Associate Director, Clinical Pharmacology

Role Summary Exciting opportunity in Clinical Pharmacology! Our Clinical Pharmacology Team is looking for an Associate Director to support the exciting portfolio in Internal Medicine. Our team members champion the innovative use of MIDD for efficient drug development and robust decision‑making. A great environment for learning and professional growth! Our Clinical Pharmacology Leads have key roles to play in influencing the discovery and development of drugs. Pfizer is a leader in model‑informed drug discovery and development (MIDD), and we are expanding in influence and impact. We have an open position as Clinical Pharmacology Lead supporting our End‑to‑End Internal Medicine portfolio. The ideal candidate is responsible for providing the clinical pharmacology and MIDD components of clinical plans and providing clinical pharmacology expertise to the project team and regulatory interactions. Working with a multifunctional study team, Clinical Pharmacology Leads utilize innovative methods to integrate knowledge of pharmacokinetics, pharmacodynamics, patient characteristics and diseases for rational development strategies and decisions, as well as optimal study designs and dosage regimen selections. Responsibilities Act as Clinical Pharmacology representative on Clinical Sub Team, Development Team, and other multifunctional teams as appropriate. Provide expertise, leadership, and deliverables of clinical pharmacology for the assigned projects within the sphere of influence. Design and execute clinical pharmacology plans and implement best practices on project teams. Work closely with other disciplines to ensure that sufficient preclinical PK/PD knowledge exists to underwrite safe human administration and to establish the structure of a predictive model prior to FIH. Plan and oversee clinical pharmacology aspects at the project level, including development plans, interpretation of PK/PD analyses, and PK/immunogenicity/biomarker measurement strategies. Plan and oversee study‑level activities, including protocol authoring, clinical phase oversight, and reporting. Collaborate with clinicians and statisticians to ensure appropriate dose‑range‑finding strategies that lead to optimal doses and dosage regimens in patients. Ensure appropriate design and implementation of an End‑to‑End MIDD plan that conforms with best practices. Use innovative analytical methods to integrate knowledge of PK, PD, patient characteristics, and disease states to optimize doses, dosage regimens, and study designs. Contribute to regulatory documents (e.g., briefing documents, regulatory queries, Investigator’s Brochures, IND, NDA/MAA). Develop new methodologies through internal and/or external collaborations with world‑leading experts. Coach less experienced colleagues and team members. Stay abreast of literature, regulatory guidelines, and internal SOPs. Influence external environment through publications, presentations, and representation at scientific societies and industrial consortiums. Qualifications Demonstrated breadth of diverse leadership experiences, including influencing and collaborating with peers, developing and coaching others, and overseeing and guiding team work to achieve meaningful outcomes. Strong quantitative skills and expertise in mechanistic PK/PD modeling, systems pharmacology, literature meta‑analyses, population modeling, and clinical trial simulations using NONMEM, R, etc. M.D./Ph.D., or equivalent training and experience in pharmacokinetics, pharmacometrics, clinical pharmacology, engineering, or a related discipline. Minimum 1 year of industry experience in clinical pharmacology, PK/PD, pharmacometrics, or systems pharmacology. Minimum 5 years of industry experience in clinical pharmacology and related fields. Intimate knowledge of drug development and experience applying quantitative pharmacology approaches to knowledge integration. Excellent written and verbal communication skills and demonstrated presentation skills. Ability to attend global meetings periodically across different time zones. Compensation and Benefits The annual base salary for this position ranges from $139,100.00 to $231,900.00. The role is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 17.5% of the base salary and eligibility to participate in a share‑based long‑term incentive program. Benefits include a 401(k) plan with Pfizer matching contributions and an additional retirement savings contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits covering medical, prescription drug, dental, and vision coverage. Location and Travel This is a hybrid role. Candidates must live within commuting distance and work on‑site an average of 2.5 days per week or more as needed. Eligible for a relocation package and employee referral bonus. There is no U.S. work visa sponsorship (TN, O‑1, H‑1B) available for this role now or in the future. Equal Opportunity Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or expression, national origin, disability or veteran status. Pfizer complies with all applicable national, state and local nondiscrimination laws and requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E‑Verify employer. This position requires permanent work authorization in the United States. #J-18808-Ljbffr