Senior Director, Global Tuberculosis

Overview

The Clinton Health Access Initiative, Inc. (CHAI) is a global health organization committed to our mission of saving lives and reducing the burden of disease in low-and middle-income countries. We work at the invitation of governments to support them and the private sector to create and sustain high-quality health systems.

CHAI was founded in 2002 in response to the HIV/AIDS epidemic, with the goal of dramatically reducing the price of life-saving drugs and increasing access to these medicines in the countries with the highest burden of the disease. Over the following two decades, CHAI has expanded its focus. Today, along with HIV, we work with our partners to prevent and treat infectious diseases such as COVID-19, malaria, tuberculosis, and hepatitis. Our work has also expanded into cancer, diabetes, hypertension, and other non-communicable diseases, and we work to accelerate the rollout of lifesaving vaccines, reduce maternal and child mortality, combat chronic malnutrition, and increase access to assistive technology. We are investing in horizontal approaches to strengthen health systems through programs in human resources for health, digital health, and health financing. With each new and innovative program, our strategy is grounded in maximizing sustainable impact at scale, ensuring that governments lead the solutions, that programs are designed to scale nationally, and learnings are shared globally.

At CHAI, our people are our greatest asset, and none of this work would be possible without their talent, time, dedication, and passion for our mission and values. We are a highly diverse team of enthusiastic individuals across 40 countries with a broad range of skill sets and life experiences. CHAI is deeply grounded in the countries we work in, with the majority of our staff based in program countries. Learn more about our exciting work:

CHAI is an Equal Opportunity Employer, and is committed to providing an environment of fairness, and mutual respect where all applicants have access to equal employment opportunities. CHAI values diversity and inclusion, and recognizes that our mission is best advanced by the leadership and contributions of people with diverse experience, backgrounds, and culture.

CHAI’s Global TB Program Overview

Tuberculosis is the world’s deadliest infectious disease. Beyond 10 million people fall ill each year, and 1.2 million die, with a disproportionate burden in sub-Saharan Africa and South and Southeast Asia. Roughly 40% of TB cases remain undiagnosed, fuelling ongoing transmission in communities. Children under five, people living with HIV, and those in underserved or displaced populations face the greatest risk.

CHAI partners with governments, multilateral organizations, and suppliers to close critical gaps across the TB care cascade. Our work spans three interconnected domains:

• Screening and diagnosis: accelerating the adoption of digital chest X-ray with AI, near-point-of-care molecular diagnostics, tongue swabs, and sample pooling strategies that bring accurate, rapid testing closer to patients.
• Treatment and prevention: expanding access to shorter, more effective regimens for both active and latent TB, with particular focus on community-based delivery of TB preventive therapy to children under five and other high-risk household contacts.
• Market shaping: negotiating price reductions, supporting generic product development, and ensuring sustainable supply of quality-assured TB commodities, from rifapentine-based preventive regimens to next-generation diagnostic platforms.

The program currently operates across 13 countries in Africa and Asia. CHAI’s Global TB Team provides strategic direction, technical leadership, and coordination across these country programs, while managing relationships with key funders and partners including the Global Fund, Gates Foundation, Unitaid, FCDO, GiveWell, Stop TB Partnership, and national TB programs.

Position Overview

New diagnostic tools, shorter treatment regimens, and growing political will are converging to create a real opportunity to reduce the toll of TB. At the same time, uncertain funding landscapes, fragmented health systems, and the sheer scale of the undiagnosed burden demand a leader who can operate with both strategic ambition and operational discipline.

We are looking for a Senior Director who will serve as CHAI's most senior voice on TB, both internally and externally. This person will set a clear programmatic vision, articulate it compellingly, and bring a wide range of audiences along country teams translating strategy into action, government leaders deciding how to allocate scarce resources, and funders weighing where to invest. That funder base includes long-standing partners such as the Gates Foundation and Unitaid, whose support remains central to the program, as well as a growing set of evidence-driven philanthropists who assess TB investments on cost-effectiveness and counterfactual impact. The Senior Director will need to sustain and deepen the first set of relationships while building the second, making the case for TB with rigour and in the terms each funder uses.

The TB landscape involves a rich ecosystem of multilateral organizations, bilateral donors, research institutions, civil society, and national programs, each with distinct mandates, priorities, and ways of working. Success in this role requires someone who can build trust and find common ground across that ecosystem, forging alignment where interests converge and navigating constructively where they diverge.

