Associate Director, R&D Chemistry, Peptidomimetics

Associate Director (Peptidomimetics), R&D Chemistry We are currently seeking an established leader and drug hunter to expand Regeneron’s peptidomimetic antibody‑conjugate drug discovery capabilities. The Associate Director will drive discovery across diverse research areas and integrate with the company’s expertise in biologics and novel genetic medicines. Key Responsibilities Directly supervise and manage the day‑to‑day activities of the R&D Chemistry Peptidomimetic group, establishing short‑term and long‑term goals. Communicate Regeneron senior leaders’ priorities, policies, and goals to the team. Drive medicinal‑chemistry‑inspired, SAR‑driven generation of novel peptidomimetic drug modalities using synthetically feasible and simplistically designed linkers to achieve optimal in vitro and in vivo properties of antibody‑conjugated therapeutics. Troubleshoot and optimize peptide potency and stability using standard peptide‑based principles (e.g., Ala scans), non‑natural amino acid incorporation, backbone modifications, and medicinal‑chemistry strategies guided by in vitro assays, plasma/serum stability, and metabolic ID data. Champion and lead the R&D Chemistry Peptidomimetic efforts on internal and external project teams, demonstrating the ability to multi‑task and manage parallel projects to contribute to Regeneron’s development pipeline. Identify new strategies and technologies—linker and payload design—to improve existing Regeneron platforms for peptidomimetic synthesis and bioconjugation. Participate in departmental, cross‑functional, and external meetings to contribute expertise and represent the group’s vision. Interact broadly and collaboratively with other Regeneron groups, forging relationships and active collaborations. Qualifications Ph.D. in peptide, synthetic organic chemistry, or a related field. Minimum of 10years of professional industry experience. Extensive drug discovery experience with antibody‑targeted peptidomimetic drug modalities. Experience with the synthesis and manufacturing of peptidomimetic payloads and linkers. Expertise in modern medicinal‑chemistry structure‑activity relationship (SAR) methods. Deep understanding of biological modes of action (extracellular/intracellular target evaluation, ADME/PK, PD/efficacy, toxicological evaluation). Track record of success in advancing peptidomimetics, small molecules, or antibody‑targeted therapeutics into the clinic and leading teams. Location This is an on‑site position located in our Hawthorne, NY facility. Occasional travel to the nearby Tarrytown facility may be required. Benefits Regeneron offers a competitive and comprehensive total rewards package, which may include annual bonuses, equity awards, pension or retirement benefits, 401(k) company match, health and wellness programs, fitness centers, insurance benefits, paid time off, and family support benefits. For additional information about Regeneron benefits in the U.S., please visit EEO Statement Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, sexual orientation, gender identity or expression, gender reassignment, marital or civil partnership status, civil status, pregnancy or parental status, age, disability, nationality, citizenship status, ethnic or national origin, membership of the Traveler community, familial status, genetic information, military or veteran status, or any other characteristic protected under applicable law. Where required, we will provide reasonable accommodation to applicants with known disabilities or chronic illnesses during the recruitment process, unless such accommodation would impose undue hardship. #J-18808-Ljbffr