Oligonucleotide Biology Scientist — In Vitro & Cell Models
$147k - $191kDenali Therapeutics Inc
Denali Therapeutics Inc in South San Francisco seeks a skilled individual to develop and validate HT oligo-based in-vitro screening assays for drug discovery. In this role, you will collaborate extensively with scientists to enhance targeted therapies for neurodegenerative diseases. We require a Ph.D. or comparable experience in molecular or cell biology, alongside strong skills in oligonucleotide activity screening. Salary ranges from $147,000 to $191,000, supplemented with comprehensive benefits. #J-18808-Ljbffr Denali Therapeutics Inc
$147k - $191k
...commitment to degeneration biology and principles of... ...of leading scientists, industry experts,... ...HT oligo-based in-vitro screening assays... ...Develop advanced cell-based screening techniques... ..., iPSC-derived models, ex vivo systems,... ...of superior oligonucleotide therapeutics at Denali...SuggestedContract workLocal area$156k - $176k
...laboratories for our cell machine learning... ...molecules to oligonucleotides. We are seeking... ...highly motivated scientist to support our growing... ...and execute in vitro and in vivo... ...molecular and cellular biology experiments to... ...predictive therapeutic modeling Integrate target...SuggestedHome officeFlexible hours3 days per week- ...robust oligo-based screening assays for drug discovery. Ideal candidates should have a Ph.D. in molecular or cell biology and a deep understanding of oligonucleotide-based activity screening techniques. The role requires strong leadership, teamwork, and the ability to...Suggested
- ...(SGA), is searching for a Scientist, Complex in Vitro Systems (Lung Focus) for a... ...advanced complex in vitro models to support the firm's mission... ...models, including evaluation of cell viability, morphology, and... ...in Bioengineering, Cell Biology, Molecular Biology,...SuggestedContract work
$131.4k - $206.8k
...Francisco is seeking a Senior Scientist to join our discovery... ...and applying robust cell-based and ex-vivo... ...understanding of disease biology and mechanism of action... ...excels at integrating in vitro findings with preclinical... ...(including 2D and 3D models) in cardiac or vascular...SuggestedFor contractorsLocal areaRelocationVisa sponsorshipFlexible hoursShift work- ...Description Overview: The Biologics CMC Development organization... ...eventual licensure. The Cell Line Development (CLD)... ...Innovation Group is seeking a Senior Scientist I to join a talented and... ...in/out target genes, and in vitro transcription. Receive externally...Temporary workLocal area
$104.7k - $194.4k
...work at the cutting edge of cell therapy. The work you do here... ...batch‑to‑batch consistency and biological identity of differentiated... ...reflective assays to demonstrate in vitro biological function of... ...troubleshooting these instruments. The "Scientist-as-Architect" Mindset: A...Local areaRelocation package$165k - $215k
...the mission of bridging biological and artificial... ...validates their performance in vitro and in vivo, and demonstrates... ...capabilities in animal models. We build custom... ...with engineers and data scientists. We work across disciplines... ...Role As a Scientist in Cell Biology, you will...Full time$124.3k - $230.9k
...people we love. The Department of Cell and Tissue Genomics (CTG) is... ...key challenges in disease biology, target discovery, and translational... ...(e.g., embeddings, foundation models) is a plus. Comfortable with... ...of California for Senior Scientist is $124,300- $230,900 and Principal...Local areaRelocation package- ...life sciences, is looking for a “ Scientist (Complex In Vitro Systems - Lung Biology)" based out in South San Francisco... ...of advanced human lung in vitro models for translational safety and drug... ...Requirements: PhD in Bioengineering, Cell Biology, Molecular Biology,...Long term contractContract work
$106k - $138k
...Design, synthesize, purify, and characterize oligonucleotide therapeutics, including siRNA/ASOs, for... ...and bioconjugates. Interpret in vitro and in vivo data to generate structure-activity... ...with cross-functional teams (Biology, Protein Sciences, DMPK, and related functions...$106k - $138k
...commitment to degeneration biology and principles of translational... ...collaboration of leading scientists, industry experts, and investors... .... This role will apply oligonucleotide chemistry and bioconjugation... ...bioconjugates. Interpret in‑vitro and in‑vivo experimental data...Local area- ...Genentech is seeking a Scientist 3 to join the Synthetic... ...immune engager and CAR-T cell therapy programs. This... ...to explore T cell biology and tumor immunology, helping... ...Design and perform in vitro and in vivo experiments... ...with in vivo models such as syngeneic or humanized...Local areaRelocation package
$183k - $238k
...multiple cellular aspects of in-vitro biology are at the heart of insitro's efforts... ..., systems biology, graph-based modeling, causal structure learning, single cell omics, or imaging modalities.... ..., and other machine learning scientists, support the identification of novel...Home officeFlexible hours3 days per week$215k - $235k
