Postdoctoral Fellow-MSH-30001-336

Postdoctoral Fellow in novel gene-based therapeutic approaches to Alzheimer’s Disease

Immediately available, NIH funded

Description: 

The Alison Goate laboratory in the Departments of Genetics and Genomic Sciences and of Neuroscience at the Icahn School of Medicine at Mount Sinai in New York City is currently looking for highly skilled and motivated molecular and cell biologists to be the drivers of our efforts to translate the human genetics of Alzheimer’s disease (AD) into effective preventative and therapeutic interventions. Core areas of focus will be translating genetics and human biology observations into both in vitro (induced pluripotent stem cell models) and in vivo systems (mouse models) to understand innate immune modifiers of AD pathogenesis. In particular, the Goate lab concentrates on identifying human genetic variants associated with AD and dissecting the molecular, cellular, and tissue-level mechanisms by which these variants and the associated genes (e.g., APOE, TREM2, SPI1/PU.1, MEF2C, MS4A) modulate disease risk, with a major focus on the role of microglial cell function (e.g., phagocytic clearance of cholesterol-rich cellular debris) in the maintenance of brain tissue homeostasis during aging and in disease conditions. In vivo studies are being performed to study the impact of risk genes on AD pathology and to test novel therapeutic approaches. In addition, the Goate lab also investigates how the human genetics of the 17q21.31 “MAPT/tau” locus contributes to mechanisms underlying Tauopathy, and translating this work into effective preventative and therapeutic interventions. Core areas of focus will be translating genetics and human biology observations into in vitro (induced pluripotent stem cell models) models to understand the role of 17q21.31 on disease pathogenesis. The candidate will join a multidisciplinary and highly collaborative research team that includes geneticists, computational biologists, immunologists, neuroscientists, and physician-scientists at the Ronald M. Loeb Center for Alzheimer’s Disease, as well as at other leading US and European academic institutions and biopharmaceutical companies.

The candidate will join a multidisciplinary and highly collaborative research team that includes geneticists, computational biologists, immunologists, neuroscientists, and physician-scientists at the Ronald M. Loeb Center for Alzheimer’s Disease, as well as at other leading US and European academic institutions and biopharmaceutical companies.

Qualifications and Skills

• Ph.D. in Biology, Neuroscience, Immunology, or related field with deep expertise in molecular and cellular biology techniques

• Strong research experience in animal models of neurodegeneration (preferred)
• Strong research experience in gene therapy approaches to neurodegeneration in vivo (preferred)
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• Strong research experience in human iPSC technology and targeted genome editing in vitro (preferred)
• - or -
• Strong research experience in high-throughput technologies (e.g., NGS and CyTOF) for bulk and single-cell transcriptomics, epigenomics, lipidomics and/or proteomics (preferred)
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• Strong research experience in functional genomics (e.g., siRNA, shRNA, CRISPR/Cas9, and chemogenomic) screens (preferred)
• Knowledge of experimental design
• Statistical and quantitative analysis skills
• Basic bioinformatics skills (preferred)
• Self-motivated and highly dedicated
• Effective organizational and prioritization skills
• Effective oral, written, and interpersonal communication skills

• Ability to work both independently as well as collaboratively in a multidisciplinary environment

Strength through Unity and Inclusion

The Mount Sinai Health System is committed to fostering an environment where everyone can contribute to excellence. We share a common dedication to delivering outstanding patient care. When you join us, you become part of Mount Sinai’s unparalleled legacy of achievement, education, and innovation as we work together to transform healthcare. We encourage all team members to actively participate in creating a culture that ensures fair access to opportunities, promotes inclusive practices, and supports the success of every individual.

At Mount Sinai, our leaders are committed to fostering a workplace where all employees feel valued, respected, and empowered to grow. We strive to create an environment where collaboration, fairness, and continuous learning drive positive change, improving the well-being of our staff, patients, and organization. Our leaders are expected to challenge outdated practices, promote a culture of respect, and work toward meaningful improvements that enhance patient care and workplace experiences. We are dedicated to building a supportive and welcoming environment where everyone has the opportunity to thrive and advance professionally. Explore this opportunity and be part of the next chapter in our history.

About the Mount Sinai Health System:

Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 48,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time — discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it. Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients’ medical and emotional needs at the center of all treatment. The Health System includes more than 9,000 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Report's Best Hospitals, receiving high "Honor Roll" status, and are highly ranked: No. 1 in Geriatrics, top 5 in Cardiology/Heart Surgery, and top 20 in Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. U.S. News & World Report’s “Best Children’s Hospitals” ranks Mount Sinai Kravis Children's Hospital among the country’s best in several pediatric specialties. The Icahn School of Medicine at Mount Sinai is ranked No. 11 nationwide in National Institutes of Health funding and in the 99th percentile in research dollars per investigator according to the Association of American Medical Colleges. Newsweek’s “The World’s Best Smart Hospitals” ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally.

Equal Opportunity Employer

The Mount Sinai Health System is an equal opportunity employer, complying with all applicable federal civil rights laws. We do not discriminate, exclude, or treat individuals differently based on race, color, national origin, age, religion, disability, sex, sexual orientation, gender, veteran status, or any other characteristic protected by law. We are deeply committed to fostering an environment where all faculty, staff, students, trainees, patients, visitors, and the communities we serve feel respected and supported. Our goal is to create a healthcare and learning institution that actively works to remove barriers, address challenges, and promote fairness in all aspects of our organization.

Compensation

The Mount Sinai Health System (MSHS) provides salary ranges that comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $72500 - $80000 Annually. Actual salaries depend on a variety of factors, including experience, education, and operational need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.