Scientific Software Developer - Affinity

Over the last eight years, OpenEye Scientific has developed the field’s most advanced large-scale compute platform, Orion, built on Amazon Web Services. In this position you will be working at the cutting edge of cloud computing, C++/Python development, and advanced MD simulation techniques. Your work will have the potential to make a major impact in drug discovery and will be available to many pharmaceutical and biotech companies. OpenEye, Cadence Molecular Sciences, is an industry leader in computational molecular design. We use a scientific approach to deliver rapid, robust, and scalable software, toolkits, and technology & design services for the advancement of pharmaceuticals, biologics, agrochemicals, and flavors and fragrances. The Affinity Group at OpenEye seeks a scientific software developer to join a growing team delivering Molecular Dynamics (MD) based solutions for predicting protein-ligand binding affinities. Within OpenEye’s cloud-based platform Orion, our team has delivered massively parallel Relative Binding Free Energy (RBFE) tools capable of calculating affinities on dozens of ligands in only hours, using hundreds of GPUs. We are also developing faster, higher throughput MD-based prescreening approaches to use upstream of the heavier free energy methods. With your experience in MD and programming you will help us extend our capabilities, making our science and tools more robust, accurate, and efficient. Qualifications PhD. with PostDoc in an area related to structure-based ligand design methods. 3 or more years of experience in scientific programming with Python. 3 or more years of experience with Molecular Dynamics including Free Energy Calculations. Experience in computational chemistry methods development, implementation, and validation. Team-oriented with good communication skills and professional scientific presentation skills. Ability and desire to learn new ideas and adapt to new development practices. Preferred (but not required) Knowledge & skill in programming and professional software development practices & tools. Experience with a multi-platform and/or distributed computing environment including cloud computing. Knowledge of chemistry and/or drug discovery & development. Benefits Medical, dental, and vision coverage. Flexible working schedule. 401(k) retirement plans. Paid vacation and paid sick leave. Home internet costs covered. Public transportation reimbursement. Competitive total compensation package. #J-18808-Ljbffr