Medicinal Chemistry Senior Principal Research Scientist

Job Description

Vertex is seeking a Senior Principal Research Scientist Medicinal Chemistry to provide scientific leadership in the design and optimization of small-molecule therapeutics across discovery programs. Leading from the lab this role will play a critical part in advancing high-quality drug candidates from early discovery through candidate selection while partnering across multidisciplinary teams to solve complex scientific challenges.

The ideal candidate is an accomplished medicinal chemist with deep expertise in small-molecule drug discovery a strong record of scientific innovation and demonstrated success in a fast-paced and matrixed research environment. This is an on-site role with approximately 75% of time being spent in the lab.

Key Responsibilities

• Lead medicinal chemistry strategy for small-molecule discovery programs aligned with portfolio and project objectives.
• Design prioritize and guide synthesis of novel compounds to optimize potency selectivity pharmacokinetics and developability.
• Interpret and integrate SAR structural biology DMPK pharmacology and safety data to drive compound design and progression.
• Partner closely with biology DMPK toxicology and pharmaceutical sciences to advance program goals.
• Provide technical and strategic leadership to internal and external chemistry resources.
• Provide scientific leadership mentorship and development support to chemistry team members.
• Communicate program strategy data risks and recommendations to senior leadership and governance teams.
• Support intellectual property strategy in partnership with internal stakeholders.

Knowledge and Skills:

• Medicinal chemistry
• Organic synthesis
• Small-molecule drug discovery
• Lead optimization
• SAR analysis
• Compound design
• Candidate selection
• DMPK/ADME collaboration
• Drug property optimization
• Patent support

Education and Experience:

• Ph.D. in Chemistry or related scientific discipline with 6 years of relevant postdoctoral industry experience; Masters degree with 9 years of relevant industry experience; or Bachelors degree with 11 years of relevant industry experience.
• Significant experience in medicinal chemistry and small-molecule drug discovery.
• Demonstrated success advancing discovery programs through candidate selection.
• Experience leading cross-functional and multidisciplinary teams including in matrixed settings.
• Strong communication strategic thinking decision-making prioritization and problem-solving skills.

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At Vertex we embrace continuous learning and encourage employees to stay informed on advances in AI technology automation and industry trends. We seek talent who bring an external perspective demonstrate curiosity and sound judgment and thoughtfully adopt new capabilities that improve decision-making drive innovation increase efficiency and help deliver better outcomes for patients.

Pay Range:

Disclosure Statement:

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors including skills competencies experience and other job-related factors permitted by law.

At Vertex our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career financial family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter) educational assistance programs including student loan repayment a generous commuting subsidy matching charitable donations 401(k) and so much more.

Flex Designation:

Flex Eligibility Status:

In this On-Site designated role you will work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertexs Policy on Flex @ Vertex Program and may be changed at any time.

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Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a persons race color sex gender identity or expression age religion national origin ancestry ethnicity disability veteran status genetic information sexual orientation marital status or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager or contact Talent Acquisition at

Required Experience:

Staff IC