Computational Protein Engineer
Gables Search Group
We are recruiting for a research-driven biotechnology organization seeking a Computational Protein Engineer to lead hands-on antibody and protein engineering programs in Rockville, Maryland. This position combines wet-lab experimentation with computational design tools to accelerate discovery, guide design decisions, and improve experimental outcomes.
The organization offers scientists meaningful independence, access to accomplished colleagues, and the opportunity to pursue creative research with long-term impact.
Key Responsibilities
Lead antibody and protein engineering programs, including affinity maturation, multispecific antibodies, and novel binder development
Develop protein expression, purification, and analytical characterization workflows across multiple formats
Design binding, biochemical, and functional assays to evaluate engineered candidates
Apply tools such as AlphaFold, Rosetta, and ProteinMPNN to prioritize designs and guide laboratory strategies
Partner with structural biologists and computational scientists to translate modeling insights into experimental programs
Provide technical leadership across complex, multidisciplinary research initiatives
Communicate findings, recommendations, and project progress to scientific stakeholders
Qualifications
PhD in biochemistry, molecular biology, protein science, or a related discipline
Industry experience conducting hands-on antibody or protein engineering research
Strong expertise in protein expression, purification, characterization, and assay development
Experience with bispecific antibodies, nanobodies, multispecific proteins, or similar modalities
Familiarity with computational protein design and structure-prediction platforms
Scientific contributions demonstrated through publications, patents, or successful development programs
Ability to lead technical projects and collaborate across scientific disciplines
Apply today to explore a position where computational design and experimental protein engineering come together to advance meaningful scientific discovery.
- Gables Search Group is assisting a research-driven biotechnology organization in Rockville, MD to hire a Computational Protein Engineer who will lead hands-on antibody and protein engineering programs, integrating wet-lab experimentation with computational design to accelerate...Suggested
$67.9k - $101k
...maintenance schedules for specialized lab equipment. Purify protein solutions via FPLC to prepare conjugation or coating solutions... ...requirements. Experience And Qualifications Bachelor’s degree in Engineering, Biotechnology, Chemistry, Biology or related field. One year...SuggestedTemporary workFlexible hours$116.6k - $177.8k
...position will play a critical role in supporting high-impact research initiatives. This individual will lead a multidisciplinary team of engineers and scientists in the research and development of automated cell analysis consumables and analyzers. The role involves close...SuggestedFull timeTemporary workWork at officeFlexible hours- ...planet. From oncology and rare disorders to COVID-19 or alternative proteins, our design and construction projects are pioneering solutions... ...the RoleThe Lead Automation, Instrumentation, & Controls Engineer is responsible for overseeing the discipline at a project level...Suggested
$158k - $183k
...or nuclear facility.Job Profile Tasks/ResponsibilitiesPerform design, analysis, and evaluation in assigned projects using sound engineering principles and adhering to business standards, practices, procedures, and product / program requirements.Lead the execution of the...SuggestedFull timeFor contractorsWork at office$116.6k - $177.8k
...related to the research and development of manufacturing methods for clinical consumables. This position will work with a team of engineers and scientists to design and evaluate novel and high throughput manufacturing techniques for next generation diagnostic consumables...Full timeTemporary workWork at officeFlexible hours- ...at .Job DescriptionX-energy is seeking a Senior Manufacturing Engineer responsible for translating complex nuclear component designs... ...meet technical specifications and design requirements.Perform computations utilizing hand calculations and analytical tools for structural...Full timeInternshipWork at office
- The RoleWe are looking for a pragmatic builder-architect — a senior engineer who ships fast without leaving a mess, and makes architectural choices that hold up as the product scales. This is a hands-on technical leadership role: roughly 40% writing code and prototyping...Hourly payFull timeTemporary workWork at officeFlexible hours3 days per week
$96.2k - $144.3k
AstraZeneca is seeking an experienced senior process engineer for our cell therapy Global Manufacturing Science and Technology (MS&T) team. This position is responsible for supporting the technical oversight of robust, compliant, and cost-effective end-to-end cell therapy...Full timeTemporary work- Intellian Technologies in Rockville, MD seeks an Antenna RF Test Engineer to test and characterize phased array antenna and RF modules for satellite communication user terminals. You will draft test plans and set up RF measurement systems to verify design requirements....
- GDIT is seeking a Senior Test Engineer in Gaithersburg, MD to join our FDA support team. Hybrid onsite three days a week, you will develop and maintain functional test cases, automate scripts, and work within an Agile framework to ensure timely delivery of quality software...3 days per week
- Summary NIST is seeking an Applied Research Engineer to perform complex calibration and experimental tasks. The role involves ensuring... ..., develop, and operate experimental flow systems, utilizing Computational Fluid Dynamics (CFD) and other analytical tools to support...InternshipWork at office
- ...Strategic Group (SSG) is seeking a talented Senior Software Test Engineer Location: Remote Department: Veterans Affairs (VA)... ...Services (AWS) and Azure) Formal Education Bachelor’s Degree in Computer Science, Information Technology, Engineering, or a related...Full timeWork experience placementRemote work
Ssg
Potomac, MD1 day ago - The National Institute of Standards and Technology (NIST) seeks an Applied Research Engineer to perform complex calibration and experimental tasks, ensuring traceability of measurements and adherence to metrology standards. The role focuses on developing systems for measuring...