Reporting to the Vice President, HIV, Hepatitis and TB, the Senior Director will be responsible for shaping a portfolio that spans community-based prevention pilots, diagnostic technology introduction, market shaping interventions, and operational research across multiple countries. The Senior Director will lead a team that includes two Directors who serve as the program's scientific and technical leads, bringing deep expertise in TB diagnostics, treatment, prevention, and market shaping. The Senior Director's role is strategic ownership of the overall program direction, impact model, and funder relationships, working in close partnership with these Directors to ensure technical excellence and programmatic coherence across the portfolio.

The ideal candidate brings a rigorous, quantitative approach to deciding where resources do the most good and a track record of delivering sustainable public health impact in low- and middle-income countries. They will set a compelling strategic direction that galvanizes teams and partners and translates into measurable, large-scale impact in the countries where TB takes its greatest toll.

Responsibilities

Strategy and Program Leadership

• Define and communicate a bold strategic direction for CHAI's global TB portfolio, translating organizational priorities, donor expectations, and the evolving needs of high-burden countries into a coherent vision that the team, partners, and governments can rally behind.
• Scan the horizon for shifts in TB financing, epidemiology, policy, and the diagnostic and therapeutic pipeline; position CHAI to respond proactively and shape the conversation.
• Make disciplined strategic choices about where CHAI should focus, including decisions to scale, pivot, or wind down workstreams based on evidence of impact per dollar, counterfactual value, and changing conditions.
• Develop multi-year programmatic plans, budgets, and performance management systems that drive accountability and continuous improvement across the portfolio.
• Champion the translation of evidence and operational learning into scalable, government-led program models.
• Orient the program at every stage toward government ownership, from design through financing and scale-up, so that impact endures beyond CHAI's engagement.

Resource Mobilization and Funder Engagement

• Lead development and execution of CHAI's TB resource mobilization strategy, sustaining and growing support from long-standing institutional donors while building a significant new base of support from evidence-driven philanthropy, and building resilience against shifts in the global aid landscape.
• Manage major donor relationships and program finances, including with the Global Fund, Gates Foundation, Unitaid, FCDO, and GiveWell, ensuring high-quality reporting, proactive risk management, and disciplined deployment of resources.
• Build relationships with funders who prioritize cost-effectiveness, including foundations, individual philanthropists, and pooled funds associated with the effective giving community.
• Make the case for TB investment in the terms these funders use: cost per death or disability-adjusted life year (DALY) averted, counterfactual impact, room for more funding, and the quality of the underlying evidence.
• Engage directly with funders' research and grant making staff, responding to detailed questions about assumptions, uncertainty, and track record, and using that scrutiny to strengthen the program.
• Identify and pursue non-traditional funding opportunities, positioning CHAI's TB work within broader global health and development agendas, including the growing interest in AI-enabled health solutions.

Analytical and Technical Leadership

• Set the intellectual agenda for CHAI's TB work: define the questions the organization should be asking, identify where conventional approaches are falling short, and push the team to develop stronger answers.
• Own the TB program's impact model: the cost-effectiveness estimates, assumptions, and uncertainty behind CHAI's investment case. Revise it as evidence changes and defend it with funders, partners, and governments.
• Ensure country and regional teams receive strong technical guidance on complex programmatic, policy, and scientific questions spanning diagnostics, treatment, prevention, and service delivery, working closely with the program's technical Directors.
• Drive CHAI's TB learning and research agenda, including operational research, impact evaluations, cost-effectiveness analyses, and data-driven refinements to program design, ensuring that findings are translated into action.
• Ensure CHAI stays ahead of the frontier of TB science and innovation, so it can move quickly as new screening, diagnostic, and treatment tools emerge.

External Representation and Ecosystem Influence

• Represent CHAI at the highest levels of the global TB community, from ministerial meetings to donor convenings to technical forums, and in philanthropic settings where TB competes with other causes for funding.
• Actively shape how the global community prioritizes, funds, and organizes the TB response, bringing evidence and operational insight to bear on policy and investment decisions.
• Strengthen CHAI's positioning as a trusted partner and thought leader in the TB ecosystem, known for evidence-informed approaches and a commitment to practical, scalable solutions.
• Build and sustain trusted relationships across a diverse ecosystem of multilateral organizations (WHO, the Global Fund, Stop TB Partnership), bilateral donors, academic institutions, suppliers, implementing partners, and civil society, understanding each partner's priorities and finding productive ways to collaborate toward shared objectives.
• Navigate a multi-stakeholder landscape with diplomacy and strategic clarity, identifying opportunities for collective action while ensuring CHAI's distinctive contributions are well understood and valued.
• Contribute to shaping the global policy environment for TB, including regulatory pathways, normative guidance, and investment frameworks.

