Post-Doctoral Research Fellow - Inner Ear Regeneration

Overview A postdoctoral fellow position is available on inner ear regeneration for hearing recovery from deafness, using reprogramming, animal models, and bioengineering approaches. The focus of the project is to regenerate diverse inner ear cell types including hair cells, neurons and other cell types in adult animal models (mice and pigs) and restore hearing from deafness. We have uncovered a major mechanism of Myc/Notch co-activation that induces proliferation and hair cell regeneration in the mature mammalian inner ear (Shu et al., NatCommon 2019). We have developed a cocktail of drug-like molecules potent in reprogramming and hair cell regeneration in adult cochlea in vivo (Quan et al., PNAS 2023). We have recently identified key molecules that promote ganglion neurite outgrowth and regeneration of synapses. The exciting results set the stage to advance the work for hearing restoration and the treatment of "hidden hearing loss" due to synaptopathy. We use state-of-the-art technologies, including in vitro adult cochlea explant culture, reprogramming, scRNAseq, genome editing, nanoparticle delivery and physiological function study. Our laboratory is at the forefront of developing treatments for hearing loss. We have conducted the first successful OTOF gene therapy clinical trial in children born with complete hearing loss, with the restoration of hearing and speech capability (Lv et al., The Lancet, 2024). The positions present unique and exciting opportunities for candidates interested in cutting-edge interdisciplinary research of advancing basic research to translational applications using molecular, cellular, genetics, gene editing and animal models to study inner ear cell regeneration and to explore the potential for functional recovery of hearing from animal models to humans. The laboratory is part of Eaton-Peabody Laboratories, the largest hearing research center with diverse hearing research programs. Responsibilities Advance inner ear regeneration research through reprogramming, gene editing, and animal studies to restore auditory function. Investigate delivery vehicles (viral and non-viral) for efficient targeting of inner ear cell types with minimal toxicity. Utilize human inner ear organoids and in vivo models to optimize hair cell regeneration and functional recovery. Employ state-of-the-art technologies (in vitro cochlea explant culture, scRNAseq, nanoparticle delivery, and physiological function assessment) to test hypotheses. Collaborate on projects exploring Myc/Notch co-activation as a mechanism for hair cell regeneration and explore synaptopathy-related hearing restoration. Contribute to manuscript preparation and dissemination of findings through scientific publications. Qualifications Ph.D., M.D./Ph.D., or MD with strong experimental training in molecular, cellular, genetics, enhancer design, gene editing and/or animal models relevant to inner ear biology. A track record of scientific publications and experience with at least some of: reprogramming, genome editing, inner ear biology, organoid culture, or auditory neuroscience. Strong analytical and communication skills, ability to work in a collaborative, interdisciplinary environment. Massachusetts Eye and Ear Infirmary is an Equal Opportunity Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. #J-18808-Ljbffr Massachusetts Eye and Ear Infirmary - MEI