Manager, Clinical Business Operations

Job Description

Job Description

The START Center for Cancer Research (“START”) is the world’s largest early phase site network, fully dedicated to oncology clinical research. Throughout our history, START has provided hope to cancer patients in global community practices by offering "Hope Through Access” to cutting edge trials throughout the United States and Europe.

 

Position Summary:

The Manager, Clinical Business Operations is a site-embedded role responsible for ensuring the integrity and accuracy of clinical activity data recorded in START's systems of record. Primary systems include OnCore (CTMS), Aria (EMR), eDAR (pharmacy tracking), Filemaker, NetSuite (financial tracking), and sponsor-owned EDC platforms. This role holds primary accuracy responsibility for CTMS and Filemaker data, and coordinates with Aria and eDAR.

This role coordinates with EDC systems and serves as the primary interface between the clinical site and START's finance and operational leadership on all matters related to activity documentation, data accuracy, invoicing disputes, and revenue recovery. The role operates at the intersection of clinical operations and financial accountability, ensuring that every billable activity performed at the site is captured correctly, confirmable on demand, and collectable.

Work Schedule: M-F, 8:00am-5:00pm

Location: 4383 Medical Dr, San Antonio, TX 78229, United States

Essential Responsibilities:

Clinical Activity Data Integrity

• Ensure that all clinical activity performed at the site in support of a clinical protocol is accurately and completely recorded in CTMS (OnCore) and Filemaker in a timely manner.
• Bridge the translation between clinical documentation and billing system entry.
• Ensure site clinical and operational data supporting START financial processes adheres to Master Data Management Governance standards.
• Monitor adherence to operational and financial controls established by START operational leadership to maintain clinical activity data integrity across all active protocols.
• Identify and investigate data discrepancies where system records do not accurately reflect activity performed at the site. Initiate and document corrections in compliance with applicable site SOPs and regulatory requirements, with appropriate notification to the relevant protocol team and QA function.
• Track and trend data quality metrics, error rates, and invoice rejection patterns at the site level. Maintain a running record of recurring issues, root causes, and resolution actions. Report findings and improvement recommendations to the Director, Study Operations and revenue cycle leadership on a defined cadence.
• Participate in pre-study activation revenue cycle huddles for every new study and major amendment. Review CTMS build structure, budget overlay, and charge master mapping alongside Study Administration, revenue cycle, and site operations teams before first patient enrollment to prevent downstream billing errors. Capture and document key decisions in CTMS for reference as additional sites activate.

Sponsor Dispute Resolution and Invoice Support

• Serve as the site's primary subject matter resource when a customer (sponsor or CRO) disputes an invoice for accuracy or declines payment; provide finance and operational leadership with the specific site-level activity data needed to confirm or correct the invoiced services.
• Support downstream financial billing, accounts receivable, and collections processes by providing documentation and data confirmation required to support collections and secure cash receipt.
• Support downstream financial billing and accounts receivable processes by facilitating timely correction of the source activity data and resubmission of accurate invoicing.

Finance and Operations Partnership

• Monitor accounts receivable status for site protocols; track whether invoices are being paid, identify aging or disputed items, and escalate unresolved payment issues through Study Administration and revenue cycle channels.
• Troubleshoot upstream data, process, and system issues that cause invoice rejections or billing errors before they recur.
• Provide input, trend data, and improvement recommendations to enterprise revenue cycle process owners and the Director, Study Operations.
• Collaborate with the Revenue Cycle team, AR and collections staff, and site clinical leadership to resolve billing exceptions, data gaps, and payer disputes in a timely manner.

Patient Billing Support

• Serve as the site coordination and triage point for patient billing inquiries

 

Required Education and Experience:

• Bachelor's degree in Business Administration, Healthcare Administration, Finance, or a related field.
• Minimum 3 years of experience in clinical research operations, healthcare revenue cycle, or a combination of both.
• Working knowledge of clinical trial management systems (OnCore or equivalent CTMS) and familiarity with EDC platforms and financial systems (NetSuite or equivalent ERP).
• Demonstrated ability to identify and resolve data discrepancies across multiple information systems.
• High degree of accuracy and attention to detail; comfort working with data reconciliation.
• Understanding of clinical-to-billing terminology translation: ability to interpret clinical procedure documentation (e.g., EMR language) and align it to billing/budget constructs (e.g., CPT codes, CTMS milestones).

 

Preferred Education and Experience:

• Experience working in Phase I oncology clinical research.
• Familiarity with regulated data environments, including an understanding that changes to clinical records require documented authorization and audit trail; experience working within change control or SOP-governed correction workflows.
• Familiarity with sponsor invoicing and accounts receivable processes in a multi-site research organization.
• Experience with CTMS build, budget overlay, or charge master configuration processes.
• CCRP, CRA, or equivalent clinical research certification.

Best-in-Class Benefits and Perks

We value our employees’ time and efforts. Our commitment to your success is enhanced by a competitive compensation, depending on experience, and an extensive benefits package including:

• Comprehensive health coverage: Medical, dental, and vision insurance provided
• Robust retirement planning: 401(k) plan available with employer matching
• Financial security: Life and disability insurance for added protection
• Flexible financial options: Health savings and flexible spending accounts offered
• Well-being and work-life balance: Paid time off, flexible schedule, and remote work choices provided
• Plus, we work to maintain the best environment for our employees, where people can learn and grow with the company. We strive to provide a collaborative, creative environment where everyone feels encouraged to contribute to our processes, decisions, planning, and culture.

More about The START Center for Cancer Research

Deeply rooted in community oncology centers globally, The START Center for Cancer Research provides access to specialized preclinical and early-phase clinical trials of novel anti-cancer agents. START clinical trial sites have conducted more than a thousand early-phase clinical trials, including for 43 therapies that were approved by the FDA. START represents the world’s largest roster of Principal Investigators (PIs) across its eight clinical trial sites. Committed to accelerating passage from trials to treatments, START delivers hope to patients, families, and physicians around the world.

Learn more at STARTresearch.com.

Ready to be part of a team changing the future of cancer treatment?

Join us in our mission to conquer cancer, one clinical trial at a time. Your expertise and dedication can help us bring hope and healing to patients worldwide. Please submit your application online.

We are an equal opportunity employer that welcomes and encourages diversity in the workplace. We do not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical condition, pregnancy, genetic information, gender, sexual orientation, gender identity or expression, veteran status, or any other status protected under federal, state, or local law.