Principal Scientist
$276.1k - $350kAmazon
Description This is a Sr. Principal Applied Scientist role within the Advertising Full Funnel Agentic Intelligence and Models team, designed to drive foundational model innovation for Amazon Ads. The team is building next-generation agentic AI systems for advertising. This hire will serve as a key technical leader bringing rare low-level model development expertise to Amazon Ads. This is a high-visibility, high-impact role requiring deep expertise in multimodal foundation models, model architectures, and training methodologies at scale. Key job responsibilities Define long-term scientific vision for advertising technologies, translating complex customer needs into strategic roadmaps Design and implement innovative machine learning and generative AI solutions across multiple advertising product domains Mentor and develop scientific talent, fostering a culture of excellence and continuous innovation Collaborate with senior leadership to influence technical direction and strategic decision-making Establish partnerships with academic institutions to drive cutting-edge research and talent development Basic Qualifications Doctoral degree in Computer Science, Machine Learning, Artificial Intelligence, or related technical discipline Extensive expertise in machine learning, generative AI, and large language model technologies Proven track record of translating advanced research into production-ready solutions Strong publication record in peer-reviewed conferences and journals Demonstrated ability to communicate complex technical concepts to diverse audiences Preferred Qualifications Experience in advertising technology, recommendation systems, or e-commerce platforms Expertise in multi-modal AI systems and advanced natural language processing Background in developing scalable machine learning infrastructure Experience leading cross-functional scientific research initiatives Demonstrated ability to mentor and develop scientific talent Amazon is an equal opportunity employer and does not discriminate on the basis of protected veteran status, disability, or other legally protected status. Los Angeles County applicants: Job duties for this position include: work safely and cooperatively with other employees, supervisors, and staff; adhere to standards of excellence despite stressful conditions; communicate effectively and respectfully with employees, supervisors, and staff to ensure exceptional customer service; and follow all federal, state, and local laws and Company policies. Criminal history may have a direct, adverse, and negative relationship with some of the material job duties of this position. These include the duties and responsibilities listed above, as well as the abilities to adhere to company policies, exercise sound judgment, effectively manage stress and work safely and respectfully with others, exhibit trustworthiness and professionalism, and safeguard business operations and the Company’s reputation. Pursuant to the Los Angeles County Fair Chance Ordinance, we will consider for employment qualified applicants with arrest and conviction records. Our inclusive culture empowers Amazonians to deliver the best results for our customers. If you have a disability and need a workplace accommodation or adjustment during the application and hiring process, including support for the interview or onboarding process, please visit for more information. If the country/region you’re applying in isn’t listed, please contact your Recruiting Partner. Amazon also offers comprehensive benefits including health insurance (medical, dental, vision, prescription, Basic Life & AD&D insurance and option for Supplemental life plans, EAP, Mental Health Support, Medical Advice Line, Flexible Spending Accounts, Adoption and Surrogacy Reimbursement coverage) 401(k) matching paid time off parental leave Learn more about our benefits at . USA, CA, Palo Alto - 276,100.00 - 350,000.00 USD annually USA, WA, SEATTLE - 240,100.00 - 324,800.00 USD annually #J-18808-Ljbffr
$276.1k - $350k
...Description This is a Sr. Principal Applied Scientist role within the Advertising Full Funnel Agentic Intelligence and Models team, designed to drive foundational model innovation for Amazon Ads. The team is building next-generation agentic AI systems for advertising....PrincipalLocal areaFlexible hours$225k - $275k
...Principal Scientist ID 2025-2214 Location US-CA-Menlo Park Practice Polymers and Chemistry Position Type Full-time Posted Salary Range USD $225,000.00 - USD $275,000.00 /Yr. About Exponent Exponent is the only...PrincipalFull timeWork at officeFlexible hours$307k - $428k
...guardrails protect against genuine misuse without bottlenecking legitimate scientific innovation. Partner closely with Research Scientists, Engineers, and ethics experts to embed biosecurity protocols directly into the model development lifecycle. Refine and directly...Principal$240.1k
Description We are looking for a senior AI/ML researcher who can architect and guide a long-horizon ML strategy for a healthcare-focused organization building a durable, domain-specific healthcare foundation model and a high-reliability inference system. This person will...PrincipalLocal area$185k - $215k
...pay range $185,000.00/yr - $215,000.00/yr **Posting for our client, Isotovia Biosciences ** We are looking for an outstanding Principal Scientist to join our Discovery team at Isotovia Biosciences, a new company in San Carlos. This individual will be a part of an...PrincipalFull time$195.67k - $253.22k
...confronting the largest public health challenges of our day and improving the lives of patients for generations to come. As a Principal Scientist, Analytical Operations at Gilead you will act as the Quality Control (QC) Lead and will be responsible for the strategic...PrincipalContract workFor contractorsLocal area$126k - $248k
...models with MongoDB's data platform to create powerful end-to-end solutions. POSITION OVERVIEW We are seeking a Senior Research Scientist to join our team and contribute to the development of next-generation AI models. This position offers a unique opportunity to...Full timeLocal areaWorldwideFlexible hours$200k - $245k
...suffer from genetic diseases. Located on the Stanford Life Sciences campus, GondolaBio fosters a unique hybrid environment where top scientists from around the world collaborate with senior leadership and advisors, blending industry expertise with academic innovation....PrincipalFlexible hours- Amazon.com Services LLC in Palo Alto is seeking a professional to design, train, and optimize AI models for product image generation. The role entails developing systems that connect AI-generated visuals with a vast product catalog, ensuring high quality and relevance ...