$100k - $125k
...oversees the implementation of rigorous, repeatable Fire Protection Engineering processes, ensures technical integration, monitors risks, and... ...specifications and requirements.Supervise performance of computations utilizing hand calculations and analytical tools for...Full timeContract workWork at officeRemote work$107.9k - $195.05k
...go hand in hand? Leidos is seeking an experienced Senior Test Engineer to join the Chinook Program supporting an Intelligence Community... ...:US citizenship is required per contract. Bachelor's degree in Computer Science, Engineering, Information Technology or related field and...Full timeContract work$106.4k - $149k
...process. If anyone claiming to represent X-energy directs you in a manner otherwise, please contact us at .Job DescriptionCombine your engineering knowledge and business insights, to vet engineering services, equipment designers and fabricators to help develop a supplier...Full timeContract workWork at office- Brief Description The Design Engineer IV (Staff) works on high profile design projects that require new silicon created from either original... ...minimum Bachelor of Science degree in Electrical Engineering, Computer Science, or Computer Engineering required (BSEE, BSCS, or BSCE)...Full timeFlexible hours
$158k - $183k
...nuclear facility. Job Profile Tasks/Responsibilities Perform design, analysis, and evaluation in assigned projects using sound engineering principles and adhering to business standards, practices, procedures, and product / program requirements. Lead the execution of...Full timeFor contractorsWork at officeRemote workMonday to Friday- AMT Engineering is looking for a Civil Engineer based in Rockville, Maryland to join their team. The role involves supporting diverse projects with engineering reports, design tasks, and collaboration with various stakeholders. Candidates should possess a BS in Civil Engineering...
$95k - $120k
Overview M&J Engineering, D.P.C. (M&J) is a quality provider of multi-discipline consulting services with over 300 employees. Since its inception in 2004, M&J has grown into a diversified provider of engineering, construction management, construction inspection, technology...Full timeContract workFor contractorsWork at officeLocal area$101.4k - $154.7k
...duties may vary depending upon department requirementsEXPERIENCE AND QUALIFICATIONS.Bachelor’s degree or higher in Computer Science, Software Engineering, Electrical Engineering or other related science or engineering discipline is required.3-5 years working experience...Full timeTemporary workWork experience placementWork at officeFlexible hours- Rockville, MarylandHybridDirect Hire$130k - $165kSenior Engineer, Software Automation, based in Rockville, VAA growing life sciences and... ...PLCs, Ladder Logic, or Structured TextBachelor's degree in Computer Science, Software Engineering, Electrical Engineering, or a related...Full time
- Company DescriptionComtech is a woman-owned small business founded in 1998 and headquartered in Reston, VA. We offer IT solutions across the disciplines of program/project management, applications development, infrastructure, Cyber security, and enterprise content/data ...Flexible hours
$21 - $33 per hour
...Domestic and international shipping experience.Prior experience in a Life Science or Biotechnology role.Working knowledge of basic computer systems (MS Word, Excel, Outlook) and databases such as Oracle ERP or LIMS.Excellent oral and written communication skills....Immediate startEMD Group
Rockville, MD1 day ago- A reputable IT solutions provider in Gaithersburg is seeking a Network Engineer for a contract to hire position. The role involves designing and supporting distributed networks, configuring routers and switches, and ensuring network security. Ideal candidates should have...Contract work
$116.6k - $177.8k
...other staff members on automation software development processes.Perform any other engineering function as assigned.EXPERIENCE AND QUALIFICATIONS:Bachelor’s degree or higher in Computer Science, Software Engineering, Electrical Engineering or other related science or engineering...Full timeTemporary workWork at officeRemote workFlexible hours- Rochester Electronics, LLC in Rockville, MD seeks a Design Engineer IV (Staff) to lead high-profile silicon design projects created from original component manufacturers or customer databases. You will collaborate with Product Engineering and partner with test, packaging...
$110.7k - $379.2k
Position Summary Research Engineer — Post-Training & Small Language Models (SLMs), Healthcare AI Three hundred fifty million Americans... ...do real post-training at scale — committed investment in GPU compute and training infrastructure, not toy fine-tunes. As a Research...Local areaVisa sponsorship- A leading research university in Maryland is seeking an Assistant Research Scientist to contribute to a project focusing on drone communications for public safety applications. The role involves developing software solutions and evaluating communications technologies, requiring...
Do you want to receive more vacancies?
Subscribe and receive similar vacancies to Computational Protein Engineer. Be the first to apply!
