HEOR Modeling Director (Remote-Eligible)

Job Summary Vertex is seeking a talented and motivated individual with the desire to be part of a highly innovative company aimed at transforming the lives of people with serious diseases. The role is a Director within the Modeling Center of Excellence (CoE), providing strategic and technical modeling support to the HEOR, Market Access & Pricing, and the broader commercial organization. The Director will lead the team that supports HEOR disease/asset teams in developing health economic models, including those that provide foundations for HTA submissions and early models to inform evidence generation needs. The role is flexible in location (in‑person, hybrid, or remote). Key Responsibilities Set the direction for modeling strategy across one or more therapeutic areas or pipeline assets. Provide leadership and support to the HEOR modeling team as they develop and roll out economic models to support product value strategy. Lead the development of global cost‑effectiveness and budget‑impact models, and associated materials. This may involve in‑house model development as well as managing and validating work conducted by external vendors. Conduct model trainings and support regional teams in local adaptation and development of HTA submissions, and continue support during negotiations with reimbursement authorities. Provide thought leadership on economic modeling to support strategic plans and evidence generation activities. Provide input into the design and interpretation of evidence generation studies needed to support economic models. Offer subject‑matter expertise to cross‑functional partners to support understanding and appropriate application of relevant HEOR evidence in access/reimbursement strategies. Present research findings at scientific congresses and participate in the development of high‑quality, peer‑reviewed publications. Minimum Qualifications Advanced degree in health economics or a related discipline (e.g., mathematics, statistics, economics, epidemiology) and typically 10 years of relevant experience in HEOR, or equivalent education and experience. Previous supervisory or management experience. Extensive experience designing and developing health economic models, preferably supporting HTA submissions and reimbursement negotiations. Excellent communication skills with strong oral and written presentation abilities. Ability to manage complexity and ambiguity in a highly matrixed, fast‑paced environment. Pay Range $204,000 – $306,000 per year, with eligibility for annual bonus and equity awards. Some roles may also be eligible for overtime pay in accordance with federal and state requirements. Benefits Vertex offers inclusive market‑leading benefits that support employees at all career stages, including medical, dental, and vision coverage; generous paid time off; a week‑long company shutdown in the summer and winter; educational assistance such as student loan repayment; a commuting subsidy; charitable donation matching; 401(k) participation; and more. EEO Statement Vertex is a global biotechnology company committed to equal employment opportunity and non‑discrimination for all employees and qualified applicants. The company will make reasonable accommodations for qualified individuals with known disabilities in the hiring process and for performing essential functions of the position. Vertex is an E‑Verify Employer in the United States. #J-18808-Ljbffr Vertex Pharmaceuticals Inc (US)