Scientist I, Analytical Development

Company Overview ImmunityBio is a vertically integrated commercial stage biotechnology company developing next-generation therapies that bolster the natural immune system to defeat cancers and infectious diseases. The Company's range of immunotherapy and cell therapy platforms, alone and together, act to drive and sustain an immune response with the goal of creating durable and safe protection against disease. Designated an FDA Breakthrough Therapy, ANKTIVA is the first FDA-approved immunotherapy for non-muscle invasive bladder cancer CIS that activates NK cells, T cells, and memory T cells for a long-duration response. The Company is applying its science and platforms to treating cancers, including the development of potential cancer vaccines, as well as developing immunotherapies and cell therapies that we believe sharply reduce or eliminate the need for standard high-dose chemotherapy. These platforms and their associated product candidates are designed to be more effective, accessible, and easily administered than current standards of care in oncology and infectious diseases. Why ImmunityBio? ImmunityBio is developing cutting-edge technology with the goal to transform the lives of patients with cancer and develop next-generation therapies and vaccines that complement, harness and amplify the immune system to defeat cancers and infectious diseases. Opportunity to join a publicly traded biopharmaceutical company with headquarters in Southern California. Work with a collaborative team with the ability to work across different areas of the company. Ability to join a growing company with professional development opportunities. Position Summary The Scientist I, Analytical Development, will work as part of the Analytical and Process Development team. The role will assist in developing, optimizing and validating bioassays to support cell therapy projects and will be responsible for supporting the efficient operation of the laboratory and performing scientific studies to support cell therapy projects. Essential Functions Perform cell-based assays to support Process development studies for different cell therapy projects. Develop and qualify potency assays including cytotoxicity, cell proliferation assays and ADCC assays. Maintain, calibrate and operate cell analytical equipment and instruments. Develop standard operating procedures, analytical test methods, analytical sampling plans and batch records. Provide support to cross-functional team to advance development of NK cell therapy products. Develop or adapt analytical methods for cell therapy products and develop process improvements and efficiencies. Design and execute method development and qualification in support of lead candidate selection, process development, product release and stability, and product characterization. Train team members on optimized procedures. Design and execute experiments to develop, qualify, and transfer cell-based potency methods for the testing and release of pipeline products. Performs ad-hoc and cross-functional duties and/or projects assigned to support business needs and provide developmental opportunities. Education & Experience Bachelor's degree with 8+ years' experience in Immunology, cell biology, biochemistry or biological sciences required, or Master's degree with 5+ years of experience in Immunology, cell biology, biochemistry or biological sciences required. Experience with immunoassay technologies such as flow cytometry, ELISA and MSD and molecular assays (DD-PCR, RT-qPCR) to support the characterization of NK or T cells required. Experience with cell therapy products including NK cells is a plus Experience working in an immunology laboratory (preferably working with primary cells and cell lines) preferred Experience with multiple flow-cytometer platforms is a plus. Knowledge, Skills, & Abilities Proficient in handling and maintaining mammalian cell culture in a BSL2 Laboratory is required. Demonstrated knowledge of pharmaceutical manufacturing of biotechnology products, aseptic processing, analytical method development, technology transfer, method qualification/validation and process development Ability to follow laboratory procedures with attention to detail and successfully execute experiments at the bench. Knowledge in flow-cytometry. Comfortable in a fast-paced small company environment with minimal direction and able to adjust workload based upon changing priorities. Self-motivated and detail-oriented Ability to think critically and demonstrate troubleshooting and problem-solving skills. Excellent interpersonal, verbal and written communication skills Excellent skill in Microsoft word, Excel and data analysis Working Environment / Physical Environment This position works on site in Torrey Pines, CA. This position is in a lab environment. This position does bench work in a laboratory Frequently working on a computer for data analysis Occasionally lifts 11 - 20 lbs. This position is eligible for a #J-18808-Ljbffr nant