Principal Scientist - PKDM, Modeling and Simulation

Career Category: Scientific Position Title Principal Scientist‑PKDM, Modeling and Simulation What you will do In this vital role you will contribute to Amgen’s diverse discovery and development portfolio of therapeutic modalities with a focus on understanding the pharmacokinetics and pharmacodynamic properties of small and large molecule drug candidates being developed across multiple therapeutic areas in Amgen’s pipeline. This role is responsible for supporting PKPD‑related and mathematical modeling activities in the PKDM space for drug discovery and development. You will work directly with other PKDM stakeholders to apply quantitative solutions in the development of novel therapeutics through various activities including target/compound evaluation, design of preclinical studies, investigation of exposure‑response relationships, execution of translational strategies, and influencing clinical study design. Key Responsibilities Devise and implement quantitative analysis and strategies to inform decision making in drug development by using mathematical modeling and quantitative pharmacology principles with a focus on mechanistic and translational modeling. Collaborate with project team representatives within PKDM and multi‑disciplinary teams to generate key knowledge to inform these quantitative strategies. Conduct hands‑on work on fit‑for‑purpose mathematical models (PK‑PD, QSP, PBPK) using specialized relevant modeling tools. Apply AI‑ML strategies to modernize traditional PK‑PD modeling strategies. Document and archive contributions including data analyses, mathematical models, summary presentations and reports to be shareable with other scientists and foster a collaborative environment. Summarize and articulate salient findings, communicate conclusions back to project team representatives and cross‑functional teams and actively participate in team discussions supporting decision making in drug development. Build effective collaborations with peers and stakeholders within and outside the PKDM department including chemistry, biology, toxicology, biomarkers and protein scientists. Basic Qualifications Doctorate degree PhD OR PharmD OR MD and 2 years of experience applying quantitative PKPD principles to drug development or other relevant experience. Master’s degree and 5 years of experience applying quantitative PKPD principles to drug development or other relevant experience. Bachelor’s degree and 7 years of experience applying quantitative PKPD principles to drug development or other relevant experience. Preferred Qualifications Doctorate (Ph.D.) in chemical or biomedical engineering; applied mathematics; quantitative pharmaceutical sciences or a related field with 2+ years of experience in drug discovery and development. Proven record of applying systems modeling and simulation approaches in biological systems and/or drug development to support strategic decision making. Proficiency with systems modeling approaches such as differential equations, nonlinear mixed effects modeling, logic, stochastic, agent‑based, or other advanced mechanistic modeling approaches is essential. Hands‑on experience with relevant software or programming languages (e.g., R, Simbiology, MATLAB, R, or C) is essential. Critical thinking and demonstrated ability to communicate with team members across broad disciplines. Highly motivated, self‑driven, can perform well both working independently and in team settings. High degree of flexibility with ability to adapt to different projects and teams. Excellent oral and written communication skills. Benefits and Compensation Salary range: $163,670.05 – $221,435.95 (USD) per annum. Amgen offers a Total Rewards Plan comprising health and welfare plans, financial plans, work/life balance, and career development opportunities. A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental, and vision coverage, life and disability insurance, and flexible spending accounts. A discretionary annual bonus program, or for field sales representatives, a sales‑based incentive plan. Stock‑based long‑term incentives. Award‑winning time‑off plans. Flexible work models where possible. Equal Opportunity Employer Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance. #J-18808-Ljbffr