VP Enterprise Architecture and Infrastructure

Job Description:POSITION SUMMARYThe Vice President, Enterprise Architecture & Infrastructure, is responsible for defining and executing TransMedics’ global technology architecture and infrastructure strategy. This leader ensures that the company’s technology foundations, spanning enterprise systems, digital platforms, and operational infrastructure are secure, scalable, and aligned with the company’s rapid growth and global expansion.This role combines strategic architectural vision with hands-on operational leadership, overseeing enterprise architecture, cloud and on-premises infrastructure, IT service delivery, and vendor governance. The VP partners closely with business, manufacturing, and aviation leaders to enable innovation, operational reliability, and disciplined execution. The role requires strong executive presence, the ability to influence across functions and geographies, and a proven track record of leading organizations through transformation.RESPONSIBILITIESEnterprise Architecture LeadershipLead the definition process and own the Enterprise Architecture Vision and Roadmap that aligns technology investments with TransMedics’ business priorities, cost discipline, and global scalability.Establish and maintain an Enterprise Reference Architecture that integrates ERP, Command Center, aviation, digital, and data platforms within secure and efficient architectural frameworks.Lead modernization initiatives leveraging cloud-native services, APIs, automation, and microservices to enable agility and performance.Collaborate with business and functional leaders to translate strategic objectives into actionable architecture blueprints.Drive architectural consistency and standardization across multi-cloud and on-premises environments.Partner with the cybersecurity and compliance teams to ensure all designs adhere to information security and regulatory requirements.Infrastructure & Cloud OperationsLead and manage the 24x7 Global Service Desk and infrastructure operations teams to deliver superior uptime, reliability, and user experience.Ensure 99.999% uptime for critical business systems, including the Command Center and manufacturing systems.Oversee the design, deployment, monitoring, and maintenance of all cloud and on-premises infrastructure, ensuring performance, scalability, and security.Implement and maintain observability and monitoring frameworks for proactive system reliability and performance management.Drive continuous improvement in service delivery, automation, and cost efficiency through data-driven operational reviews.Establish key operational KPIs (e.g., system uptime, ticket resolution time, cloud cost efficiency) and report performance transparently to leadership.Stakeholder Engagement & CommunicationServe as a strategic advisor to the CIO and senior leadership on architecture and infrastructure priorities.Communicate complex technical strategies and trade-offs clearly to non-technical audiences, including executives and board-level stakeholders.Partner with regional and functional leaders (manufacturing, aviation, logistics, and digital) to ensure alignment between IT capabilities and operational objectivesGovernance, Vendor & Financial ManagementDevelop and manage the infrastructure and architecture budget, ensuring optimal resource allocation and financial discipline.Oversee vendor selection and performance management, ensuring strategic alignment, service excellence, and cost-effectiveness.Lead due diligence and integration efforts for technology platforms during acquisitions and global expansion initiatives.Define and enforce standards and policies for change management, infrastructure operations, and technology lifecycle management.Leadership and People ManagementLead and inspire a global team of architects and infrastructure professionals, promoting a culture of accountability, innovation, and excellence.Mentor and develop next-generation leaders across the IT organization.Foster strong collaboration across IT, finance, operations, and digital functions.Model TransMedics’ core values: integrity, discipline, transparency, and teamwork.Management ResponsibilitiesThis position manages the following positions on a daily basis:Sr Manager, Cloud Infrastructure & OperationsInfrastructure ArchitectApplication ArchitectPhysical AttributesNone (standard work environment) Minimum Qualifications 15+ years of IT leadership experience, including 5+ years in enterprise architecture and cloud infrastructure at the executive level.Proven success leading global 24x7 SaaS/Cloud operations and large-scale data center environments.Demonstrated experience implementing highly available, scalable, and secure enterprise systems across hybrid (cloud/on-premises) environments.Expertise in cloud platforms such as Azure, AWS, or Google Cloud, and modern infrastructure management tools.Strong financial acumen and experience managing multimillion-dollar technology budgets.Excellent communication, executive presence, and ability to influence across all organizational levels.Bachelor’s degree in information systems, computer science, or related discipline required; MBA or advanced degree preferred. years’ experience in senior IT leadership roles, with a focus on enterprise architecture and cloud infrastructure.Preferred QualificationsExperience leading large-scale digital or enterprise transformation initiatives within global, fast-scaling organizations.Familiarity with enterprise architecture frameworks such as TOGAF or Zachman.Experience supporting manufacturing or medical device operations with regulated systems.Strong understanding of cybersecurity integration, data governance, and business continuity planning.Every Organ Wasted is a Life Not Saved.TransMedics, Inc. is a commercial-stage medical technology company transforming organ transplant therapy for patients worldwide. Our mission is to help save more patients’ lives by increasing access to viable donor organs for those who are awaiting an organ transplant. To accomplish this mission, we partner closely with transplant stakeholders worldwide and help expand their access to healthy donor organs, while delivering the highest quality technology, service, clinical care and outcomes. Driven by a passion for improving patient care, we make the impossible possible and keep our employees at the center of everything we do. Together, we strive to enhance the quality of life for transplant recipients and their families, fostering hope and healing in the journey toward better health. Maximize your potential at TransMedics, Inc. TransMedics is committed to equitable and transparent compensation. The expected base salary range for this role is $295,800.00-$369,000.00, which represents the company’s current good-faith estimate of compensation for this position. Actual salary will depend on factors such as, but not limited to, candidate experience, qualifications, skills, and the specific work location. This role may also be eligible for bonuses, equity, and a comprehensive benefits package (medical, dental, vision, retirement savings, paid time off, and wellness resources). We comply with all U.S. pay transparency laws and do not request or consider salary history.Employee Benefit:Medical with Health Reimbursement Account through Blue Cross/Blue Shield of MADentalVision Healthcare Flexible Spending AccountDependent Care Flexible Spending AccountShort Term DisabilityLong Term Disability401K PlanPet insurance Employee Stock Purchase PlanTransMedics is an equal opportunity employer and does not discriminate on the basis of race, color, religion, sex, national origin, marital status, age, disability or protected veteran status, or any other characteristic protected by law. We are committed to creating an inclusive environment for all employees.SummaryLocation: Andover, MAType: Full time