Principal Investigator
Metric Bio
Job Description
Principal Investigator – Psychiatry Clinical Research
Los Angeles, California
Metric Bio is partnered with a leading clinical research site network to appoint an experienced Principal Investigator with a strong background in Psychiatry studies.
This is an exciting opportunity to join a high-performing research organisation at the forefront of CNS and psychiatric clinical trials, supporting cutting-edge therapies across a diverse patient population in the Los Angeles area.
The Opportunity
As Principal Investigator, you will provide medical oversight across a broad portfolio of Psychiatry clinical studies, working alongside an established research infrastructure with dedicated coordinators, raters, and operational support teams.
The organisation has built a strong reputation for delivering complex CNS trials and offers access to a robust patient database, advanced research capabilities, and long-term study pipelines with global sponsors.
Key Responsibilities
- Serve as Principal Investigator across Phase I–IV Psychiatry clinical trials
- Ensure patient safety, protocol compliance, and regulatory oversight
- Conduct psychiatric evaluations and study assessments
- Collaborate closely with sponsors, CROs, and internal research teams
- Support patient recruitment and retention strategies
- Maintain high-quality standards in line with GCP and FDA regulations
- Provide leadership and mentorship within the clinical research team
Requirements
- MD or DO
- Active and unrestricted California medical license
- Prior experience as a Principal Investigator or Sub-Investigator in clinical research
- Strong understanding of CNS/Psychiatry trials
- Experience working within industry-sponsored studies preferred
- Passion for advancing innovative mental health treatments through research
Why Join?
- Join one of the most respected and rapidly growing research site networks in the industry
- Strong pipeline of Psychiatry and CNS studies
- Dedicated operational and recruitment support
- Competitive compensation package
- Opportunity to contribute to breakthrough mental health therapies
- Collaborative, patient-centric research environment
For a confidential discussion, please apply directly or contact - Oli Oldham - View email address on ziprecruiter.com for further information.
- ...adaptive governance systems with security-by-design that evolve as the threat landscape changes. The Opportunity We're seeking a Principal AI Security & Risk Researcher to join our founding research team and lead our security track. This isn't traditional red teaming or...PrincipalPart timeRemote workFlexible hours
$200k - $215k
A10 Networks, Inc. is seeking a Reverse Engineer specializing in IoT botnet malware. This role involves reverse engineering, dynamic malware analysis, and collaborating with product engineering on detection capabilities. You will engage directly with customers and lead ...Principal- A state governmental agency based in San Francisco is seeking a Senior Investigator. The role entails conducting complex investigations for clients facing capital convictions. Responsibilities include collecting and analyzing evidence, interviewing witnesses, and providing...Suggested
- Responsibilities Design, synthesize, and optimize FNLC materials for reflective e-paper displays Optimize bistability, reflectivity, response speed, temperature stability, and driving voltage Establish structure-property relationships; perform POM, DSC, dielectric, and...PrincipalRelocationOverseasRelocation package
$100k - $110k
A leading security services provider in San Francisco is seeking a Workplace Violence Investigator to be responsible for implementing California's workplace violence regulations. The ideal candidate will conduct investigations, develop training programs, and ensure all...Suggested- A government services firm in San Francisco seeks an experienced ACE Investigator to assist with fraud investigations for a Federal agency initiative. The role demands extensive investigative skills, collaboration with legal teams, and analysis of complex data sets. Successful...
$200k - $215k
...shipped detection capabilities. Lead external‑facing research: threat reports, technical blogs, and conference presentations. At principal level, you own the narrative and direction of research output. Engage directly with customers in post‑incident analysis, architectural...PrincipalFor subcontractorLocal area- An innovative tech platform is seeking a Senior Principal Software Engineer to lead the development of its next-gen API Platform. The role involves defining the technical vision, collaborating with various departments, and mentoring other engineers. The ideal candidate...PrincipalRemote work
$288k - $320k
...that achieving our goal requires real world deployment and iteratively updating based on what we learn. The Intelligence and Investigations team supports this by identifying and investigating misuses of our products - especially new and emerging classes of risk. This...Work at office$186k - $233k
Revolution Medicines is seeking an experienced Statistical Programmer with over 14 years in oncology trials. The role entails leading studies, collaborating with teams, and overseeing programming support for regulatory submissions in a dynamic environment. This opportunity...Principal- Airbnb, Inc. is seeking a Senior Principal in Marketing Strategic Finance & Analytics to lead financial strategy and analytics across marketing. This role involves budget management, KPI setting, and providing analytical insights to drive growth. Ideal candidates will have...Principal
$162.7k - $263.18k
...threat detection capabilities for Advanced Threat Prevention by decoding network protocols and identifying applications. As a Sr. Principal Security Researcher, you will shape detection methodologies, drive parallel projects, and influence detection strategy at scale. You...PrincipalFull timeWork at officeWorldwide- A consulting firm seeks a Managing Investigator to join its Executive Due Diligence team in San Francisco, CA. This role involves conducting complex investigations and managing cases with high standards of professionalism. The ideal candidate has 4-7 years of investigative...
