Scientist, In Vivo Pharmacology

Key Responsibilities In vivo study execution Establish and run CDX efficacy studies — tumor cell preparation and implantation (subcutaneous and, where relevant, orthotopic), enrollment, randomization, and study monitoring. Administer test articles by multiple routes (IV, IP, SC) with accurate dosing, and maintain precise dosing records. Collect tumor-volume and body-weight measurements on schedule, monitor animal health, and recognize and elevate clinical observations promptly. Perform terminal procedures and collect blood and tissue samples for PK, PD, and biomarker analysis. Dose-range finding and dose fractionation Design and execute dose-range-finding (DRF) studies to define active and tolerated dose levels for ADC candidates. Run dose-fractionation studies that compare dose level versus schedule, helping distinguish exposure-driven from schedule-driven activity and tolerability. Partner with the Director and DMPK to align dosing and sampling schedules so efficacy, exposure, and tolerability read out cleanly from the same study. Data, compliance, and operations Record, plot, and summarize tumor-growth and body-weight data; generate clear growth curves and study summaries. Maintain meticulous study documentation and data integrity, and follow all IACUC protocols and animal-welfare requirements. Manage study logistics — cell-line readiness, animal ordering and acclimation, dosing formulations, and scheduling. Contribute to SOPs and help improve in vivo workflows and reproducibility. Qualifications Required BS with 4+ years, or MS with 2+ years, of hands‑on in vivo oncology experience in a biotech, pharma, or CRO setting. Demonstrated proficiency in rodent handling, tumor implantation, multi-route dosing (IV/IP/SC), tumor measurement, and terminal procedures. Experience running xenograft (CDX) efficacy studies and collecting PK/PD samples. Strong record‑keeping, attention to detail, and comfort with data entry and basic analysis (e.g., Excel, GraphPad Prism). Current or obtainable IACUC training and a genuine commitment to animal welfare. #J-18808-Ljbffr Planet Pharma