Senior Research Associate, Proteomics

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS‑addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC‑6236), a RAS(ON) multi‑selective inhibitor; elironrasib (RMC‑6291), a RAS(ON) G12C‑selective inhibitor; zoldonrasib (RMC‑9805), a RAS(ON) G12D‑selective inhibitor; and RMC‑5127, a RAS(ON) G12V‑selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway. The Opportunity Revolution Medicines is seeking a motivated and detail‑oriented individual to support and advance mass spectrometry‑based proteomics workflows. This role is well‑suited for a scientist with prior industry experience who is excited to apply and expand their expertise in proteomics within a drug discovery environment. This position will involve executing and optimizing laboratory workflows, maintaining high‑quality data standards, and contributing to the development of new capabilities within the team. The ideal candidate will demonstrate strong technical proficiency, attention to detail, and the ability to work both independently and collaboratively. In this role, success will come from consistently delivering high‑quality, reproducible data, maintaining well‑documented experiments, and proactively identifying opportunities to improve workflows and efficiency. As a key member of the Proteomics group within our dynamic Chemical Biology team, you will: Perform sample preparation for bottom‑up proteomics workflows with high attention to detail and reproducibility. Execute, troubleshoot and optimize automated proteomics workflows. Support routine instrument operation, maintenance and quality control of LC and MS/MS instrumentation. Accurately document experiments and results in lab notebook and other electronic records. Generate reliable, high‑quality data to support project decisions. Work with project scientists to analyze and interpret data and contribute to experimental design. Required Skills, Experience and Education Bachelor’s degree in biology, biochemistry, biotechnology, or a related field with 4+ years of relevant industry experience, or Master’s degree with 2+ years of relevant industry experience. Hands‑on experience with proteomics workflows and/or mass spectrometry (LC‑MS/MS). Experience with common biochemical or cell biology techniques (e.g., SDS‑PAGE, Western blot, protein quantification, or cell culture). Strong attention to detail, organization, and record‑keeping skills. Demonstrated ability to execute experiments independently and manage routine workflows with consistency and accuracy. Ability to analyze data and contribute to experimental design and problem‑solving. Strong communication skills and ability to work collaboratively in a team environment. Preferred Skills Experience with Thermo Fisher mass spectrometry platforms. Experience with automated liquid handling systems. Experience with proteomics sample preparation and workflow optimization. Base Pay Salary Range: $106,000 - $126,000 USD Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status. #J-18808-Ljbffr Revolution Medicines