SAP Principal Enterprise Architect, S/4HANA & Digital Platforms

Location San Diego HQ – Hybrid. Must currently reside in the San Diego metropolitan area or commute independently. Role requires onsite presence for all workshops. Position Summary The SAP S/4HANA & Digital Platforms Enterprise Architect provides strategic and hands‑on architectural leadership for enterprise‑wide digital transformation initiatives, with SAP S/4HANA as the digital core, integrated with best‑of‑breed platforms such as Salesforce, MES, LIMS, Vertex, SAP VIM, and other ERP and non‑ERP systems. This role defines future‑state enterprise architecture, governs solution design, and ensures alignment between business strategy, process design, data, integration, security, and technology platforms. Success requires technical architecture expertise, stakeholder partnership, and influence‑based leadership across business and IT. Key Responsibilities Enterprise Architecture & Strategy Leadership Own and evolve enterprise architecture vision, principles, standards, and roadmaps across business, application, data, and technology domains. Develop future‑state architecture and transition roadmaps aligned with business growth objectives. Serve as a trusted advisor to business and IT leadership on architectural trade‑offs, sequencing, and investment decisions. Lead and participate in architecture governance forums (Design Authority, Architecture Review Boards). SAP S/4HANA as the Digital Core Define and govern SAP S/4HANA target‑state architecture as the enterprise ERP backbone. Enforce clean‑core principles, extensibility strategies (in‑app vs side‑by‑side), and SAP best practices. Provide architectural guidance across SAP domains including Finance, Sales, Supply Chain, Manufacturing, Quality, EAM, and EHS. Build and maintain the ERP strategy and roadmap, including ECC‑to‑S/4 or multi‑ERP coexistence scenarios. Boundary Systems & Ecosystem Architecture Architectural oversight and integration strategy for enterprise platforms such as Salesforce (CRM, Service, CPQ, Order‑to‑Cash integrations), Manufacturing Execution Systems (MES), Laboratory Information Management Systems (LIMS), Vertex, SAP VIM. Oversee legacy, regional, or niche ERPs during coexistence or transition. Ensure clear system‑of‑record ownership, scalable integration patterns, data consistency, reconciliation, and error handling. Integration, Data & Reporting Architecture Define enterprise integration strategy (API‑led, event‑driven, middleware‑based). Govern integration platforms such as SAP BTP, CPI, MuleSoft or equivalent. Head ERP‑related integration rationalization and optimization. Define master data ownership, governance models, and reporting strategies (real‑time vs operational). Align with analytics, AI/ML, and data platform needs. Solution Delivery & Transformation Enablement Partner with PMO, delivery leads, and system integrators across Design, Build, Test, and Deploy. Review and approve solution artifacts (HLDs, FSDs, TSDs, integration and security designs). Establish and promote business capability models linking strategy, processes, systems, and data. Identify architectural risks early and recommend mitigation strategies. Ensure adherence to quality standards across solution design and delivery. Security, Compliance & Non‑Functional Architecture Ensure solutions meet security, SOX, GxP, data privacy, and regulatory requirements. Define and govern non‑functional requirements: performance, scalability, availability, disaster recovery. Guide system retirement, data retention, and audit readiness strategies. Stakeholder, Vendor & Partner Leadership Build strong, trust‑based relationships with business, functional, infrastructure, procurement, and IT teams. Provide architectural direction to system integrators and SaaS vendors. Evaluate and challenge vendor proposals and RFP responses to align with enterprise standards. Research and assess emerging technologies for fit within the enterprise application portfolio. Education & Experience 18+ years of experience in enterprise IT architecture and solution delivery. Bachelor’s degree or equivalent experience. Proven experience leading large‑scale digital and ERP transformation programs. Deep hands‑on and architectural experience with SAP S/4HANA in enterprise environments. Core Technical & Architecture Expertise SAP S/4HANA architecture, extensibility, and integration. Enterprise integration patterns (API, middleware, event‑driven). Salesforce (SFDC), MES, LIMS platforms. Finance solutions (Vertex, SAP VIM). Master data management and reporting systems. Legacy and co‑existing ERP environments. Cloud platforms (SAP BTP, Azure, AWS, or GCP). Leadership & Business Architecture Skills Strong expertise in TOGAF, Zachman, or equivalent EA frameworks. Hands‑on experience with business capability modeling. Ability to translate business strategy into executable architecture. Excellent communication, influence, and consensus‑building skills. Strong analytical and problem‑solving capabilities. Preferred Qualifications Experience in Life Sciences, Manufacturing, or regulated industries. SAP certifications (S/4HANA, Architecture, BTP). Experience with digital manufacturing, advanced analytics, or AI‑enabled platforms. Experience with ERP modernization or multi‑year transformation programs. Advanced degree in Computer Science, Engineering, or related field. Benefits Innovative benefits include access to genomics sequencing, family planning, health/dental/vision, retirement benefits, and paid time off. Employees enjoy a culture that promotes belonging and inclusivity. Compensation Estimated base salary: $170,600 – $255,800 per annum, commensurate with experience and location. Variable cash programs and equity may also apply. EEO Statement Illumina is an equal opportunity employer. We consider applicants regardless of sex, race, creed, color, gender, religion, marital status, domestic partner status, age, national origin, disability, medical condition, sexual orientation, pregnancy, military or veteran status, citizenship, and genetic information. Employment decisions are based solely on qualifications and are in accordance with applicable laws. #J-18808-Ljbffr Illumina