Sr. Scientist III - Computational Biology

MacroGenics is a leader in the discovery and development of innovative medicines that utilize our next generation antibody-based technologies.â Our team of 150 dedicated individuals is advancing a pipeline of product candidates to treat patients with cancer. Our products and platforms have attracted multiple partnerships with leading pharmaceutical and biotechnology companies around the globe.

The Company considers its employees to be its most valuable asset and we are committed to providing opportunities for individuals to learn and grow as a means to further their professional development. MacroGenics corporate culture promotes an atmosphere of innovation open communication and teamwork where employees can see firsthand how they contribute to the success of the organization.

Summary of Position

We are seeking a highly motivated and intellectually curious Computational Biologist to join our Translational Bioinformatics group. Operating in a highly collaborative and dynamic environment this role is designed for a hands-on builder who thrives on high-quality biological data science that bridges biology and the clinic. You will serve as a vital technical partner translating raw data (genomics proteomics flow cytometry pathology) into actionable biological and clinical insights that drive our pipeline forward. The ideal candidate possesses a deep understanding of quantitative data science a strong foundation in oncology or immunology and a proven track record of writing clean scalable code to answer complex therapeutic questions.

Responsibilities and Job Duties:

• Multi-Omic Integration: Lead the technical execution and integration of diverse datasets across multiple pipelines. Manage data ingestion from external CROs and internal labs combining internal high-dimensional datasets (Flow Cytometry Digital Pathology) with large-scale molecular profiling data (Genomics Transcriptomics Proteomics).
• High-Performance Computing: Build scale and optimize processing pipelines within Cloud Computing to efficiently manage high-dimensional biomarker measurements.
• Provenance and reproducibility: Enforce strict version control containerization and rigorous documentation to ensure all analyses are fully reproducible auditable and transferable across the Translational Medicine team.
• Algorithmic Insight & Custom Analysis : Evaluate standard methodologies identify limitations and develop maintain or modify custom scripts and computational tools to address complex biological questions.
• Data Processing & Reporting: Translate raw complex multi-omic data into clear high-fidelity scientific data packages and executive-ready visualizations that support informed decision-making related to clinical programs and asset development. Build maintain and document robust reproducible code infrastructure to streamline data extraction enabling rapid-turnaround on cross-functional reporting.
• Cross-Functional Collaboration: Partner closely with Clinical Development Biostatistics and Translational Medicine colleagues to co-create data analysis strategies validate clinical hypotheses and design robust translational frameworks.

Qualifications

Education and Experience

Sr. Scientist I

• PhD in a quantitative field (Computational Biology Bioinformatics Genetics Genomics Biophysics Physics or a related discipline).
• 0 2 years of full-time post-PhD experience (academic or industry) demonstrating independent scientific project ownership cross-functional teamwork and navigating a fast-paced environment.

Sr. Scientist II

• PhD in a quantitative field (Computational Biology Bioinformatics Genetics Genomics Biophysics Physics or a related discipline).
• 3 years of full-time post-PhD experience (academic or industry) demonstrating independent scientific project ownership cross-functional teamwork and navigating a fast-paced environment.

Knowledge Skills and Abilities

• Experience across standard modern biological data types including gene expression genome sequencing mutational profiling and proteomics.
• Demonstrated comfort and autonomy working within Cloud Computing environments (AWS Google Cloud) and/or traditional Linux High-Performance Computing (HPC) cluster infrastructures.
• Advanced proficiency in Python for data wrangling statistical analysis and data visualization. Experience with best software development practices including rigorous documentation testing and version control (git).
• Ability to write robust production-quality code completely independent of AI or agentic coding assistants. Deep understanding of the algorithmic basis behind common sequencing and data analysis tools.
• Demonstrated evidence of building published software.

S upervisory Responsibilities:

None

Preferred Qualification

• Prior hands-on experience working within Oncology or Immunology pathways target identification or biomarker discovery.
• Prior hands-on experience with AI/ML-enabled image analysis workflows.
• 2 years working within a Biotech Pharma or structured translational research environment with cross-functional interactions.
• Familiarity with or exposure to agentic coding platforms.
• Experience handling data hand-offs and quality control from external CROs and proteomics/genomics vendors.

Additional Information

Anticipated Start Date: This position is expected to begin in and may not be able to start prior to January 2027.

The annual rate of pay for this position ranges from $132000 - $201300 for Sr. Scientist II and $115600 $176300 for Sr. Scientist I. For non-exempt roles and according to applicable regulations there may be the possibility for overtime pay. This role is eligible for the Companys discretionary bonus and discretionary equity incentives. Eligible employees may participate in the Companys benefits programs including medical / dental / vision / prescription coverage employee wellness resources 401(k) plan with employer match access to an Employee Stock Purchase Plan (ESPP) paid time off & paid parental leave benefits and disability benefits.

The annual pay rate range is described in good faith and the Company believes is the range of possible compensation for this role at the time of this posting depending on the candidates experience qualifications geographic location and other factors permitted by law. The Company may ultimately pay more or less than the posted range and this range may be modified in the future. No amount is considered to be wages or compensation until such amount is earned vested and determinable under the terms and conditions of the applicable policies and plans. The amount and availability of any bonus commission benefits or any other form of compensation and benefits that are allocable to a particular employee remains in the Companys sole discretion unless and until paid and may be modified at the Companys sole discretion consistent with the law.

Statement

MacroGenics is proud to be an equal opportunity employer. Employment selection and related decisions are made without regard to race color national origin sex gender identity sexual orientation religion age disability protected veteran status or any other characteristic protected by federal state or local law. We are committed to working with and providing reasonable accommodation to individuals with disabilities. If because of a medical condition or disability you need a reasonable accommodation for any part of the employment process please email or call and/or 711 for TTD/TTY service.

Required Experience:

Senior IC