$234k - $385k
...infrastructure by proactively identifying and disrupting adversaries who seek to compromise our systems or misuse our models. We investigate sophisticated threats, build tooling to scale and augment analysis, and deliver intelligence that shapes security strategy and equips...Remote workRelocationRelocation package- ...experience for our customers and supporting Airwallex’s mission to empower businesses globally. What you’ll do As a Senior Risk Investigator, you will play a critical role in identifying, analyzing, and mitigating risk across our product domains. You will be performing...Worldwide
$130 per hour
...HCRC), a San Francisco-based entity in the judicial branch of California's state government, is accepting applications for Senior Investigators. The HCRC provides direct legal representation to clients on death row in post-conviction proceedings, in state and federal...Work at office$157k - $281.93k
A leading design software company seeks a Senior Principal Content Strategist. This role involves defining content strategy for AI-driven experiences, partnering with cross-functional teams, and establishing content governance standards. Candidates should have over 12 years...Principal- Airwallex Pty Ltd. is seeking a Senior Risk Investigator in San Francisco to analyze and mitigate risk across its product domains. The candidate will conduct in-depth investigations into fraud and compliance violations while collaborating with cross-functional teams. This...
- A global financial technology company is seeking a Senior Risk Investigator based in San Francisco. This role involves identifying and mitigating risks associated with transactions, conducting detailed investigations on fraud and compliance violations, and collaborating...
$140k - $170k
Bloom Talent is seeking an experienced Executive Assistant to support the Principal in San Francisco. This in-office role involves managing a variety of responsibilities across executive support, real estate, financials, and project management. Candidates should have 7+...PrincipalWork at office- UCSF Health in San Francisco is seeking a skilled cardiac sonographer to perform complex fetal and pediatric echocardiograms. This role includes responsibilities such as high-quality ultrasound tests, training staff, and maintaining accreditation. The ideal candidate will...PrincipalFlexible hours
- I did my part and supported the Regular Toilet seeks a Principal User Researcher in San Francisco. You'll collaborate with diverse teams to drive product direction through user insights, focusing on web 3, crypto, and blockchain. The ideal candidate has over 10 years of...PrincipalFlexible hours
$141k - $188k
Biogen, Inc. is seeking a Senior Principal Analyst in San Francisco, responsible for leading statistical programming activities in clinical trials. This role involves managing programming deliverables, ensuring compliance with standards, and collaborating with internal...Principal$197.3k - $313.7k
Salesforce.com, inc. is looking for a Principal Insider Threat Analyst in San Francisco, CA. This role is central to maturing the Insider... ...in cybersecurity and proven leadership in insider threat investigations. The candidate must possess deep knowledge of malicious...$260k - $275k
Saviynt, located in San Francisco, is hiring a Senior Principal Software Engineer to lead the development of our AI security products. You will design and implement secure and scalable workflows, work across various cloud platforms, and contribute to product direction and...Principal- Holthouse Carlin & Van Trigt LLP in San Francisco offers a dynamic hybrid work model, seeking a seasoned Tax Manager. The role involves overseeing federal and multi-state income tax returns, leading teams, ensuring quality, and advising clients on tax issues. The ideal ...Principal
- Lila Sciences in San Francisco is looking for a founding Sr. Principal / Distinguished ML Scientist for its new AI for Cell Biology team. This senior leadership role focuses on developing autonomous-science capabilities and integrating cell-biology research with Lila's...PrincipalFull time
- A biotechnology company is seeking a Senior Principal Biostatistician in San Francisco to lead study design and provide statistical expertise. You will perform analyses and contribute to critical projects in nephrology. Candidates must possess a PhD in Biostatistics and...Principal
$261k - $326k
A technology company specializing in AI infrastructure is seeking a Principal Engineer to enhance reliability and scalability of cloud systems. This role demands over 15 years of experience in production engineering or related fields and involves setting technical directions...Principal- A beverage company in San Francisco is looking for a Sr. Principal Product Owner to lead their integration services product. This role emphasizes the ownership of the integration roadmap and managing a blended delivery team. The ideal candidate will possess a Bachelor's...Principal
Do you want to receive more vacancies?
Subscribe and receive similar vacancies to Principal Investigator. Be the first to apply!
- insurance investigator San Francisco, CA
- corporate security investigator San Francisco, CA
- employee relations investigator San Francisco, CA
- research investigator San Francisco, CA
- housing investigator San Francisco, CA
- senior investigator San Francisco, CA
- case investigator San Francisco, CA
- aml investigator San Francisco, CA
- investigator San Francisco, CA
- opm background investigator San Francisco, CA

