Scientist, Pharmacokinetics

Job Description This position will support our Company’s biologics drug discovery and development efforts in the Drug Metabolism and Pharmacokinetics (DMPK) Group within the Pharmacokinetics, Dynamics, Metabolism and Bioanalytics (PDMB) organization at our Research & Development Division in South San Francisco. The successful candidate will be a laboratory‑based scientist responsible for generating in‑vitro and in‑vivo ADME and pharmacokinetic data to support biologics programs. The role applies strong foundational expertise in protein biochemistry and biophysics to understand how molecular properties influence clearance mechanisms and PK/PD relationships of biologics including antibodies, bi‑/multi‑specifics, peptides, conjugates, and other novel modalities. We are seeking a flexible, curious, and proactive scientist with strong protein biochemistry/biophysics expertise and a passion for both reliably executing routine, decision‑enabling assays and developing and optimizing new assays that support biologics programs across multiple therapeutic areas. Candidates who are enthusiastic about supporting pipeline needs through high‑quality, reproducible assay execution, motivated to investigate mechanistic drivers of protein interactions, and interested in automation and biophysical techniques are especially encouraged to apply. Key Responsibilities Perform routine and exploratory biochemistry and biophysics‑based assays, including protein biochemistry and biophysical interaction assays to quantify receptor binding, cellular trafficking and degradation, non‑specific binding/clearance and other DMPK properties of biologics. Partner with cross‑functional teams to design, optimize, and execute assays aligned with project needs. Generate and analyze data with high attention to detail, and maintain complete and accurate electronic laboratory notebooks. Contribute to the implementation of automation solutions and semi‑automated workflows to increase throughput and reproducibility. Support the development and optimization of protocols and standard operating procedures and maintain and troubleshoot instruments. Communicate experimental plans and results clearly via written reports and verbal presentations. Qualifications Education: Bachelor’s (with 3+ years) or Master’s in biochemistry, biophysics, biotechnology, bioengineering, pharmacology or a related scientific discipline and relevant laboratory experience. Required Experience and Skills: Strong foundation in protein biophysics/biochemistry principles, with the ability to apply these concepts in a biological or translational context (e.g., protein interactions, binding kinetics, intracellular trafficking, in vivo clearance). Hands‑on experience with biochemical/biophysical techniques to characterize proteins (e.g., immunoprecipitation, flow cytometry, mass spectrometry, SPR/BLI, meso‑scale discovery, fluorescence spectroscopy, NMR/HDX/MS). Ability to analyze, troubleshoot, organize, and interpret data, with familiarity using software such as GraphPad Prism, Excel, or similar tools. Excellent attention to detail, strong documentation practices, and the ability to work in a fast‑paced research environment. Strong interpersonal, problem‑solving, and communication skills with a collaborative and growth‑oriented mindset. Preferred Experience and Skills: Experience with biologics DMPK assays, such as receptor binding kinetics, drug/receptor internalization, and cellular trafficking assays. Experience in cell culture and execution of cell‑based functional assays. Experience quantifying protein concentrations in biological matrices using ligand‑binding assays (e.g., ELISA, meso‑scale discovery, etc.). Prior experience with Octet/BLI, SPR, or similar biophysical techniques. Exposure to automation, liquid handlers, or high‑throughput assay systems. Required Skills: Biochemistry, Biophysics, Flow Cytometry, Fluorescence Spectrometer, Intracellular Trafficking, Kinetic Studies, Mass Spectrometry (MS), Molecular Biophysics, Protein Interactions. Preferred Skills: None specified. Salary & Benefits Salary range: $108,000.00 – $170,100.00 (lowest to highest and based on relevant factors). Eligible for annual bonus and long‑term incentive, if applicable. Comprehensive benefits package including medical, dental, vision, health insurance, retirement benefits (401(k)), paid holidays, vacation, and compassionate and sick days. Equal Employment Opportunity As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit the EEOC, EEOC Know Your Rights, GINA Supplement, and California, Colorado and other U.S. State Acts related to equality. Location & Eligibility San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance. Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance. Application Information Users are invited to apply for this role through the company’s career portal. Current Employees may apply via the Employee Job Opportunity portal; contingent workers may apply through the designated external portal. Contact & Additional Information Applications are managed through the company’s hiring system. Contact information for hiring managers or recruiters is provided within the application portal. The company seeks to provide reasonable accommodations for applicants who need them during the application or hiring process. #J-18808-Ljbffr MSD Malaysia