...Imaging based phenotyping of in-vitro biology is at the heart of insitro's... ...-house. As an Imaging ML Scientist, you will develop ML-... ...development Experience developing models for diverse computer vision... ...home office setup ~ Monthly cell phone & internet stipend ~...Home officeFlexible hours3 days per week$200.9k - $257.5k
...Machine Learning Scientist / Senior Machine Learning Scientist, Virtual Cell San Francisco Bay Area, CA; San Diego, CA Our Mission Our mission... ...developing multi-modal generative foundation models for multiscale biology. In this role, you will be an integral...Contract workWork experience placementLocal area- ...Description Job Description Scientist I Location: South... ...that meet strict in vitro and in vivo target criteria for tissue and cell-specific delivery of... ...therapy, and rodent models of immune-based... ..., DC and/or macrophage biology, and immune modulation....Full timeTemporary work
$120k - $160k
Scientist/Senior Scientist - T Cell Biology and T Cell Profiling in Autoimmune Disease We are a well-funded biotech startup that has developed a suite of... ...-cell functional screening with computational AI models to advance the development of immunotherapies for cancer...$103.4k - $192k
...Genentech’s Department of Cell and Tissue Genomics - Oncology... ...and highly motivated Scientist to drive discovery biology in the role of tumor suppressor... ...across cancer models and patient samples. The successful... ...datasets from in vitro models, in vivo studies, and...Local areaRelocation package- ...tissue Design and execute experiments in vitro to determine the impact of ultrasound on... ...Postdoc in neuroscience, molecular/cellular biology, biomedical engineering or another... ...experiences Experience in one or more of: Neural cell culture methods Human neural iPSC...Work experience placement
- Merck & Co. is searching for a motivated scientist for a laboratory-based role focusing on cell-based high-content imaging assays critical for drug discovery. Candidates should have a PhD in Biochemistry, Pharmacology, or related fields, alongside strong lab skills in...
$100.4k - $186.4k
..., refining preclinical models and accelerating therapeutic... ...and highly motivated Scientist III to join Genentech’s... ...data to inform disease biology and preclinical model... ...in human‑relevant in vitro models and translational... ...(e.g., primary immune cells, iPSC‑derived CNS cells...Local areaRelocation package- ...La Roche AG is seeking a highly motivated Scientist in South San Francisco to drive discovery... .... This position emphasizes single-cell and epigenomic profiling to explore epigenetic... ...leverage their expertise in computational biology and single-cell techniques, collaborating...Relocation package
- Scientist II - Oligonucleotides South San Francisco, United States | Posted on 03/20/2026 Our client, leadingleader in biotechnology and diagnostics... ...output Collaborate with cross-functional teams across biology, chemistry, and therapeutic areas (oncology, immunology,...
$103.4k - $192k
...to investigate novel pathways, biologics and potential therapeutic... ...and molecular mechanisms of T cell biology in inflammation and autoimmunity... ...and interpret experiments in vitro and in vivo to test novel... ...willingness to develop in‑vivo models. Strong communication skills...Local areaRelocation package- Dawar Consulting is seeking a Scientist specializing in Complex In Vitro Systems focused on Lung Biology in South San Francisco, California. The successful candidate will join a world leader in biotechnology and life sciences. This role requires expertise in innovative...
$163.67k - $221.44k
Career Category: Scientific Position Title Principal Scientist‑PKDM, Modeling and Simulation What you will do In this vital role you will contribute... ...and outside the PKDM department including chemistry, biology, toxicology, biomarkers and protein scientists. Basic Qualifications...Flexible hours$120k - $180k
...walks in. He's got access to a frontier model that isn't public yet and wants to understand... ...? The Role You'll be one of the founding scientists at the company. We're targeting first-in-... ...in the morning, run them through our cell assays by afternoon, test top candidates...Night shiftDay shiftAfternoon shift$156k - $191k
...advanced technologies and model systems to deepen our understanding of the biology that controls human... ...motivated and creative Scientist/Senior Scientist, Aging... ...bring deep expertise in cell biology, MOA studies, and... ...program direction Conduct in vitro and ex vivo studies to...Flexible hoursShift work$120k - $127.5k
...initiative bringing frontier AI models, massive compute, and... ...integrating frontier AI models, biological foundation models, and lab capabilities... .... Our technology powers scientists around the world, translating... ...powered biology to study how cells operate, organize, and work...Work at officeWorldwideRelocation package3 days per week
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