Senior Scientist, Antibody Engineering & Discovery (BMD)

Role OverviewThe BioMedicine Design (BMD) group at Pfizer Torrey Heights site is seeking a highly motivated Senior Scientist (R4) to contribute to the discovery and engineering of next-generation biologics, with an emphasis on multispecific antibodies like immune cell engagers (TCEs).This role will leverage yeast and phage display platforms to drive antibody discovery and optimization and will contribute to format engineering across immuno-oncology portfolios. A successful candidate will bring strong scientific rigor, execution excellence, and a collaborative mindset to advance programs from early discovery through candidate selection, delivering high-quality molecules for challenging targets. The candidate will have access to state-of-the-art protein and antibody engineering technologies and will be expected to continue our tradition of developing world-class methods and technologies that enhance our therapeutic discovery efforts.Key ResponsibilitiesDesign and execute antibody discovery/engineering campaigns using yeast/phage display technologies, including library construction, screening, and hit identificationImplement innovative strategies for the design and development of next-generation multispecific biologicsLeverage cross-functional data to define and drive molecular design and optimization strategies, collaborate across internal teams and external partners to drive efficient decision-making and program advancementContribute to platform development and continuous improvement of display technologies and screening strategiesClearly communicate results and scientific insights to project teams and leadershipStay informed with literature and scientific advancement in the biologics discovery and engineering fieldMaintain rigorous documentation and uphold high standards of scientific quality and data integrityBasic QualificationsPh.D. in Immunology, Molecular Biology, Protein Engineering, Chemical and Biomolecular Engineering or a related field, with postdoctoral trainingDemonstrated strong hands-on expertise in yeast display for antibody discovery and/or engineering, with creative problem-solving and solid analytical skills.Extensive technical skills in protein expression, purification and molecular biology.Strong publication record in peer-reviewed journals, reflecting scientific innovation and impactProven ability to independently design experiments, analyze complex datasets, and drive scientific decisionsExcellent work ethic, with strong ownership, attention to detail, and a commitment to high-quality executionPreferred QualificationsDemonstrated experience in project leadership within cross-functional teamsProven expertise in multispecific antibody design and production, including format engineering and expression strategiesWorking knowledge of computational tools supporting antibody discovery and engineering workflowsPrior experience in a matrixed drug discovery environment, ideally in biologics or antibody therapeuticsKey AttributesStrong scientific curiosity and problem-solving mindsetAbility to operate effectively in a fast-paced, collaborative environmentClear and concise communication skills, with the ability to influence cross-functional decisionsCommitment to BMD culture: collaboration, scientific excellence, and delivery for portfolio impact (“we better”)Work location assignment: On Premise. The annual base salary for this position ranges from $93,600.00 to $156,000.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 12.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States. Relocation assistance may be available based on business needs and/or eligibility. Candidates must be authorized to be employed in the U.S. by any employer.U.S. work visa sponsorship (such as TN, O-1, H-1B, etc.) is not available for this role now or in the future. Sunshine ActPfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative. EEO & Employment EligibilityPfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States. Pfizer endeavors to make accessible to all users. If you would like to contact us regarding the accessibility of our website or need assistance completing the application process and/or interviewing, please email View email address on click.appcast.io. This is to be used solely for accommodation requests with respect to the accessibility of our website, online application process and/or interviewing. Requests for any other reason will not be returned. To learn more about acceptable and prohibited uses of AI during the recruitment process, please review our candidate AI-use guidelines available on Pfizer Careers. Research and Development SummaryLocation: United States - California - San DiegoType: Full time