Product Manager, AI Platform & Partnerships

Manifold Bio is a platform biotechnology company pioneering AI-guided protein design and massively multiplexed in vivo screening to unlock tissue-targeted medicines and organism-scale models of living systems. Using proprietary molecular barcoding technology, we screen hundreds of thousands of protein designs simultaneously in living systems, producing in vivo-validated datasets at a scale no one else can match. The datasets power our computational models, which leads to better drug designs, creating a flywheel that gets stronger with every campaign. Our team of protein engineers, biologists, and computational scientists works across this full stack to pursue programs both internally and with leading pharma companies.PositionManifold Bio is seeking a Product Manager to serve as the internal product owner for our AI projects, leading the roadmap across key domains including protein design, foundation models, reasoning models, agents, and infrastructure. This role covers both internal product management and liaising with AI / tech partners., Internal responsibilities include interfacing with the AI team and R&D project managers to translate ambitious AI x biology ideas into shipped internal products and platform capabilities. External responsibilities include developing and nurturing relationships with external AI teams and partners, with an opportunity to flex into business development and strategic transactions. This role works closely with our co-founders, AI/ML leadership, and BD team to turn cutting-edge capabilities into durable platform assets.ResponsibilitiesDefine the product vision, roadmap, and success metrics for Manifold’s AI platform capabilities, including protein design, foundation models, and agentsTranslate internal R&D and AI x biology ideas into concrete requirements and run the operating cadences that drive decisions and accountabilityOwn Manifold's strategy for engaging the AI ecosystem; decide which partners to prioritize, what to build with each, and how to sequence engagementsCoordinate cross-functional execution across AI/ML, protein engineering, biology, and platform teams for partnerships and platform developmentSource, qualify, and close new AI partnership opportunities, leading exploratory conversations through to signed scopeOwn the quality of all external deliverables including reports, decks, and demos, and produce executive-ready memos to align internal stakeholdersRequired Qualifications2-5 years of product management, technical program management, alliance management, or BD experience, with at least part of that in AI/ML or computational product environmentsBachelor's degree in a technical field (CS, engineering, biology, or related); advanced degree a plusDemonstrated ability to own complex, ambiguous strategic relationships and drive them to concrete value generating outcomesStrong working knowledge of modern AI/ML concepts (foundation models, training and evaluation, agentic systems, scaling laws) and how they apply to scientific and industrial problems specific to drug discoveryFamiliarity with biology, protein engineering, drug discovery, or another applied scientific domainExceptional written communication; ability to produce executive-ready memos, decks, and external deliverables independentlyTrack record of running cross-functional execution in matrixed organizations and shipping on aggressive timelinesComfort operating in high-ambiguity, fast-evolving partnerships where the product itself is being defined as you goDemonstrated handle of agentic coding skills; e.g. ability to rapidly run analyses / generate figuresPreferred QualificationsExperience building or shipping products at a frontier AI lab, AI infrastructure company, or AI-first startupExperience structuring partnership terms in collaboration with BD and legal (data rights, IP, joint roadmaps)Public writing, talks, or other evidence of unusually strong communication abilityExperience scaling a partnership function or building partnership operating processes from scratchIf you’re excited to use unique protein technologies to shape an innovative drug development strategy, build meaningful industry partnerships, and contribute directly to our mission of advancing breakthrough treatments, please apply!Base Salary Range: $165K-275KThis reflects the typical offer range for this role, based on experience, role scope, and internal equity. Final compensation decisions are made using a consistent leveling framework and consider the candidate’s experience, interview performance, and expected impact.This role is eligible for:Annual performance-based target bonusStock optionsComprehensive medical, dental, and vision coverage401(k) planFlexible paid time off and holidaysPerks including on-site gym, onsite lunch, and commuter supportOur compensation ranges are reviewed annually to ensure alignment with market trends and internal equity.We value different experiences and ways of thinking and believe the most talented teams are built by bringing together people of diverse cultures, genders, and backgrounds.