Systems Engineer

Systems Engineer IIClient Diagnostics develops and produces medical tests and digital tools that provide information to help healthcare professionals find the right treatment for patients and deliver the best patient care to improve, prolong, and save lives. The Client Sequencing team is seeking a passionate Systems Engineer II to join the Systems Integration Group supporting Next Generation Sequencing, or NGS, products. This is a hands-on role in which the Systems Engineer II will contribute to feasibility, development, and integration activities for end-to-end NGS solutions. As a member of the Systems Integration team, this individual will work with the Single Molecule Sequencing platform to optimize operating protocols, design and perform wet-lab experiments, support integration of system subcomponents, and help improve the overall sequencing solution.Key Responsibilities:Design, execute, analyze, and document experiments to support feasibility, development, integration, verification, and validation of NGS workflows.Perform sample preparation, library preparation, sequencing-related experiments, and verification studies.Use the Single Molecule Sequencing platform to optimize final operating protocols and support system-level integration activities.Interpret experimental results using appropriate experimental design and statistical analysis methods.Troubleshoot instrument, workflow, or assay-related failures using standard root cause analysis methods.Collaborate with subject matter experts to understand failure modes and identify appropriate solutions.Develop, execute, and document test cases based on product requirements for verification and validation activities.Maintain accurate, well-organized, and concise laboratory records using best laboratory practices.Work cross-functionally with assay, instrumentation, software, bioinformatics, and systems teams to resolve integration challenges.Support continuous improvement of sequencing performance, including coverage, throughput, robustness, reproducibility, and overall system reliability.Required Qualifications:Bachelor's degree in chemistry, science, engineering, or a related field with 5 years of relevant experience, or a Master's degree in a related field with 1–3+ years of relevant experience.Demonstrated hands-on experience with PCR, DNA sequencing methods, raw sample preparation, nucleic acid extraction, library preparation, and/or NGS sequencing.At least 2 years of experience using MATLAB, Git, Python, or similar tools for data analysis and/or automation.Experience with statistical tools and methods, such as Python, JMP, regression analysis, and ANOVA.At least 2 years of experience with Design of Experiments methodology and application of statistical process control.Demonstrated ability to troubleshoot technical issues and identify root causes in laboratory, instrument, or workflow settings.Strong documentation skills and commitment to following best laboratory practices.Preferred Qualifications:Proven track record of performing in a fast-paced, matrixed environment.Ability to work independently while collaborating effectively across functions.Demonstrated ability to influence technical decisions and stakeholders without direct authority.Experience solving unique, ambiguous, or unpredictable problems that may impact project or organizational goals.Strong planning, prioritization, multitasking, and follow-through skills.Highly energetic, focused, and adaptable working style.Strong interpersonal, verbal communication, and relationship-building skills.Demonstrated ability to build and maintain effective relationships with key stakeholders.Location: This position is based on-site in Santa Clara, CA. This is not a hybrid position. Relocation benefits are not available for this role.