Scientist - Disease Biology Discovery Research

Join Amgen’s Mission of Serving Patients At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. Amgen is advancing a broad and deep pipeline and portfolio of medicines to treat heart disease, obesity and obesity-related conditions, rare diseases, inflammatory conditions and cancer. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career. Scientist – Disease Biology Discovery Research What You Will Do Let’s do this. Let’s change the world. In this vital role you will commit to developing a deep understanding of disease biology, identify novel drug targets in the non-oncology space, and play a pivotal role in advancing our pre-clinical pipeline. This position is within the Cardiometabolic Disorders Department of Amgen Research in South San Francisco. You will join a team of dedicated scientists committed to finding treatments for a diverse set of disease indications, including but not limited to cardiac, cardiovascular, fibrotic, and renal diseases. To be successful in this role, you will need to have great molecular and cell biology laboratory skills, deep scientific curiosity, and strong interpersonal and communication skills to thrive in a collaborative environment. This is a permanent role that offers opportunities for advancement and career development. If you have a passion for science and want to be part of an organization discovering new medicines that will impact patients’ lives, we invite you to join us! Key Responsibilities Work collaboratively with a team of experts to generate robust data to support the preclinical validation of novel therapeutic targets and to advance the understanding of disease biology. Independently design and execute in vitro and ex vivo mechanism-of-action experiments, including troubleshooting, assay optimization, and data collection, analysis, and interpretation. Present research findings effectively in both written and oral formats for internal teams and external collaborators. Participating in cross-functional drug development teams as a key intellectual and technical contributor What We Expect Of You We are all different, yet we all use our unique contributions to serve patients. The dedicated professional we seek is a highly motivated laboratory scientist with these qualifications. Basic Qualifications Doctorate degree PhD OR Master’s degree and 2 years of Molecular and Cell Biology experience OR Bachelor’s degree and 4 years of Molecular and Cell Biology experience Preferred Qualifications Extensive experience in cell-based, molecular and biochemical techniques, including RNA isolation/qPCR, protein immunoprecipitation, immunoblotting, ELISA, flow cytometry, and cell imaging and image processing. Extensive experience in performing in vitro and cellular assays to dissect the function of genes of interest or the mechanism of action of therapeutic molecules as demonstrated by high-impact publications. Strong interpersonal and organizational skills, a high level of accuracy, commitment to record keeping, and attention to details. undefined Expertise with cell line engineering technologies, including CRISPR and virus-based stable cell line generation is preferred Demonstrated experience analyzing and interpreting complex datasets. Expertise with human iPSCs, especially iPSC-derived cardiomyocytes, is preferred What you can expect from us As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way. The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications. Benefits A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan Stock-based long-term incentives Award-winning time-off plans Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies. In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information. Application deadline Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position. Sponsorship Sponsorship for this role is not guaranteed. As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease. Amgen is an Equal Opportunity employer. We make all employment decisions without regard to race, color, religion, sex or any other characteristic protected by applicable law. We provide reasonable accommodations to applicants and employees with disabilities, consistent with legal requirements. Please contact us to request accommodation. #J-18808-Ljbffr Amgen