Team Leadership and People Development

• Lead, develop, and grow a diverse, high-performing team, strengthening the team's capabilities over time to keep pace with the program's evolving ambitions.
• Provide direct management and mentorship to senior team members, including the program's two technical Directors and other managers of people, investing in their professional development and enabling them to lead their respective portfolios with confidence and autonomy.
• Foster a team culture grounded in intellectual rigour, collaboration, accountability, and continuous learning.

Organizational Leadership and Cross-Cutting Collaboration

• Own the TB program's results. Be accountable not only for how the work is managed but for what it achieves: reductions in undiagnosed TB, expanded preventive treatment coverage, sustainable improvements in how countries detect, treat, and prevent the disease, and a clear account of what each dollar invested delivers.
• Work in close partnership with CHAI country directors and country-based staff, recognizing that the strongest global strategies are built on the insights, relationships, and operational realities that country teams bring.
• Collaborate closely with leaders across CHAI's HIV, Diagnostics, Markets, Health Systems, and AI programs to identify synergies, share learning, and pursue integrated approaches where they strengthen impact.
• Contribute to organization-wide initiatives that strengthen CHAI's culture, effectiveness, and ability to adapt in a rapidly changing global health landscape.

Qualifications

• 10+ years of progressive experience in global health, development, philanthropy, or a related field, with increasing levels of responsibility and leadership.
• Strong grounding in economics, cost-effectiveness analysis, or quantitative approaches to resource allocation, with the ability to build, interrogate, and explain impact models.
• Fluency in how evidence-driven funders evaluate opportunities and make decisions, with the credibility to engage them as a peer.
• Demonstrated success leading global or multi-country programs, or advising governments or directing funding for them, with a clear track record of contributing to measurable public health impact in low- and middle-income countries.
• Outstanding communicator who can distil complex technical and strategic issues into clear, persuasive narratives for varied audiences, and who uses communication deliberately to build consensus, inspire action, and sustain momentum behind a shared vision.
• Strong resource mobilization experience, including leading successful proposal development and donor engagement for large, multi-year grants.
• Excellent project and people management skills, including managing senior technical staff and designing and managing cross-functional teams spanning multiple geographies and time zones.
• Demonstrated high bar for quality, analytical rigour, and attention to detail in programmatic outputs and strategic deliverables.
• Track record of building and managing relationships with senior government officials, multilateral organizations, and major institutional donors, with demonstrated ability to align diverse stakeholders around a common agenda and maintain productive partnerships even when organizational interests do not fully overlap.
• Entrepreneurial mindset, with the ability to identify and pursue new opportunities, work independently, and drive initiatives forward in fast-paced, limited-structure environments.
• Ability and willingness to travel internationally 25 to 30 percent of the time.

Preferred

• Experience working at, with, or for evidence-focused or effective giving-aligned funders, or in roles where cost-effectiveness analysis drove resource allocation decisions.
• Knowledge of tuberculosis, including TB epidemiology, diagnostics, therapeutics, and the global TB policy and financing architecture.
• Prior experience working with or within national TB programs, the Stop TB Partnership, the Global Fund, Gates, or Unitaid.
• Experience in market shaping, health commodity procurement, or access-to-medicines initiatives in a global health context.
• Experience living and working in sub-Saharan Africa, South or Southeast Asia, or other high-TB-burden regions.
• Advanced degree in economics, public policy, public health, management, science, or other relevant fields.

Why This Role

TB kills more people than any other infectious disease, yet it is both preventable and curable, and the tools to find, treat, and prevent it are inexpensive relative to the deaths they avert. Breakthroughs in diagnostics, shorter and more tolerable treatment regimens, and community-based delivery models have created real momentum. CHAI is at the centre of that momentum, with the relationships, operational reach, and market shaping expertise to turn promising innovations into population-level impact. The Senior Director will have the platform and the organizational backing to lead one of the most consequential programs in global health today.

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