$200k - $300k
...A leading financial technology firm in California is looking for AI Research Scientists and Engineers to advance their AI capabilities. You will focus on post-training SOTA LLMs and work with multiple specialized teams. Applicants should have experience in large-scale...- ...MLE, GPU kernel, backend infrastructure, product, and customer teams to choose high-leverage research bets. Mentor engineers and scientists on experimental design, scientific rigor, and model/system tradeoffs. Must-haves PhD in computer science, machine learning, ML systems...
- DELFI Diagnostics in Palo Alto, California, is seeking a Senior Technical Leader for the bioinformatics pipeline team. This role involves setting technical strategy, leading system architecture design, and mentoring engineers while collaborating across various departments...Flexible hours
$192.2k - $260k
...Senior Applied Scientist, Sponsored Products and Brands -- Offsite Job ID: 10458147 | Amazon.com Services LLC The Sponsored Products and Brands (SPB) team at Amazon Ads is re‑imagining the advertising landscape through industry‑leading generative AI technologies. The team...Flexible hours- ...-to-end solutions. Contribute to improving our engineering processes, tooling, and standards. What We’re Looking For Our ideal Principal Software Engineer will have: Strong passion for making developers highly productive. 12+ years industry experience developing tools...PrincipalFull time
$192.2k - $260k
...Sr. Applied Scientist, AWS Just-Walk-Out Science Team Job ID: 10428547 | Amazon.com Services LLC As part of the AWS Solutions organization, we have a vision to provide business applications, leveraging Amazon’s unique experience and expertise, that are used by millions...Local areaWorldwideFlexible hours$180k - $258.75k
...newest technologies into practice, both within Toyota and the open research community. THE OPPORTUNITY We are hiring a Senior Research Scientist to help deepen the chemistry at the core of our materials-design models. This is a full-time role with the scope to take problems...Full timeLocal areaShift work$143.63k - $299.38k
Yahoo Mail is the ultimate consumer inbox with hundreds of millions of users. It's the best way to access your email and stay organized from a computer, phone or tablet. With its beautiful design and lightning fast speed, Yahoo Mail makes reading, organizing, and sending...Work at officeFlexible hours- EY EDGE is a leader in providing dedicated tax technical services to US and global clients. This role within EY EDGE focuses on complex tax projects, regulatory reviews, and advisory services to build trusted client relationships and deliver high-quality solutions. You ...
$180k - $200k
...A high-functioning family office in Atherton, CA is seeking an Executive Assistant to support their Principal. The ideal candidate is adaptable, with at least 5 years of experience in a similar role. Responsibilities include managing a dynamic calendar, coordinating travel...PrincipalFull timeWork at office- ...Cambridge, MA, driven by scientific rigor, translational urgency, and a patient-anchored mandate. The Institute is seeking a Principal Scientist, Cell Modeling to lead the design, generation, and characterization of the human cell systems that underpin its therapeutic...PrincipalContract work
$208k - $280k
...Intuit is seeking a Principal Service Experience Strategy – Mid Market in Mountain View, California. This role focuses on creating and optimizing product-led services that enhance customer experiences. The ideal candidate will have 8–10 years of experience in customer...Principal- ...intellectual integrity, service ownership, and creative impact. Role Description: We are looking for an experienced, hands-on antibody scientist with deep expertise in antibody discovery, characterization, and antibody drug conjugate (ADC) development to join our team. In...PrincipalFull time
- ...chemistry to identify and advance drug candidates with a structural edge over conventional approaches. We are looking for a Senior Scientist to become a cornerstone of our wet lab operations. You will own key areas of our experimental platform — from cell culture and...
- ...Job Description Job Description Job Title : Principal Applications Scientist – Mass Spectrometry Location : Milpitas, California, USA Industry : Manufacturing/Industrial/Production/Machinery Salary : To Be Discussed Required Citizenship / Work Permit...PrincipalWork experience placementWork visa
- A startup incubator is looking for a DeepTech Co-Founder / CPO to lead their own startup with potential funding of up to €500k. This role includes owning the startup journey, extensive personal development support from successful entrepreneurs, and access to a network of...PrincipalRemote work
- MAJOR DUTIES AND RESPONSIBILITIES Responsibilities will include, but not be limited to: Initiate, direct, and execute all scientific research and/or development strategies in research and/or development Investigate the feasibility of applying a wide variety of...Principal
- ...Analytical Development (AD) and Quality Control (QC) as it advances from Phase I toward Phase II development. As the primary AD/QC scientist for our small molecule program, you will lead the analytical strategy for drug substance and drug product, working closely with...PrincipalFlexible hours
$85k - $100k
Senior Analytical Scientist Location: Menlo Park, CA Pay Rate: $85,000-100,000 Advance Peptide Discovery with Cutting-Edge Mass Spectrometry Staffmark is seeking an experienced Senior Analytical Scientist for a consulting opportunity supporting an innovative peptide...For contractorsLocal area$195.67k - $253.22k
...confronting the largest public health challenges of our day and improving the lives of patients for generations to come. As an Principal Scientist, Analytical Lifecycle Management , you will serve as the Quality Control lead for late-stage biologics programs, acting as...PrincipalFull timeContract workFor contractorsLocal area$112k - $168k
## Scientist II, Field Applications Bioinformatics SupportApplylocations: US - California - Menlo Parktime type: Full timeposted on: Posted Yesterdayjob requisition id: JR100857Scientist II, Field Applications Bioinformatics Support PacBio (NASDAQ: PACB) is a premier life...Work at officeHome office
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