Postdoctoral Fellow-MSH-30040-232

Web link to Department:

Administrative Contact: (phone and email): Yoori Kim, Show phone number, View email address on careers.mountsinai.org

Details of Research Project: 

Dr. Jian Jin’s lab is a leader in discovering selective inhibitors of protein methyltransferases (PMTs), biased ligands of G protein-coupled receptors (GPCRs), and small-molecule degraders of oncoproteins and stabilizers of tumor suppressors, as well as in developing innovative technologies for advancing the targeted protein degradation (TPD), targeted protein stabilization (TPS), and targeted protein acetylation (TPA) fields. This chemical biology and drug discovery project will involve design, synthesis, and testing of new compounds to develop novel therapeutics for treating various human diseases including cancer as well as development of new technologies to advance the research fields described above.

Technical Duties: 

The main responsibilities include: (1) design and synthesize molecules of interest; (2) perform analyses to confirm the identity and purity of the synthesized products; (3) test the synthesized compounds in biochemical and cellular assays, (4) analyze data and prepare reports for review with Dr. Jian Jin and other lab members; (5) document all work according to standard procedures; (6) prepare or contribute to publications and grant applications; (7) prepare and present materials at seminars and meetings; (8) comply with all safety rules; and (9) maintain the lab equipment related to the research.

Educational and other Requirements for the position: PhD

Administrative Contact: (phone and email): Yoori Kim, Show phone number, View email address on careers.mountsinai.org

Educational and other Requirements for the position: PhD

Experience Required:

Experience in synthesis of small molecules by using parallel, multistep synthetic organic chemistry techniques is required. Experience in small molecule purification via chromatography techniques such as flash column chromatography and liquid chromatography as well as techniques in characterization of the small molecules via NMR and LCMS is required. Experience in testing compounds in biochemical and cellular assays is also required

Goals/Outcomes of the Research Project: 

Successful outcome of the project would be discovery of novel compounds as chemical biology tools and/or preclinical drug candidates to study and/or treat human diseases such as cancer and publication of research results to advance relevant research fields.

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Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 48,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time — discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it. Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients’ medical and emotional needs at the center of all treatment. The Health System includes more than 9,000 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Report's Best Hospitals, receiving high "Honor Roll" status, and are highly ranked: No. 1 in Geriatrics, top 5 in Cardiology/Heart Surgery, and top 20 in Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. U.S. News & World Report’s “Best Children’s Hospitals” ranks Mount Sinai Kravis Children's Hospital among the country’s best in several pediatric specialties. The Icahn School of Medicine at Mount Sinai is ranked No. 11 nationwide in National Institutes of Health funding and in the 99th percentile in research dollars per investigator according to the Association of American Medical Colleges. Newsweek’s “The World’s Best Smart Hospitals” ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally.

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Compensation

The Mount Sinai Health System (MSHS) provides salary ranges that comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $72500 - $80000 Annually. Actual salaries depend on a variety of factors, including experience, education, and operational need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.