Director / Senior Director Global Supply Chain Planning

Company Overview Beam Therapeutics is a biotechnology company committed to establishing the leading, fully integrated platform for precision genetic medicines. To achieve this vision, Beam has assembled a platform with integrated gene editing, delivery and internal manufacturing capabilities. Beam’s suite of gene editing technologies is anchored by base editing, a proprietary technology that is designed to enable precise, predictable and efficient single base changes, at targeted genomic sequences, without making double‑stranded breaks in the DNA. This has the potential to enable a wide range of therapeutic editing strategies that Beam is using to advance a diversified portfolio of base editing programs. Beam is a values‑driven organization committed to its people, cutting‑edge science, and a vision of providing life‑long cures to patients suffering from serious diseases. Position Overview The Global Supply Chain Planning & Network Strategy leader will be responsible for the supply and raw material planning function, supply network design and optimization strategy, inventory ownership and ensuring a strong supply and raw materials plan handoff to internal and external partners. He/she will be accountable to ensure uninterrupted supply of clinical and future commercial products via Beam’s Clinical S&OP process. This role will report to the VP of Supply Chain and partner with leadership in TechOps, ClinOps, Finance, CMC and Program Teams to lead short‑term integrated production and raw materials planning and long‑range strategic supply chain planning of Beam’s product portfolio. This role will partner with Patient Supply to secure clinical supply needs and with Commercial, CMC, Engineering and PD for commercial supply chain design and capabilities of late‑stage clinical development programs. This role will be accountable for designing and implementing core capabilities that drive proactive modeling and decision analysis of supply network and product strategy including governance, S&OP business processes and technology to support this work. The role will be responsible for developing and executing a global inventory management program to ensure raw and critical material availability at Beam NC & CDMO mfg sites. The role will be integral to enhancing site planning and scheduling capabilities at Beam’s mfg site in Durham, NC and partnering with SAP business lead on further advancing technology capabilities. The ideal candidate will have a demonstrated track record of leading in a dynamic environment. They will also possess the ability to successfully interface with multidisciplinary teams and build strong cross‑functional relationships. Responsibilities Develop and implement supply chain analytics, planning, and resilience processes and policy across the global supply chain for all stages of the product lifecycle. Oversee and manage global end to end supply planning and network design as Beam transitions from clinical to commercial stage company over next few years. Ensures appropriate inventory, including design/policy for Raw and Critical Materials (pDNA, mRNA, gRNA, mAb, lipids), Drug Substance, Bulk Drug Product, and Finished Drug Product. Oversee and manage S&OP process. Collaborate cross‑functionally with ClinOps and Program teams to ensure accurate demand forecasts and scenarios/analytics. Responsible for supply network analysis to support tactical and strategic decision making. Coordinate with Finance, Program Teams, CMC and PD to ensure robust modeling of product and network scenarios to support decision‑making in governance forums. Perform risk‑based review of supply chain in order to determine appropriate inventory levels. Communicate demand uncertainties or risks and develop options for optimizing supply network capacity and capabilities. Deliver a response plan for disruptive challenges. Ensure that plan and capabilities of each CDMO and suppliers are adapted to minimize the risk of disruption and deliver an effective response to ensure resilience. Ensure optimal economics, and adequate supply chain security in partnership with Finance for Budget, LRP and capital planning processes. Oversee team to develop supply chain strategies, bringing integrated solutions to the production network. Hire, develop and mentor staff as needed. Direct activities of all functions involved in planning, warehousing, logistics to ensure control of materials from the receipt of raw materials to the delivery of the finished product including inventory controls. Oversee and publish metrics to reflect the effectiveness and efficiency of department activities including supply chain KPIs on inventory, responsiveness and costs. Implement KPIs that drives accountability and improvement in both operational and financial metrics. Partner with NC Mfg to implement standardized site planning and scheduling processes and procedures. Participate in the design & implementation of SAP Phase 3 and IT roadmap in preparation for commercial launch. Other duties as assigned. Qualifications BS/BA degree in Business, Science, Engineering or related field with 15+ years of experience in global supply chain from pharma, biotech or cell & gene therapy companies. Prior drug development, manufacturing, clinical operations experience is a plus. Master’s degree or MBA preferred. Final title/scope of role will be commensurate with experience. Prior management skills with leadership experience building and sustaining global teams. Passion for patients, collaborative and effective leader. Advanced knowledge of contracts, negotiation, vendor management. Knowledge of practical implications of Sarbanes‑Oxley controls. Knowledge of continuous improvement methodologies and tools. Strong organizational and facilitation skills, with high degree of customer focus. Focuses on immediate and urgent business needs while driving long term strategic plans and capability & organizational development. Provides strategy, vision and direction regarding issues that may have company‑wide impact. Requires in‑depth knowledge of the functional area, business strategies, and the company’s goals. Possesses industry‑leading knowledge of sourcing direct materials. Expertise and track record in manufacturing and supply chain execution and oversight. Expert in standing up a formal S&OP process. Extensive experience in supply chain planning, SAP ERP system, capacity modeling, supply network strategy and optimization. Expertise and proven track record in supply chain risk management. Possesses in‑depth knowledge of industry and system best practices. Solid knowledge of regulatory requirements, regulatory guidances, including pharmaceutical GMPs and ICH guidance. Current on Biopharma supply chain, manufacturing technologies, supplier network, CMO network, performance and capacity. Possesses understanding and application of principles, concepts, practices and standards for DS and DP manufacturing in the biopharma industry. Strong communication, negotiation, and interpersonal skills. Strong analytical skills and ability to clearly communicate at tactical and strategic level with team and Sr Management. Ability to work in a dynamic and challenging environment. Some travel may be required. Must be able to work onsite, not a remote role. The salary range below reflects the full‑time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, education, scope of job, internal comparisons, and market data. Beam Pay Range

$260,000—$320,000 USD

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