Principal Scientist, Antibody Discovery

Job Description

Job Description

Kelly® Science & Clinical is seeking a Senior/Principal Scientist, Antibody Discovery for a direct hire opportunity with a leading biopharmaceutical company in Mountain View, CA. If you are driven by the prospect of translating cutting-edge scientific discoveries into tangible advancements and are poised to advance your career, join us as we pioneer progress in the biotechnology and medical device industries.
Workplace: Onsite in Mountain View, CA
Position Title: Senior or Principal Scientist, Antibody Discovery
Position Type: Direct hire
Base salary range: 130,000-170,000 per year
Overview
Join a pioneering team at the forefront of antibody therapeutics innovation! We are an emerging biotechnology company based in the heart of Silicon Valley, harnessing proprietary in vivo technologies to accelerate the discovery of best-in-class therapeutic antibodies. Our mission: enable the industry to tackle its toughest drug targets with transformative efficiency and speed.
We are seeking a driven, collaborative [Senior / Principal Scientist] with a passion for hands-on discovery science to design, implement, and execute innovative antibody campaigns utilizing single B cell screening and advanced flow cytometry. Your expertise in both the strategic and technical aspects of antibody discovery will propel our pipeline—and your career—forward.
Key Responsibilities

• Establish and optimize a cutting-edge single B-cell workflow, focusing on antigen-specific enrichment and molecular recovery of antibody variable regions
• Develop, QC, and manage critical reagents and resources for B-cell workflows and antibody characterization—including protein labeling, cell-line management, and antibody conjugation.
• Perform, analyze, and interpret antibody screens for binding and functional activity using ELISA, flow cytometry, and diverse biochemical/cell-based assays.
• Select and maintain cell lines optimized for high target expression and robust screening outcomes.
• Lead the adoption of new technologies, automation tools, and innovative processes to continually advance antibody discovery efficiency.
• Coach, mentor, and guide junior scientific staff.
• Effectively communicate progress, discoveries, and challenges to multidisciplinary internal and external project teams and company leadership.

Qualifications

• Demonstrated technical mastery in multicolor flow cytometry—including panel design and operation on high-performance FACS systems (e.g., BD FACSAria™, Sony platforms) for precise rare B-cell isolation.
• MS (with 4+ years industry experience) or PhD (with 3+ years industry experience) in Molecular Biology, Biochemistry, Immunology, or similar field—and a proven scientific record.
• Strong hands-on experience with single B-cell platforms (e.g., Bruker/Berkeley Lights Beacon, Sphere Fluidics Cyto-Mine, or similar high-throughput systems) to isolate and recover antigen-specific antibody candidates.
• Practical expertise in molecular recovery and sequence analysis post-single cell screening (e.g., RT-PCR, plate-based cloning, next-gen sequencing workflows).
• Advanced lab skills in cell culture, molecular biology, high-throughput screening, and assay development.
• Experienced at balancing multiple high-impact projects in a fast-paced, deadline-driven setting.
• Strong communicator and effective collaborator, motivated by scientific discovery and innovation.

Why Join Us?
We’re passionately invested in creating new therapies that address serious unmet medical needs.
Competitive rewards: Industry-leading compensation, equity, annual bonus, comprehensive benefits
Work-life balance: Generous PTO, plus two annual company-wide one-week breaks
Growth & culture: Dynamic, entrepreneurial environment; robust professional development; open communication; a commitment to supporting all backgrounds and experiences
Impact & Community: Be part of a cohesive, diverse team, advancing technology and delivering medicines that matter
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Why Kelly® Science & Clinical?

Kelly Science & Clinical is your connection to premier scientific and clinical companies looking to hire industry experts just like you. Our team creates expert talent solutions to solve the world’s most critical challenges. Every day, we match science professionals with dream jobs that fit their skills, interests, and career goals-it’s the way we think job searching should be. Nearly 100 percent of our science recruiters have a professional background and education in science, so we know a thing or two about the science market and how to get your expertise noticed.

About Kelly

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