Senior Director, Program Leader

At Agios, we are fueled by connections to transform rare diseases. We foster an inclusive, collaborative culture – one that sparks bold thinking and strengthens our connections with each other and with the rare disease communities we serve. We embrace diverse backgrounds with respect, active listening, and a commitment to inclusion – because our differences shape how we hire, collaborate, and innovate. Our team’s proven track record of executional excellence, combined with our depth of expertise and dedication, enables us to develop innovative medicines that reflect the priorities of rare disease communities. Our commitment is more than scientific – it’s deeply personal, grounded in the meaningful connections we have built. To learn more, visit and follow Agios on LinkedIn and X.

The impact you will make:

Agios Pharmaceuticals is searching for a visionary and strategic Program Leader to serve as the single point of accountability for one of our critical clinical stage programs. This is a rare opportunity to function as the strategic and operational architect of a clinical stage asset, owning its vision and driving its execution from clinical development through regulatory approval, global launch, and lifecycle management. As the Program Leader, you will lead the Program Team, aligning a high-performing cross-functional organization around a unified strategy designed to deliver transformative therapies to patients with rare diseases. You will be a decisive, globally-minded leader who thrives at the intersection of science, strategy, and execution — equally comfortable engaging with Senior Leadership and rolling up your sleeves to resolve complex challenges.

What you will do:

• Own the fully integrated global asset strategy across the entire product lifecycle — from development candidate through clinical proof of concept, regulatory approval, commercial launch, and lifecycle management — ensuring alignment with Agios’ portfolio and corporate objectives.
• Define and continuously evolve the Target Product Profile, Clinical Development Plan, regulatory pathway, market access strategy, and commercial positioning in close partnership with cross-functional leaders and aligned with patient needs.
• Identify, assess, and proactively communicate program risks and opportunities to senior leadership and governance bodies, developing clear mitigation strategies and scenario-based contingency plans.
• Lead asset presentations at governance meetings to senior leadership, securing endorsement, budget, and resource allocation through rigorous analysis of strategic options, return on investment, and risk.

Cross-Functional Leadership & Execution

• Lead the Program Team, building a cohesive, high-performing cross-functional team that includes, but is not limited to, Clinical Development, Regulatory Affairs, Commercial, Medical Affairs, Manufacturing/CMC, Market Access, Finance, Legal, and Program Management.
• Partner closely with the Program Manager to develop integrated execution plans, timelines, and resource requirements; maintain accountability for delivering against program goals, milestones, and budgets.
• Drive timely, well-reasoned decision-making across the organization, using governance structures effectively to resolve complex tradeoffs and keep programs on track.
• Ensure that all key program documents reflect full cross-functional input and are kept current.

Regulatory Strategy & Commercial Alignment

• Partner with Regulatory Affairs to guide the global regulatory strategy, including planning and preparation for interactions with the FDA, EMA, and other major health authorities; experience with and understanding of NDA/BLA or equivalent submissions is central to this role.
• Ensure alignment of the development plan with commercial objectives, partnering with the Commercial team to anticipate market access challenges and build a globally competitive value proposition.
• Collaborate with Medical Affairs and Clinical Development to define and execute the asset’s publication and data dissemination strategy across major scientific congresses and peer-reviewed journals.
• Anticipate and navigate evolving regulatory and reimbursement landscapes globally, incorporating external insights into program strategy.

Stakeholder & External Engagement

• Serve as a key internal champion and external representative for the asset, partnering with relevant functions to engage key opinion leaders, patient advocacy organizations, potential partners, and the broader scientific community.
• Partner with Investor Relations and Corporate Communications to develop and manage external messaging for the analyst community in collaboration with the clinical development lead.
• Collaborate with Business Development to evaluate and pursue lifecycle opportunities including partnerships, in-licensing, and co-development alliances that enhance the asset’s value.

Organizational Leadership & Culture

• Model Agios’ values and culture — cultivating an environment of collaboration, intellectual courage, and patient focus throughout the Program Team.
• Communicate with clarity, candor, and executive presence to all levels of the organization, from Program Team members to senior leadership.
• Recruit, coach, and develop team members across the cross-functional Program Team, expanding capability and leadership depth within the organization.

What you bring:

• Advanced degree (MD, PhD, PharmD, MBA, or equivalent); graduate-level scientific or clinical training strongly preferred given the depth of development expertise required.
• 10+ years of progressive experience within the pharmaceutical, biotechnology, or biopharma industry, including demonstrated leadership of late-stage or registration-enabling clinical programs.
• Demonstrated ability to drive successful product launch and commercialization of innovative, first-in-class therapies, including lifecycle management (LCM) planning and execution; experience leading programs from late-stage development through commercial readiness and post-launch LCM strategies strongly desired.
• Deep expertise in drug development across multiple functional domains including clinical development, regulatory strategy, CMC, medical affairs, and commercial readiness — rare disease experience strongly desired.
• Proven track record as a decisive, strategic leader in a global matrix organization, with demonstrated ability to lead through influence rather than direct authority.
• Experience leading cross-functional global program teams through major regulatory milestones, including NDA/BLA or equivalent submissions; interactions with FDA, EMA, and/or other major health authorities.
• Strong business acumen with experience integrating program plans into long-range corporate strategy, portfolio prioritization, and financial planning; ability to develop and present investment cases clearly and compellingly to senior leadership.
• Demonstrated ability to manage and synthesize complex scientific, clinical, regulatory, and commercial information and translate it into clear strategic direction.
• Exceptional communication skills — both written and verbal — with the ability to convey nuanced scientific and strategic content to diverse audiences including executives, investors, regulators, and patient communities.
• Track record of building and motivating high-performing teams, developing talent, and driving organizational alignment across complex, matrixed environments.
• Global mindset with experience managing programs across multiple geographies, health systems, and regulatory jurisdictions.

Work Location:

Location Specific – Hybrid:

This role requires some work onsite at our Cambridge Headquarters as needed. Hybrid schedules vary but are generally less than 3 days per week onsite. Regular conversations with manager are encouraged to ensure alignment on in-person presence/expectations. Employees in this role are expected to live within a commutable distance to the office and some travel may be required commensurate to the above job description and/or to attend team meetings and other company events.

What we will give you:

• Deliberate Development. Your professional growth as one of our top priorities.
• Flexibility. We’re all about individual needs. We embrace different perspectives, work styles, health and wellness approaches, care of families and productivity. When you’re at your best, we’re at our best.
• Premium benefits package. We invest in the health, wellbeing, and security of our people with a premium benefits package that is well-rounded and flexible to help meet the varied personal and professional needs of every member of our team. For more detail on the benefits we offer at Agios, visit the Inside Agios section of our website.
• Competitive and equitable performance-based compensation. This includes base salary and both short- and long-term incentives that are connected to our business strategy and vary based on individual and company performance.
• The current base salary range for this position is expected to be between $229,562 and $344,345 annualized; final salary will be determined based on various factors including, but not limited to, years of relevant experience, job knowledge, skills and proficiency, degree/education, and internal comparators.
• Psychological safety. We support an environment of fearlessness. We want you to share your ideas, speak candidly and take data-informed risks to help push the boundaries.
• Commitment to diversity. We strive to foster a welcoming workplace where everyone can thrive. We’re continuously looking to improve the inclusivity of our workforce.
• Commitment to community. We’re an active participant in the communities that surround us – the communities where we live, and the community of people and their loved ones in need of better treatment options for conditions that are often overlooked.

Interested in learning more about what makes our culture unique? Visit the Inside Agios section of our website.