Head of Clinical Development Boston, MA

About Every Cure Every Cure is an AI-driven nonprofit, biotech organization on a mission to save and improve lives by repurposing existing medicines for diseases with significant unmet need. We work to create a world where every drug can treat every disease it possibly can, ensuring no patient suffers when an existing treatment could help them. Our Approach AI-Powered Identification : We use artificial intelligence to analyze biomedical knowledge and identify FDA-approved drugs that can be repurposed for untreated conditions. Open-Source Commitment : Our predictive pipeline is open-source, fostering collaboration and transparency. High-Impact Focus : We prioritize repurposing opportunities that relieve the most suffering with the greatest impact. Rigorous Validation : Promising opportunities are validated through laboratory and clinical studies before broader application. Strategic Marketing and Access : We disseminate effective repurposed treatments and commit to ensuring new cures are accessible to all patients. Applicants must reside in the state specified at the top of this job posting. Head of Clinical Development The Head of Clinical Development (HCD) leads Every Cure’s clinical research and development function. The role serves as both strategic architect and hands‑on clinical lead on priority programs, managing a diverse portfolio of drug repurposing initiatives, collaborating directly with computational and data science teams, and representing the organization to external partners and stakeholders. Key Responsibilities Strategic Leadership : Set direction for clinical research, align with the mission, lead or co‑lead priority programs, and oversee operational planning, quality, and accountability. Research & Clinical Development Oversight : Design, author, and review study documents; serve as sponsor medical lead; translate findings into program decisions; ensure compliance with human subjects research and safety reporting. Portfolio Strategy & Program Management : Prioritize and manage the diverse portfolio; lead CRO and vendor selection and governance; allocate resources across disease areas. Leadership & Team Development : Build, mentor, and lead a lean high‑performing team; define roles and performance standards; promote continuous learning. Stakeholder Engagement & Dissemination : Act as medical spokesperson and regulatory interface; cultivate partnerships; guide regulatory approval and post‑study dissemination. Required Education MD or MD/PhD preferred; PhD, DO, or PharmD acceptable. Required Experience (Head of Clinical Development) 8+ years of clinical development experience post‑MD (or equivalent), including leading a sponsor‑held Phase 2 trial from protocol to database lock. Demonstrated leadership in recruiting, mentoring, and managing cross‑functional clinical teams. Expertise in drug development, clinical trial design, and clinical decision‑making. Sponsor‑side experience running Phase 2 trials. Experience across multiple therapeutic research areas and with small‑sample trial designs or natural‑history/registry data. Proven leadership in driving strategic initiatives and cross‑functional collaboration. Preferred for Vice President Designation 12+ years of clinical development experience with prior functional leadership at a sponsor, multiple sponsor‑held INDs through Phase 2 or beyond, and experience with REMS programs or similar complex regulatory programs. Key Skills Proficiency in clinical research, real‑world evidence assessments, evidence generation, patient registry design, and sponsor‑side pharmacovigilance. Working knowledge of FDA IND regulations, ICH E6(R3), ICH E9, 21 CFR Part 11, and REMS requirements. Exceptional communication and presentation abilities. Ability to foster a collaborative, cross‑functional culture grounded in the mission and values. Strong partnership skills with computational and data science teams and critical evaluation of AI/ML-driven hypotheses. Strategic thinker focused on urgency, efficiency, and impact; passionate about Every Cure’s mission; highly adaptable in a fast‑paced start‑up environment. Explicit willingness to be hands‑on, authoring key clinical documents, managing vendors, and working alongside junior staff. Compensation & Benefits Competitive salary: $250,000 – $275,000 annually (based on experience). Health and wellness: comprehensive medical, dental, vision coverage and a Flexible Spending Account. 403(b) retirement plan with 3.5% employer match. Generous time off: paid leave, holidays, family and medical leave. Location Cambridge, MA. Minimum 3 days per week in office. EEO Statement Every Cure is an Equal Opportunity Employer. We celebrate diversity and are committed to creating an inclusive environment for all employees. We provide equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, national origin, age, disability, genetics, or any other characteristic protected by federal, state, or local laws. #J-18808-Ljbffr