Senior Site Contracts Manager (Sponsor Dedicated /Remote - US Based)

Senior Site Contracts Manager (Sponsor Dedicated /Remote – US Based)

Syneos Health® is a leading fully-integrated life sciences services organization built to accelerate customer success. We partner with innovators at every point across the drug development and commercialization continuum, helping them navigate complexity, anticipate change and accelerate progress.


Our Clinical Solutions team members act with a drug development mindset, applying their years of experience and deep expertise to truly understand customer needs and represent those in the solutions we shape.


Whether you join us in a Functional Service Provider partnership or a Full-Service environment, you’ll collaborate with passionate problem solvers, innovating as a team to help our customers achieve their goals. We are agile and driven to deliver – for one another, our customers, and, most importantly, for those in need.


Discover what your 25,000 future colleagues already know:


Why Syneos Health
• We are passionate about developing our people, through career development and progression; supportive and engaged line management; technical and therapeutic area training; peer recognition and total rewards program.
• We are committed to building an inclusive culture – where you can authentically be yourself. Central to this is our purpose – Driven to Deliver – which captures the passion of our colleagues to show up each day and shape solutions that have the ability to dramatically impact someone’s life.
• We are continuously building the company we all want to work for and our customers want to work with. Why? Because we know that when we bring together smart colleagues from across the world, we can shape the future of healthcare, driving impact for customers and defining the pace of patient progress.

Job Responsibilities

Senior Site Contracts Manager (Sponsor‑Dedicated /Remote – US Based)

Are you a contracts expert who thrives on navigating complexity, building strong site partnerships, and driving timelines forward? Syneos Health is seeking a Senior Site Contracts Manager to support a sponsor‑dedicated program focused on high‑impact Pharma & Vaccine studies. If you’re energized by problem‑solving, negotiation, and leading projects across multiple therapeutic areas—especially oncology—we’d love to meet you.

About the Role:

As a Senior Site Contracts Manager , you’ll serve as a strategic expert responsible for developing, negotiating, and managing US site budgets and clinical trial agreements. You’ll collaborate closely with internal teams, external stakeholders, and major academic institutions to craft robust contracts that support operational excellence while minimizing risk.

This role is perfect for a communicator, leader, and negotiator who’s ready to hit the ground running and make an immediate impact.

Key Responsibilities:

Budgeting & Template Development

• Build US site budget templates and study‑specific budget language for Pharma & Vaccine clinical trials.

• Develop and refine templates to support consistency, compliance, and strategic study needs.

Contract Negotiation & Risk Management

• Lead direct negotiations with large academic institutions and other critical stakeholders.

• Draft and finalize clinical trial agreements that balance business objectives with legal and operational protections.

• Conduct due diligence checks—such as FMV assessments and site justification reviews—when initial offers are declined.

• Determine when requests require budget or language escalation and secure appropriate approvals.

Project Leadership & Delivery

• Prioritize and lead multiple contracting projects across several therapeutic areas (oncology experience strongly preferred).

• Proactively escalate risks, timeline impacts, or delays that could affect CTA execution.

Tools, Systems & Communication

• Demonstrate expert proficiency in Excel and clinical trial management systems.

• Communicate effectively in both written and verbal formats, incorporating feedback seamlessly.

• Maintain accurate and timely updates in departmental trackers and databases.

Compliance, Collaboration & Continuous Improvement

• Deepen and maintain knowledge of GCP, sponsor processes, SOPs, work instructions, and new technologies.

• Build strong working relationships with internal and external partners.

• Support and train additional team members as needed.

• Contribute to process improvement initiatives that simplify workflows and eliminate inefficiencies.

• Take on ad‑hoc tasks and diverse projects with a solutions‑oriented mindset.

Preferred Qualifications:

• Oncology therapeutic area experience

• Prior experience with pharma, CRO, or investigative sites

• Strong project management skills and comfort leading cross‑functional efforts

What You Bring (Minimum qualifications):

• 4+ years building budgets and contracts from templates

• Direct experience negotiating with large academic institutions

• Ability to juggle priorities, lead projects, and deliver results under tight timelines

• Strong understanding of clinical study protocols, timelines, and site‑related milestones (e.g., SIV)

• Bachelors degree

If you’re ready to elevate your contracting career in a critical sponsor‑dedicated role—and join a team driven by trust, transparency, and high performance—this is your opportunity!

At Syneos Health, we believe in providing an environment and culture in which Our People can thrive, develop and advance. We reward and recognize our people by providing valuable benefits and a quality-of-life balance. The benefits for this position may include a company car or car allowance, Health benefits to include Medical, Dental and Vision, Company match 401k, eligibility to participate in Employee Stock Purchase Plan, Eligibility to earn commissions/bonus based on company and individual performance, and flexible paid time off (PTO) and sick time. Because certain states and municipalities have regulated paid sick time requirements, eligibility for paid sick time may vary depending on where you work. Syneos complies with all applicable federal, state, and municipal paid sick time requirements.

Salary Range:

$79,800.00 - $139,600.00

The base salary range represents the anticipated low and high of the Syneos Health range for this position. Actual salary will vary based on various factors such as the candidate’s qualifications, skills, competencies, and proficiency for the role.

Get to know Syneos Health

Over the past 5 years, we have worked with 94% of all Novel FDA Approved Drugs, 95% of EMA Authorized Products and over 200 Studies across 73,000 Sites and 675,000+ Trial patients.

No matter what your role is, you’ll take the initiative and challenge the status quo with us in a highly competitive and ever-changing environment. Learn more about Syneos Health.

Additional Information

Tasks, duties, and responsibilities as listed in this job description are not exhaustive. The Company, at its sole discretion and with no prior notice, may assign other tasks, duties, and job responsibilities. Equivalent experience, skills, and/or education will also be considered so qualifications of incumbents may differ from those listed in the Job Description. The Company, at its sole discretion, will determine what constitutes as equivalent to the qualifications described above. Further, nothing contained herein should be construed to create an employment contract. Occasionally, required skills/experiences for jobs are expressed in brief terms. Any language contained herein is intended to fully comply with all obligations imposed by the legislation of each country in which it operates, including the implementation of the EU Equality Directive, in relation to the recruitment and employment of its employees. The Company is committed to compliance with the Americans with Disabilities Act, including the provision of reasonable accommodations, when appropriate, to assist employees or applicants to perform the essential functions of the job.