Director, Medical Affairs Strategic Operations

Immatics is committed to making a meaningful impact on the lives of patients with cancer. We are the global leader in precision targeting of PRAME, a target expressed in more than 50 cancers. Our cutting-edge science and robust clinical pipeline form the broadest PRAME franchise with the most PRAME indications and modalities, spanning TCR T-cell therapies and TCR bispecifics. Why Join Us? Innovative Environment: Help to pioneer advancements in cancer immunotherapy. Collaborative Culture: Be part of a diverse team dedicated to your professional growth. Global Impact: Contribute to therapies that make a lasting impact on patients globally. Role Overview: The Director, Medical Affairs Operations will lead the operational strategy and execution of Medical Affairs activities with strong business acumen, and an established history of executing and driving medical launch readiness. As a core member of the USMA Leadership Team, this role ensures that strategy is translated into coordinated, high-impact execution across cross-functional stakeholders. This role will partner closely across internal teams and external stakeholders to ensure compliant, efficient, and scalable solutions that support medical strategy, launch readiness, and scientific exchange in our rapidly evolving PRAME franchise. Reports to: Vice President, Medical Affairs Location: Remote Salary Range: $200,000 - $240,000 Basic Qualifications: Bachelor's degree in Life Sciences, Pharmacy, Nursing, Business Administration, or a related discipline required. 10 years of experience in Medical Affairs or related functions within biotech or pharmaceutical industries. Preferred Qualifications: Advanced degree preferred (MBA, PharmD, PhD, MS, or equivalent). Experience supporting cell therapy, oncology, immunology, or rare disease programs. Experience with Medical Affairs technologies (e.g., Veeva CRM, Veeva Vault MedComms, publication management, grant management systems). Experience working in the Medical Affairs function, including scientific communications, external engagement, medical congresses, medical compliance, and data dissemination. Experience creating strong partnerships across Medical, Commercial, Regulatory and G&A functions. Strong strategic planning, project management, operational execution, and ability to thrive in a fast-paced biotech environment. Strategic thinker with hands-on execution capability. Excellent communication and stakeholder management skills. Vendor management experience (scope, quality, timelines, budget, performance) Experience launching new products In this Role You Will: Strategic Operations Leadership & Execution Management Translate Medical Affairs strategy into aligned goals and cross-functional plans spanning scientific engagement, communications, evidence generation, and launch readiness; enable alignment between US and Global strategies and drive clarity on priorities and execution. Partner with the Head of Medical Affairs, Global Commercialization, US Commercial and Market Access, Regulatory and Clinical Development stakeholders to ensure strategic alignment and coordinated execution. Lead complex, cross-functional medical workstreams spanning launch readiness, scientific communications, congress strategy, HEOR/IEP coordination, and external engagement strategy for new product launches, indication expansions, and lifecycle management. Establish a clear operating rhythm to facilitate strategic planning, budgeting, and business reviews and align with enterprise and global strategic planning efforts. Serve as trusted advisor to Medical Affairs Leadership by synthesizing complex clinical, scientific, and market insights into actional recommendations to enable timely decision making, prioritization, planning, and resourcing of Medical Affairs priorities. Strategy & Analytics Champion continuous innovation in US Medical Affairs operations, advance new ways of working including AI-enabled insights and data-drive planning to drive simplification, scalability and improved decision Medical Affairs processes. Collaborate on implementation and governance of digital platforms for insights management, medical planning, and content review. Evolve US Medical Affairs governance frameworks, including Medical Review Committees (MRC), and assess how to effectively coordinate across various enterprise forums Partner with Regulatory and Compliance to ensure compliance with US regulatory standards (FDA, GVP, PhRMA Code), internal policies, and legal requirements. Develop and maintain dashboards and KPIs to measure Medical Affairs performance Analyze operational data to identify trends, risks, and improvement opportunities Program & Project Management Lead end-to-end execution of grants, investigator-initiated trials, sponsorships, advocacy, and congress programs Oversee complex, cross-functional projects, including risk management and executive reporting Support development of scalable Medical Affairs plans aligned to launch and growth priorities Financial & Vendor Management Manage Medical Affairs budget, including forecasting and financial planning Lead vendor strategy, selection, and negotiations to optimize value and performance Qualified candidates will participate in a structured interview process, which includes: An initial recruiter phone screen (conducted via video) A recruiter-facilitated introduction and interview with the hiring leader and key stakeholders (via video) A final-stage interview, which may include an in-person meeting at our U.S. Headquarters in Houston, TX What do we offer? At Immatics, we believe in investing in our team’s health, safety and well-being. Here’s what you can expect if you join Immatics: Comprehensive Benefits: Competitive rates for Health, Dental, and Vision Insurance 4 weeks of vacation, granted up front each year and prorated for first and last year of employment. 12 company paid holidays 7 days of sick time 100% employer-paid life insurance up to at 1x annual salary, up to one hundred thousand dollars 100% employer-paid short- and long-Term disability coverage 401(k) with immediate eligibility and company match… The company will match 100% of your contributions up to 3% of your base salary for the first two years of employment, 4% for years 2-3 of employment, and up to 5% of your salary from the fourth year onward of continued employment. Partially paid parental leave for eligible employees. Additional voluntary employee-paid benefits and services, including accident, hospital indemnity, and critical illness insurance, as well as identity theft protection and pet insurance. Equal Employment Opportunity We are an equal opportunity employer and are committed to building a diverse and inclusive workplace. We consider all qualified applicants for employment without regard to race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity or expression, national origin, ancestry, age, marital status, disability, genetic information, veteran status, or any other status protected by applicable law. Reasonable Accommodations We are committed to providing reasonable accommodations to individuals with disabilities and to applicants with sincerely held religious beliefs, practices, or observances. If you require assistance or accommodation during the application or interview process, please contact us at View email address on click.appcast.io. Work Authorization Applicants must be authorized to work in the United States without the need for current or future sponsorship. Visa sponsorships may be available for certain roles. Pre-Employment Requirements Employment is contingent upon successful completion of a background check, reference checks and pre-employment drug screening, where permitted by applicable law. For certain roles, additional screenings such as a credit check or motor vehicle record review may be required, where job-related and consistent with business necessity. Immatics is committed to making a meaningful impact on the lives of patients with cancer. We are the global leader in precision targeting of PRAME, a target expressed in more than 50 cancers. Our cutting-edge science and robust clinical pipeline form the broadest PRAME franchise with the most PRAME indications and modalities, spanning TCR T-cell therapies and TCR bispecifics. We are only accepting digital applications via the application form of each position. For general inquiries on recruiting topics, please write a message to View email address on click.appcast.io for German recruiting topics or View email address on click.appcast.io for US recruiting topics. Don't see the job you are looking for? Drop off your contact information and resume and we will reach out to you if we see a job that might be a good fit.