Senior Manager, Cost Accounting

Company Description

Guardant Health is a leading precision oncology company focused on guarding wellness and giving every person more time free from cancer. Founded in 2012, Guardant® is transforming patient care and accelerating new cancer therapies by providing critical insights into what drives disease through its advanced blood and tissue tests, real-world data and AI analytics. Guardant tests help improve outcomes across all stages of care, including screening to find cancer early, monitoring for recurrence in early-stage cancer, and treatment selection for patients with advanced cancer. For more information, visit guardanthealth.com and follow the company on LinkedIn, X (Twitter) and Facebook.


Inventory and Cost Accounting

• Own end-to-end inventory and cost accounting processes, including accurate month-end and quarter-end close, reconciliations, variance analysis, and reporting.
• Own COGS analytics and reporting, including development and maintenance of margin and variance analyses to support business decision-making.
• Oversee standard costing processes, including cost updates, revaluations, impact analysis, and investigation of significant variances.
• Analyze material, labor, external, and overhead costs to identify root causes and drive cross-functional, sustainable improvements.
• Define and report key cost and operational metrics, ensuring costing methodologies comply with GAAP and internal policies.

Inventory Management, Controls & Compliance

• Oversee cycle count programs and the year-end wall-to-wall physical inventory, ensuring compliance with SOX, GAAP, and company policies.
• Ensure inventory variances are timely investigated, reviewed, and properly recorded with appropriate audit documentation.
• Partner with Operations, Supply Chain, Quality, and R&D to ensure accurate inventory existence, valuation, and completeness.
• Serve as a primary contact for internal and external auditors; support inventory-related walkthroughs, testing, and remediation.
• Design, document, and maintain effective SOX controls related to inventory and cost accounting, driving continuous improvement in control effectiveness.

Systems, Process Improvement & Leadership

• Support the design and implementation of automated COGS reporting, partnering with IT and Data teams to improve accuracy, timeliness, scalability, and reduce manual effort.
• Drive ERP and system enhancements and process improvements to strengthen data accuracy, automation, and internal controls.
• Lead, mentor, and develop the cost accounting team; set clear expectations, provide coaching, and support professional growth.

Skills and Requirements:

• 8+ years of progressive experience supporting in-house manufacturing, preferably in a Lab Service Operations environment.
• Bachelor's degree in accounting, finance or related field; CPA or MBA a plus.
• Highly proficient in Microsoft Office, specifically Excel.
• Integrated MRP systems knowledge preferred.
• Extensive ERP experience, Oracle Fusion inventory and materials movement experience strongly preferred.
• A solutions-oriented team player who enjoys a dynamic work environment.
• Ability to communicate complex information in a clear and concise manner.
• Ability to effectively work with all levels and cross-functionally within the company including Senior Management.
• Strong analytical skills, with a sharp focus on details.

AI & Digital Fluency

• Demonstrate curiosity, sound judgment, and the ability to critically evaluate and responsibly leverage AI-enabled tools in accordance with company policies, ethical standards, and regulatory requirements to improve the efficiency, effectiveness, and quality of work.

Hybrid Work Model: This section is applicable to onsite employees who are eligible for hybrid work location as specified by management and related policies. Guardant has defined days for in-person/onsite collaboration and work-from-home days for individual-focused time. All U.S. employees who live within 50 miles of a Guardant facility will be required to be onsite on Mondays, Tuesdays, and Thursdays. We have found aligning our scheduled in-office days allows our teams to do the best work and creates the focused thinking time our innovative work requires. At Guardant, our work model has created flexibility for better work-life balance while keeping teams connected to advance our science for our patients.


The annualized base salary ranges for the primary location and any additional locations are listed below. This range does not include benefits or, if applicable, bonus, commission, or equity. Each candidate's compensation offer will be based on multiple factors including, but not limited to, geography, experience, education, job-related skills, job duties, and business need.Primary Location: Palo Alto, CAPrimary Location Base Pay Range: $163,800 - $225,250Other US Location(s) Base Pay Range: $139,230 - $191,463If the role is performed in Colorado, the pay range for this job is: $147,420 - $202,725

Employee may be required to lift routine office supplies and use office equipment. Majority of the work is performed in a desk/office environment; however, there may be exposure to high noise levels, fumes, and biohazard material in the laboratory environment. Ability to sit for extended periods of time.

Guardant Health is committed to providing reasonable accommodations in our hiring processes for candidates with disabilities, long-term conditions, mental health conditions, or sincerely held religious beliefs. If you need support, please reach out to View email address on click.appcast.io

A background screening including criminal history is required for this role. GH will consider qualified applicants with criminal arrest or conviction histories in a manner consistent with applicable law including but not limited to the LA County Fair Chance Policies and the Fair Chance Act (Gov. Code Section 12952).

Guardant Health is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

All your information will be kept confidential according to EEO guidelines.

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