Principal Scientist Biophysical Characterization

At Lilly, we unite caring with discovery to make life better for people around the world. Our global healthcare organization is headquartered in Indianapolis, Indiana and is committed to bringing life‑changing medicines to patients, improving disease understanding and management, and giving back to communities. Verve Therapeutics, a wholly owned subsidiary of Eli Lilly & Company within Lilly Research Labs, is a clinical‑stage genetic medicines company focused on transforming cardiovascular disease treatment through gene editing. The Analytical Development Group at Verve consists of analytical chemists, molecule biologists, and pharmaceutical scientists who develop and refine analytical methods for LNP‑gene therapy systems. Responsibilities Develop, optimize, and execute analytical methods for release, stability, product characterization, and high‑throughput analysis of raw materials, RNA drug substances, and LNP products. Collect, process, and analyze experimental data using HPLC, UHPLC, capillary electrophoresis, LCMS, MALS, and related techniques; maintain accurate documentation in the electronic laboratory notebook. Review, interpret, and present analytical data to the team and cross‑functional partners. Author, review, and revise technical source documents to support phase‑appropriate comparability. Provide technical oversight to guide analytical/QC investigations and collaborate with internal and external development and quality teams. Train and mentor junior team members. Qualifications MS in analytical chemistry, biochemistry, biophysics, or a related field with 4+ years of experience in the biotech or biopharmaceutical industry, OR BS with 6+ years of experience. Minimum 3 years of experience in LC and CE assay development. Hands‑on experience developing, qualifying, and troubleshooting biophysical assays using HPLC/UPLC, LCMS, and CE. Must be authorized to work in the United States on a full‑time basis; Lilly does not sponsor work authorization or visas. Preferred Qualifications Strong background in analytical methodologies using CE and HPLC for gRNA, mRNA, and LNPs. Experience in method transfer, validation, and implementation across non‑GxP to GMP environments. Familiarity with advanced characterization instrumentation such as cryo‑TEM, NMR, FFF‑MALS, DLS, NTA, DSC, and AUC. Knowledge of ICH regulations related to method validation. Proactive, creative, and positive attitude with effective oral and written communication skills. Actual compensation will depend on education, experience, skills, and geographic location. The anticipated wage range for this position is $71,250 – $187,000. Full‑time employees may also be eligible for a company bonus, a 401(k) plan, pension, vacation benefits, medical, dental, vision, prescription drug benefits, flexible benefits, life and death insurance, leave of absence benefits, and well‑being benefits. Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce. If you require accommodation to submit a resume, please complete the accommodation request form (careers.lilly.com/us/en/workplace-accommodation) for further assistance. Lilly is proud to be an EEO employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status. #J-18808-Ljbffr 100 Eli Lilly and Company