Scientist 3, Discovery Oncology

The PositionThe OpportunityWe are seeking a talented and highly motivated Scientist to join our Research Oncology team at Genentech. As a Scientist in this role, you will be critical to delivering on our drug discovery pipeline. You will develop projects and design experiments that yield key mechanistic insights to advance novel therapeutic targets and enable new drug discovery approaches. This position offers the opportunity to collaborate with cross-functional teams and utilize cutting-edge technologies to conduct highly impactful and creative research with the ultimate goal of improving patients’ lives.Key ResponsibilitiesDeliver on the pipeline: Design, execute and interpret hypothesis-driven experiments, generate highly reproducible data robust tools and assays to drive oncology drug discovery forward.Drive scientific discovery: Engage in scientific discussion, stay up to date with the scientific literature in a fast-paced dynamic research environment. Propose new ideas or creative solutions and identify key experiments to yield key mechanistic insights required to pursue and validate therapeutic targets.Collaborate across functions: Work productively with multidisciplinary teams across Genentech, including colleagues in Drug Discovery, Computational Sciences, Translational Medicine, Pathology to support the validation and development of novel therapeutics. Foster a collaborative culture by sharing expertise and learning from others.Communicate findings: Present and discuss data at regular lab meetings, team meetings, department forums, and cross-functional meetings.Who You ArePh.D. in the field of Molecular biology, Cancer Biology, or related fields. Candidates with an M.Sc. and at least 3 years of research experience will also be considered.Possess deep technical expertise in mammalian cell culture (including handling complex or difficult-to-culture models) and advanced cell engineering (CRISPR-Cas9 gene editing, lentiviral/transposon delivery, and generation of inducible or reporter cell lines).Demonstrate hands-on mastery in executing cellular pharmacology and mechanistic assays, such as dose-response viability measurements, pathway modulation assays, Western blotting, qRT-PCR, and protein interaction/pull-down assays.Bring a proven track record of rigorous, impactful research evidenced by peer-reviewed scientific publications, conference presentations, or documented milestone contributions within an industry drug discovery setting.Demonstrate high resilience, self-motivation, and scientific problem-solving capabilities to navigate technical hurdles, with exceptional collaboration skills in team-oriented settings.Preferred experienceStrong background in cancer signaling pathways. Prior work in hormone-dependent cancers would be a plus.Background in transcription factor and chromatin biology, with experience in designing and interpreting NGS experiments (e.g. ATAC-seq, ChIP-seq, RNA-seq). Hands-on proficiency with advanced cellular imaging modalities, including live-cell microscopy, high-content imaging, immunofluorescence (IF), or fluorescence in situ hybridization (FISH) in cell and tissue specimens.Relocation benefits are available for this job posting.The expected salary range for this position based on the primary location of South San Francisco, CA is $103,400 to $192,000. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.BenefitsGenentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.Job SummaryJob number: 202609-123149Date posted : 2026-09-18Profession: Research & DevelopmentEmployment type: Full time