazing product pipeline, the essence of our mission to bring life‑changing medicines to the world. Pfizer offers competitive compensation and benefits programs designed to meet the diverse needs of our colleagues.

ROLE SUMMARY

Our Clinical Pharmacology Team is looking for an Associate Director to support an internal medicine portfolio. The role involves leading the clinical pharmacology and MIDD components of clinical plans, providing expertise to project teams and regulatory interactions, and applying innovative methods to integrate pharmacokinetics, pharmacodynamics, patient characteristics, and disease states for rational development strategies, optimal study designs, and dosage regimen selections.

ROLE RESPONSIBILITIES

Act as Clinical Pharmacology representative on Clinical Sub Team, Development Team, and other multifunctional teams as appropriate. Provide expertise, leadership, and deliverables of clinical pharmacology for assigned projects. Design and execute clinical pharmacology plans and implement best practices on project teams. Work closely with other disciplines to ensure sufficient preclinical PK/PD knowledge exists to underwrite safe human administration and establish predictive models prior to First‑In—Human studies. Plan and oversee clinical pharmacology aspects at the project level (e.g., development plan, PK/PD analysis, biomarker strategies). Plan and oversee study‑level activities including protocol authoring, clinical phase oversight, and reporting. Ensure appropriate dose‑range finding strategies for optimal doses and dosage regimens. Accountable for design and implementation of End‑to‑End MIDD plan that conforms with best practices. Use innovative analytical methods to integrate knowledge of PK, PD, patient characteristics, and disease states to optimize doses, dosage regimens, and study designs. Provide End‑to‑End clinical pharmacology contributions to regulatory documents (e.g., briefing documents, regulatory queries, investigator’s brochures, IND, NDA/MAA). Develop new methodologies through internal and/or external collaborations with world‑leading experts. Coach less experienced colleagues and team members. Stay abreast of literature, regulatory guidelines, and internal guidances and SOPs. Influence external environment through publications, presentations, and representation at scientific societies and industrial consortiums.

QUALIFICATIONS

Demonstrated leadership experience: influence and collaborate with peers, develop and coach others, and oversee work of colleagues to achieve meaningful outcomes. Strong quantitative skills and expertise in mechanistic PK/PD modeling, systems pharmacology, literature meta‑analyses, population modeling, and clinical trial simulations using NONMEM, R, etc. MD, PhD, PharmD, or equivalent training/experience in pharmacokinetics, pharmacometrics, clinical pharmacology, engineering, or related discipline. At least 1 year industry experience in clinical pharmacology and/or clinical PK/PD and/or pharmacometrics/systems pharmacology (minimum 5 years preferred). Intimate knowledge of drug development and experience applying quantitative pharmacology approaches to knowledge integration. Excellent written and verbal communication skills. Demonstrated presentation skills. Ability to attend global meetings periodically across different time zones. Other Job Details Eligible for Employee Referral Bonus: Yes Work Location Assignment: This is a hybrid role requiring you to live within commuting distance and work on‑site an average of 2.5 days per week or more as needed. Annual base salary ranges from $139,100 to $231,900. Eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 17.5% of base salary and share‑based long‑term incentive program. Benefits include 401(k) with matching contributions, additional retirement savings contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits such as medical, prescription drug, dental, and vision coverage. Relocation assistance may be available based on business needs and eligibility. Candidates must be authorized to be employed in the United States by any employer. U.S. work visa sponsorship (such as TN, O-1, H‑1B, etc.) is not available for this role now or in the future. Sunshine Act Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws. If you are a licensed physician and incur recruiting expenses that Pfizer pays or reimburses, your name, address, and payment amount will be reported to the government. If you have questions about this matter, please contact your Talent Acquisition representative. EEO & Employment Eligibility Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or expression, national origin, disability or veteran status. Pfizer complies with all applicable laws governing nondiscrimination in employment and employment eligibility verification. Pfizer is an E‑Verify employer. This position requires permanent work authorization in the United States. For accessibility assistance with the Pfizer careers website or application process, email View email address on click.appcast.io. To learn more about acceptable and prohibited uses of AI during the recruitment process, please review our candidate AI‑use guidelines available on Pfizer Careers. #J-18808-Ljbffr Pfizer, S.A. de C.V