Associate Director, R&D Chemistry, Peptidomimetics

Associate Director (Peptidomimetics), R&D Chemistry We are currently seeking an established leader and drug hunter for the R&D (Research & Development) Chemistry group. In this position, they will play a key role in expanding Regeneron's peptidomimetic antibody‑conjugate drug discovery capabilities, while providing innovation and leadership to seamlessly combine with the company’s existing expertise in biologics and novel genetic medicines. The candidate will drive the discovery of peptidomimetic antibody conjugate drug therapeutics across diverse research areas. Cultural fit with the Regeneron cross‑functional teams will be a key driver for success. Build Our Future Together Directly supervise and manage the day‑to‑day activities of the R&D Chemistry Peptidomimetic group, providing vision, inspiration, and both short‑term and long‑term goals. Communicate priorities, policies, and goals of Regeneron Senior Leaders to the group. Perform medicinal chemistry inspired and SAR‑driven generation of novel peptidomimetic drug modalities, using synthetically feasible and simplistically designed linkers to provide overall optimal in vitro and in  vivo properties of antibody‑conjugated therapeutics. Troubleshoot and optimize peptide potency and stability using standard peptide‑based principles (e.g., Ala scans), non‑natural amino acid incorporation, alpha‑Me/N‑Me peptide backbone modifications, and other medicinal chemistry strategies guided by in vitro assays, plasma/serum stability, and met ID data. Champion and lead the R&D Chemistry Peptidomimetic efforts on internal/external project teams, and demonstrate the ability to multi‑task and parallel process to add to our continuous pipeline of Regeneron development candidates. Identify new strategies and technologies (e.g., linker and payload design) to improve on existing Regeneron platforms for pursuing novel synthesis and bioconjugation of peptidomimetic drug modalities. Actively participate in departmental, cross‑functional, leadership, and external meetings to contribute expertise and represent the vision of the R&D Chemistry Peptidomimetic group. Interact broadly and collaboratively with other Regeneron groups, forging relationships and active collaborations. When & Where This is an on‑site position located in our Hawthorne, NY facility. Occasional travel to our nearby Tarrytown facility may be required. Discover Your Role You are passionate and enthusiastic about the promise of peptidomimetic conjugated, antibody‑targeted therapeutics and appreciate the challenges and opportunities of drug delivery and molecular targeting. You enjoy applying and combining traditional methods and novel technologies to develop solutions for synthesis, bioconjugation and drug discovery. You are comfortable working in a cross‑functional role and excel as part of a diverse team where egos are checked at the door. You want to provide meaningful contributions to the development of an organizational culture that supports growth and development of its people and capabilities to drive forward the Regeneron pipeline. You prefer to work in an organization that is modality agnostic, letting the data determine the best course forward. In order to be considered qualified for the role, you must have: Ph.D. in peptide and/or synthetic organic chemistry or a related field. Minimum of 10 years of professional industry experience. Extensive drug discovery experience with antibody‑targeted peptidomimetic drug modalities, experience with the synthesis and manufacturing of peptidomimetic payloads and linkers, expertise in modern methods in medicinal chemistry structure‑activity relationships, and a deep understanding of biological MOAs (extracellular/intracellular target evaluation, ADME/PK, PD/efficacy, toxicological evaluation). A track record of success in the field of either peptidomimetics, small molecules or antibody‑targeted therapeutics (i.e., advancement of molecules into the clinic) with experience building and leading teams is required. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, sexual orientation, gender identity or expression, gender reassignment, marital or civil partnership status, civil status, pregnancy or parental status, age, disability, nationality, citizenship status, ethnic or national origin, membership of the Traveler community, familial status, genetic information, military or veteran status, or any other characteristic protected under applicable law. Where required, we will provide reasonable accommodation to applicants with known disabilities or chronic illnesses during the recruitment process, unless such accommodation would impose undue hardship. Salary Range (annually): $176,100.00 - $287,300.00 #J-18808-Ljbffr BioSpace