Technical Project Manager

Company Description

Guardant Health is a leading precision oncology company focused on guarding wellness and giving every person more time free from cancer. Founded in 2012, Guardant® is transforming patient care and accelerating new cancer therapies by providing critical insights into what drives disease through its advanced blood and tissue tests, real-world data and AI analytics. Guardant tests help improve outcomes across all stages of care, including screening to find cancer early, monitoring for recurrence in early-stage cancer, and treatment selection for patients with advanced cancer. For more information, visit guardanthealth.com and follow the company on LinkedIn, X (Twitter) and Facebook.


We are seeking an experienced Technical Project Manager (based out of our Palo Alto, CA office) to lead the development, release, and delivery of EMR/EHR integration solutions that connect our precision oncology platforms to healthcare provider systems. In this pivotal role, you will enable oncologists and care teams to receive real-time, actionable genomic insights within their existing clinical workflows. You'll drive agile execution, coordinate complex interoperability projects, and ensure every integration meets the highest standards of accuracy, compliance, and security. You will collaborate closely with engineering, product, bioinformatics, security, compliance, and external healthcare partners to enhance data interoperability between precision oncology systems and EHR platforms such as Epic, Cerner, Athenahealth, and Allscripts.

Agile Delivery & Scrum Leadership

• Lead agile teams developing APIs, integration middleware, and FHIR-based data services connecting oncology software to EMR/EHR systems.
• Facilitate all scrum ceremonies (sprint planning, stand-ups, reviews, retrospectives), ensuring strong alignment between technical deliverables and clinical data requirements.
• Coach teams on Agile practice to improve delivery predictability and quality. Ensure integration features meet healthcare compliance standards (HIPAA, HITRUST, FDA 21 CFR Part 11).
• Collaborate with Product Owners, integration engineers, and healthcare IT stakeholders to define and prioritize integration backlogs.

Release Management

• Own the release lifecycle for EMR/EHR integrations - from planning and validation to deployment and monitoring.
• Coordinate cross-functional testing with QA, Clinical Operations, and external EHR vendors.
• Maintain integration release calendars, regression plans, and change management documentation.
• Communicate release scope, timelines, and risks to stakeholders across engineering, compliance, and partner organizations.

Technical Project Management

• Manage technical projects that support bi-directional integration between oncology diagnostic systems and provider EHRs.
• Define scope, milestones, and success metrics for data exchange initiatives (lab results delivery, order entry, patient matching).
• Partner with internal and external teams to design scalable, secure, and standards-compliant interfaces.
• Oversee development and deployment of APIs and microservices supporting interoperability with major EMR/EHR vendors.
• Ensure documentation and validation artifacts support audit and regulatory readiness.
• Utilize JIRA, Confluence, and similar tools to manage technical tasks, track dependencies, and report progress.

Required Qualifications

• Bachelor's degree in computer science, Information Systems, Engineering, or related field.
• 8+ years of experience in software delivery, technical project management, or release management within healthcare IT or diagnostics.
• Proven track record leading Agile teams delivering EMR/EHR integration or healthcare interoperability solutions.
• Understanding of EHR systems such as Epic, Cerner, Athenahealth, or Allscripts and their integration frameworks.
• Familiarity with cloud-based architecture (AWS, GCP) and CI/CD pipelines for healthcare applications.
• Strong communication and stakeholder management skills across technical and clinical domains.
• Exceptional organizational skills and attention to detail, particularly around data integrity and compliance documentation.
• Proactive communicator comfortable managing cross-functional and vendor-facing relationships.
• Adaptable and calm under pressure when managing multiple releases and dependencies.

Preferred Qualifications

• Certified Scrum Master (CSM), SAFe Agilist, or PMP certification.
• Experience in oncology, genomics, or diagnostic data systems.
• Familiarity with SMART on FHIR apps, and healthcare API gateway management. Knowledge of regulatory standards such as HIPAA, HITRUST, CLIA, CAP, and FDA 21 CFR Part 11.
• Experience with validated software processes under a Quality Management System (QMS).
• Exposure to laboratory information systems (LIS/LIMS) and clinical order/result workflows.

AI & Digital Fluency

• Demonstrate curiosity, sound judgment, and the ability to critically evaluate and responsibly leverage AI-enabled tools in accordance with company policies, ethical standards, and regulatory requirements to improve the efficiency, effectiveness, and quality of work.

Hybrid Work Model: This section is applicable to onsite employees who are eligible for hybrid work location as specified by management and related policies. Guardant has defined days for in-person/onsite collaboration and work-from-home days for individual-focused time. All U.S. employees who live within 50 miles of a Guardant facility will be required to be onsite on Mondays, Tuesdays, and Thursdays. We have found aligning our scheduled in-office days allows our teams to do the best work and creates the focused thinking time our innovative work requires. At Guardant, our work model has created flexibility for better work-life balance while keeping teams connected to advance our science for our patients.


The annualized base salary ranges for the primary location and any additional locations are listed below. This range does not include benefits or, if applicable, bonus, commission, or equity. Each candidate's compensation offer will be based on multiple factors including, but not limited to, geography, experience, education, job-related skills, job duties, and business need.Primary Location: Palo Alto, CAPrimary Location Base Pay Range: $155,800 - $214,250Other US Location(s) Base Pay Range: $132,430 - $182,113If the role is performed in Colorado, the pay range for this job is: $140,220 - $192,825

Employee may be required to lift routine office supplies and use office equipment. Majority of the work is performed in a desk/office environment; however, there may be exposure to high noise levels, fumes, and biohazard material in the laboratory environment. Ability to sit for extended periods of time.

Guardant Health is committed to providing reasonable accommodations in our hiring processes for candidates with disabilities, long-term conditions, mental health conditions, or sincerely held religious beliefs. If you need support, please reach out to View email address on click.appcast.io

A background screening including criminal history is required for this role. GH will consider qualified applicants with criminal arrest or conviction histories in a manner consistent with applicable law including but not limited to the LA County Fair Chance Policies and the Fair Chance Act (Gov. Code Section 12952).

Guardant Health is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

All your information will be kept confidential according to EEO guidelines.

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