Postdoctoral Research Associate - Chemical Biology & Therapuetics

Postdoctoral Research Associate - Chemical Biology & Therapuetics

Location: Memphis, TN

Job Description

A postdoc position is available in the lab of Taosheng Chen. The Chen Lab ( is seeking a Postdoctoral Research Associate to work in a multidisciplinary team to study the regulation of PXR and CAR, or CYP3A4 and CYP3A5, by characterizing novel chemical probes (small molecule inhibitors or degraders) in biochemical/biophysical, cellular, and animal models.

Drug toxicity and resistance are leading causes of therapeutic failures. The Chen Lab studies the chemical regulation of nuclear xenobiotic receptors and the mechanism of selective modulation of highly homologous drug‑metabolizing enzymes. Our approach is hypothesis‑driven and technology‑enabled, focusing on developing chemical probes, investigating biological mechanisms, and evaluating in‑vivo efficacy. We use the promiscuous pregnane X receptor (PXR) and constitutive androstane receptor (CAR) as models to understand nuclear receptor‑regulated transcription networks, enzyme‑drug interactions, and design therapeutic approaches to overcome drug resistance and toxicity.

Postdoctoral fellows will collaborate across biologists, medicinal chemists, and structural biologists to characterize novel probes, organize and prepare manuscripts, and develop grant proposals. Fellows are trained in manuscript and grant writing and are encouraged to prepare and submit grant proposals.

St. Jude is an Equal Opportunity Employer.