Senior Director, Advanced Pharmacometrics, Quantitative Pharmacology and Pharmacometrics - Immuno-Oncology (Hybrid or Remote)

Merck seeks a Senior Director of Advanced Pharmacometrics to lead quantitative pharmacology strategy across its oncology portfolio. This scientific leader will oversee model-informed drug development initiatives, mentor quantitative scientists, and collaborate cross-functionally to advance oncology asset development from candidate nomination through registration.

Responsibilities

• Lead quantitative pharmacology strategy across oncology portfolio, ensuring alignment with program goals and organizational priorities
• Oversee development of advanced pharmacometrics models including population PK/PD, tumor dynamics, and survival modeling for dose selection and clinical design
• Lead, mentor, and develop team of quantitative scientists while fostering scientific rigor and innovation
• Collaborate with Clinical Development, Biostatistics, Regulatory, and Data Science to define modeling strategies informing key program decisions
• Prepare regulatory submissions, participate in scientific advice meetings, and represent company at industry conferences and consortia

Requirements

• Ph.D. in pharmacokinetics, pharmacodynamics, pharmacometrics, mathematics, statistics, or related discipline with 10+ years pharmaceutical experience
• Or Master's/PharmD with 15+ years pharmaceutical drug development and demonstrated leadership progression
• Extensive expertise in MIDD applications for oncology, population PK/PD, tumor dynamics, survival modeling, and Bayesian methods
• Hands-on proficiency with NONMEM, Pumas, Stan, R, and Bayesian modeling platforms
• Deep understanding of oncology biology, translational pathways, and clinical endpoints; experience across multiple modalities
• Demonstrated cross-functional collaboration and senior-level influence in matrixed environments
• Excellent written and verbal communication skills; preferred experience with AI/ML integration in pharmacometrics workflows