Director, US Medical Affairs Strategic Operations

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.The Opportunity:The Director of US Medical Affairs Operations will be instrumental in enabling medical impact through operational leadership, strategic planning, process and systems enablement across the full product lifecycle and portfolio. Reporting to the VP, Medical Affairs, this highly visible role drives planning, integration, execution, and governance of medical affairs activities across the US Medical Affairs portfolio. As a core member of the USMA Leadership Team, this role ensures that strategy is translated into coordinated, high-impact execution across US cross-functional stakeholders. This role will collaborate across internal teams and external partners to deliver compliant, efficient, and scalable solutions that support medical strategy, launch readiness, and scientific exchange in the US Region. Key responsibilities include:Strategic Operations Leadership & Execution ManagementTranslate Medical Affairs strategy into aligned goals and cross-functional plans spanning scientific engagement, communications, evidence generation, and launch readiness; enable alignment between US and Global strategies and drive clarity on priorities and execution.Partner with the Head of US Medical Affairs, Global Medical Affairs, Global Commercialization, US Commercial and Market Access, Regulatory and Clinical Development stakeholders to ensure strategic alignment and coordinated execution.Led complex, cross-functional medical workstreams spanning launch readiness, scientific communications, congress strategy, HEOR/IEP coordination, and external engagement strategy for new product launches, indication expansions, and lifecycle management.Establish a clear operating rhythm to facilitate strategic planning, budgeting, and business reviews and align with enterprise and global strategic planning efforts.Serve as trusted advisor to VP and US Medical Affairs Leadership by synthesizing complex clinical, scientific and market insights into actional recommendations to enable timely decision making, prioritization, planning, and resourcing of US Medical Affairs priorities.Medical Governance & Compliance and Organizational EnablementEvolve US Medical Affairs governance frameworks, including Medical Review Committees (MRC), and US Medical Asset Teams (US MATs) & assess how to effectively coordinate acros various enterprise forums (as needed) as the portfolio grows.Partner with Regulatory and Compliance to ensure compliance with US regulatory standards (FDA, GVP, PhRMA Code), internal policies, and legal requirements.Establish and maintain SOPs, training, and internal education to build operational excellence and capabilities across Medical Affairs.Serve as a Medical Affairs representative for inspection readiness and audit support, providing training, documentation, and cross-functional coordination.US Region representation & leadership across Medical Operations ExcellenceBuild strong relationships with Global Medical Affairs Operational Excellence and partner with US Medical Field Operations Manager to synergize efforts and evolve grant and funding, congress, ad board and publications planning and execution to meet US Region needs.Systems, Tools, and Digital EnablementChampion continuous innovation in US Medical Affairs operations, advance new ways of working including AI-enabled insights and data-drive planning to drive simplification, scalability and improved decision Medical Affairs processes.Collaborate on implementation and governance of digital platforms for insights management, medical planning, and content review.Required Skills, Experience and Education:Bachelor’s (BS) degree required; advanced degree (MS, MBA, PharmD, PhD) or PMP certification strongly preferred.15+ years of experience in biotechnology or pharmaceutical industry (with BS), 13+ years (with MS) or 11+ years (with PharmD/PhD), including 8+ years in Medical Affairs or biotechnology project or program management roles.Experience working in the Medical Affairs function, including scientific communications, external engagement, medical congresses, medical compliance, and data dissemination.Experience creating strong partnerships across Medical, Commercial, Regulatory and G&A functions.Proven track record of leading large, cross-functional initiatives with significant visibility and complexity and building for launch readiness.Excellent communication, interpersonal, and presentation skills to engage internal and external stakeholders effectively.Strong financial acumen, strategic thinking, and ability to manage ambiguity in a fast-paced environment.Strong project management skills to oversee multiple priorities, timelines, and stakeholders effectively.Preferred Skills:Oncology and/or precision medicine experience strongly preferred.Previous leadership of Medical Governance frameworks or Medical Review Committees.Experience scaling Medical Affairs operations during rapid growth or product launch phases.Familiarity with digital tools and innovative solutions for medical insights and communications. #LI-Hybrid #LI-YG1The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact View email address on click.appcast.io Pay Salary Range$211,000—$264,000 USDWe are aware of recent recruitment scams in which individuals or organizations falsely represent themselves as being affiliated with Revolution Medicines. These scams may appear as false job advertisements or unsolicited contacts through communication or chat platforms, email, phone, or text message.Please note that Revolution Medicines does not extend unsolicited employment offers and will never ask candidates to provide financial information, purchase equipment, or pay fees as part of the hiring process. All legitimate communication from Revolution Medicines will come from an official @revmed.com email address.If you believe you’ve been contacted by someone impersonating a Revolution Medicines recruiter, please report it to View email address on click.appcast.io so we can share these impersonations with our IT team for tracking and awareness.