Chemist II - Oligo Plate Synthesis

Overview:

Business Title: Chemist II - Oligo Plate Synthesis

Position Title: Analyst II

Division: Consumer Products Services

Entity: Consumer Products Services/ATL

Location: Boston, MA

Reports to: Manager

FLSA: Non-exempt

Hours Worked:Typically, Monday through Friday, forty-hours per week. However, must be flexible to meet the needs of the department and complete other projects as assigned.

Position Summary:

The Chemist II is responsible for the synthesis and downstream processing of plate-based oligonucleotides. The chemist will be responsible for maintaining synthesizers, executing the synthesis, analyzing products via LC-MS, formulating the oligos for delivery to biologists on a liquid handler, and performing QC checks on the final delivery plates. This person will work on multiple projects simultaneously and stay current with new modifications of oligonucleotides.

Duties and Responsibilities:

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• Synthesis : Assist in the synthesis of oligonucleotides using automated 786 synthesizers, following established protocols, ensuring accuracy in reagent preparation and reaction conditions.
• Purification : Perform purification of oligonucleotides, if needed, using techniques such as FPLC or cartridge-based purification.
• Analysis: Conduct analytical assays including LCMS to verify the quality and identity of synthesized oligonucleotides
• Documentation : Maintain accurate and detailed records of experiments, procedures, and results using ELNs. Ensure all documentation is compliant with company standards and regulatory requirements.
• Lab Maintenance : Contribute to the maintenance of the laboratory.
• Collaboration : Work closely with senior chemists and other team members to support ongoing projects.
• Use of general laboratory equipment including but not limited to pipettors, nanodrops, centrifuges, and balances
• Software includes instrument-specific for capturing and analyzing data, Microsoft Office (Word, Excel, PowerPoint, Outlook, Teams/Sharepoint, etc), LIMS, electronic laboratory notebooks, etc.
• Identify, troubleshoot, and suggest technical solutions to clients and management

• Follow the guidelines set forth with clients and Company Quality, Health, Safety, Security and Environmental policies and procedures.
• Comply with clients' and Company management systems in accordance with appropriate regulatory agencies.
• Other duties as defined by the Manager, department needs and workload

Skills & Proficiencies:

• Strong laboratory skills and, as well as basic laboratory techniques and equipment (pipetting, mass spectrometry, chromatography) is required
• Basic understanding of chemistry, stoichiometry and chemical synthesis
• Hands on experience in solid phase oligonucleotide synthesis is a plus
• Experience with analytical instrumentation such as Agilent LC-MS and UPLC, Vanquish LTQ is a plus
• Strong organizational skills and time management skills
• Effective communication skills for collaborating with team members and conveying technical information clearly.
• Strong problem-solving abilities and critical thinking skills

• Ability to organize and prioritize workload to meet or exceed deadlines
• Individual and Team work ethic
• Proficiency with Windows, Word & Excel
• Strong attention to detail and ability to follow protocols precisely
• Positive attitude, self-motivated, high level of engagement
• Eagerness to learn and adapt in a fast-paced environment
• Champions and adheres to company values including team engagement

Education and Experience:

• Degree requirement: Bachelor's Degree in Chemistry, Chemical/Biomedical engineering, pharmaceutical sciences or a related field with 1-2 years experience or Master's degree with 0-1 year experience.

Compensation Range: $36.00-$40.00 per hour (e.g., the job posting is not necessarily reflective of actual compensation that may be earned, and actual compensation is subject to variation due to such factors as location, education, experience, and skillset).

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