Feasibility Principal Analyst [Remote]

Feasibility Principal Analyst - Home-Based (US)

ICON plc is a world-leading healthcare intelligence and clinical research organization. We’re proud to foster an inclusive environment driving innovation and excellence, and we welcome you to join us on our mission to shape the future of clinical development.

Reporting to the Director of Feasibility, the Feasibility Principal provides strategic, study-level feasibility leadership within the Patient and Site Engagement (PSE) team, supporting the acceleration of clinical studies across rare disease programs. This role leads feasibility strategy and analysis for assigned studies, translating complex operational and enrollment data into clear, data-driven recommendations that inform study planning and enrollment decisions. Working cross-functionally, the Feasibility Principal also contributes to continuous improvement efforts and mentors junior team members, while operating effectively in a fast-paced, dynamic environment.

What You Will Be Doing:

• Working closely with, and under the strategic guidance of, the PSE Director or Associate Director, the Feasibility Principal leads feasibility activities for assigned clinical studies.

• Lead feasibility strategy and execution at the study level, supporting trial optimization and delivery of key milestones, while ensuring alignment with broader program objectives and feasibility standards.

• Synthesize and analyze feasibility, operational, and enrollment data from multiple internal and external sources to develop a comprehensive understanding of therapeutic areas, standard of care, disease progression, patient and site profiles, and the competitive landscape.

• Evaluate the clinical trial landscape and apply advanced data mining and analytical approaches, including complex enrollment modeling and forecasting, to translate findings into data-driven enrollment assumptions, risk assessments, and strategic recommendations.

• Operate effectively in a fast-paced, dynamic study environment, rapidly assessing changing inputs, reprioritizing work, and adjusting feasibility approaches to meet tight timelines.

• Apply strong time management and prioritization skills to balance multiple studies and last-minute requests while maintaining analytical rigor and clear communication.

• Serve as a key feasibility partner with cross-functional study teams, clearly communicating insights, assumptions, risks, and recommendations to support study planning, site selection, and enrollment strategy decisions.

• Lead and deliver data-driven presentations to cross-functional teams and governance forums, including presenting analyses and responding to questions from senior leadership, as appropriate.

• Mentor and provide guidance to junior feasibility team members, supporting development of analytical skills, best practices, and consistency in deliverables.

• Apply strong operational judgment and clinical trial expertise to proactively identify challenges, anticipate risks, and drive solutions.

• Contribute to continuous improvement of feasibility processes, tools, and best practices by sharing insights and lessons learned.

Your Profile:

• Bachelor’s degree in a scientific or allied health field (or equivalent industry experience), with 7+ years of progressive experience in clinical research, feasibility, clinical operations, or study startup within a sponsor or CRO environment.

• Minimum of 5 years of hands-on operational feasibility experience supporting complex studies or programs.

• Demonstrated experience leading feasibility strategy for complex studies or programs, with a proven track record of influencing decisions related to site selection, enrollment strategy, and study acceleration.

• Experience working across multiple therapeutic areas or late-phase programs with increasing strategic accountability.

• Demonstrated ability to analyze, synthesize, and interpret complex feasibility, operational, and enrollment data, translating findings into clear insights and actionable recommendations.

• Advanced proficiency in Excel and other data-driven analysis tools, including experience in structuring, analyzing, and presenting data for feasibility assessments, benchmarking, and enrollment forecasting.

• Strong verbal and written communication skills, with the ability to clearly present complex, data-driven analyses to diverse stakeholders.

• Demonstrated critical thinking and solution-oriented, creative problem-solving skills.

What ICON can offer you:
Our success depends on the quality of our people. That’s why we’ve made it a priority to build a diverse culture that rewards high performance and nurtures talent.

In addition to your competitive salary, ICON offers a range of additional benefits. Our benefits are designed to be competitive within each country and are focused on well-being and work life balance opportunities for you and your family.

Our benefits examples include:

• Various annual leave entitlements
• A range of health insurance offerings to suit you and your family’s needs.
• Competitive retirement planning offerings to maximize savings and plan with confidence for the years ahead.
• Global Employee Assistance Programme, LifeWorks, offering 24-hour access to a global network of over 80,000 independent specialized professionals who are there to support you and your family’s well-being.
• Life assurance
• Flexible country-specific optional benefits, including childcare vouchers, bike purchase schemes, discounted gym memberships, subsidized travel passes, health assessments, among others.

Visit our careers site to read more about the benefits ICON offers.

At ICON, inclusion & belonging are fundamental to our culture and values. We’re dedicated to providing an inclusive and accessible environment for all candidates. ICON is committed to providing a workplace free of discrimination and harassment. All qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.

If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or in order to perform the essential functions of a position, please let us know or submit a request here

Interested in the role, but unsure if you meet all of the requirements? We would encourage you to apply regardless – there’s every chance you’re exactly what we’re looking for here at ICON whether it is for this or other roles.

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