Senior Scientist II (Preclinical Bioanalysis)

Summary / Job Purpose The Senior Scientist II of preclinical bioanalysis provides preclinical bioanalytical support for the advancement of the biologics portfolio at Exelixis. The incumbent must have strong LCMS-based bioanalysis experience as s/he supports preclinical activities of ongoing and new projects in antibody drug conjugates and other biologics. Essential Duties and Responsibilities Independently design and execute assay development and qualification of ADCs or other biologics in rodent and NHP matrices; perform pharmacokinetic sample analyses in support of proof‑of‑concept studies on biologic oncology programs from discovery to lead selection. Design, implement and manage studies for pharmacokinetic characterization of biologic drug candidates conducted by CROs and in‑house as needed. Conduct critical scientific/technical data analysis and interpret experimental results. Interact and collaborate with internal departments to deliver quality and timely findings in support of drug candidate advancement. Effectively communicate scientific concepts, findings, and interpretations to multi‑disciplinary teams. Contribute to other translational biology efforts. Follow company intellectual property and compliance policies and practices. Comply with company health and safety policies and general laboratory practices. Supervisory Responsibilities Direct work to a CRO, consultant, or third‑party as necessary. Education, Experience, Knowledge & Skills Master’s degree in analytical chemistry, biology, or a closely related discipline and a minimum of seven (7) years of related experience. PhD degree in analytical chemistry, biology, or a closely related discipline and a minimum of two (2) years of related experience (preferred). Equivalent combination of education and experience. Experience: Hands‑on experience in assay development and sample analysis with LCMS-based bioanalytical assays for biologics is essential. Scientific understanding of in vitro and in vivo pharmacology, PK, and PD concepts in cancer biology is important. Knowledge/Skills: Demonstrated drive for rigorous scientific excellence; ability to think critically and creatively to identify and solve scientific problems; knowledge and familiarity in LC‑MS-based bioanalysis is critical; ability to work independently with good time‑management and organizational skills; knowledge and experience of ligand‑binding assays and metabolite ID is a plus; excellent written, oral, and interpersonal communication skills; strong team player; advanced knowledge in Excel, Word, PowerPoint, PDF, GraphPad Prism; good tracking record and report writing. Working Conditions Environment: primarily working in laboratories or in office. Exposures encountered, such as hazardous materials and extreme cold. Travel required (up to 10%). Compensation and Benefits Compensation reflects the cost of labor across several U.S. geographic markets and varies based on the specific work location. The base pay range for this position is $132,500–$188,000 annually, adjusted for geographic region, job‑related knowledge, skills, experience, and internal equity. In addition to the base salary, Exelixis offers a comprehensive Total Rewards program, including a 401(k) plan with generous company contributions, group medical, dental, and vision coverage, life and disability insurance, and flexible spending accounts. Employees are eligible for a discretionary annual bonus program; field‑sales staff may qualify for a sales‑based incentive plan. The company also offers stock purchase opportunities, long‑term incentives, 15 accrued vacation days in the first year, 17 paid holidays including a company‑wide winter shutdown in December, and up to 10 sick days per year. Disclaimer The preceding job description has been designed to indicate the general nature and level of work performed by employees within this classification. It is not designed to be a comprehensive inventory of all duties, responsibilities and qualifications required. We are an Equal Opportunity Employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity, veteran status, or disability. #J-18808-Ljbffr Exelixis Inc