Founding Scientist
Aspire Life Sciences Search
Have you ever wanted to take full ownership of a drug discovery programme, from initial idea through to first in human? This is an opportunity to join a venture-backed, AI native biotech at the earliest stage and play a central role in shaping how programmes are built, prioritised and advanced. You will not be inheriting a function. You will be helping define it. About the company Our client is building a new type of biotech. A small, high agency team focused on developing novel therapies for diseases with limited treatment options, using a combination of modern AI-enabled biology and a highly leveraged external model. Rather than scaling large internal teams, they partner with best-in-class computational and wet lab CROs, allowing them to run multiple programmes in parallel while staying lean and focused. The founding team brings deep expertise in AI-driven biology and early discovery, with an ambition to build a new generation of virtual biotech capable of moving quickly from idea to clinical validation. The role This is a founding-level hire, intentionally broad in scope and high in impact. You will operate across the full lifecycle of drug discovery and early development, with real ownership of programmes rather than a narrow functional remit. Key responsibilities include: Defining and prioritising therapeutic programmes, including target selection and disease focus Shaping translational strategy, including biomarker plans and disease models Identifying programme risks and designing mitigation strategies Driving preclinical development from concept through to IND enabling studies Working closely with CRO partners across both computational and experimental workflows Helping build the scientific and operational foundations of the company You will also play a role in company building, from engaging external experts to selecting tools and shaping how work gets done. What they are looking for There is no single background that defines the right profile. This could suit: A senior scientist in translational biology or early development who wants greater ownership Someone from a biotech or academic environment who has worked across multiple stages of the discovery process A future founder looking to gain hands on experience at the earliest stage of company building An individual with strong biological depth and a clear track record of learning quickly across disciplines Core attributes Deep biological understanding in any relevant discipline High agency and comfort operating in ambiguity Strong intellectual curiosity and ability to self direct learning Comfort operating in a tech enabled biology environment, including hands on familiarity with computational tools and basic Python or similar coding for practical use Genuine engagement with modern AI driven approaches to biology, beyond conceptual interest, with evidence of applying or experimenting with these tools in practice A practical mindset around translating science into viable programmes What sets you apart Experience identifying and validating therapeutic targets or pathways Exposure to both discovery and preclinical development Evidence of building something meaningful, whether research, tools or programmes Interest or experience in immunology, neurodegeneration or related areas Why this role This is not a typical hire into an established structure. It is an opportunity to shape both the science and the way the company operates, working closely with a founding team that is already thinking differently about how biotech should be built. #J-18808-Ljbffr Aspire Life Sciences Search
- United States Digital Space LLC in San Francisco is seeking a Founding Machine Learning Scientist to join their team. This role focuses on using generative machine learning to design bacteriophages for treating antibiotic-resistant infections, helping to expedite phage...SuggestedFull time
- ...MassSpecGym benchmark. We are now developing the next generation of this model. Role description We are looking for a founding machine learning scientist to design and advance models that infer molecular structure and properties directly from mass spectrometry data. You...SuggestedVisa sponsorshipShift work
- Multifactor (YC F25) in San Francisco seeks a Founding Scientist — a founding executive who will own the hardest open problems on Multifactor's roadmap and carry the answers all the way into production. This role blends research with building and shipping, working directly...Suggested
- A pioneering biotech firm in San Francisco is seeking a founding machine learning scientist to lead the development of a molecular foundation model for mass spectrometry. The role emphasizes ownership and autonomy in a fast-paced environment, focusing on modeling and inference...Suggested
- Novogaia is seeking a founding machine learning scientist to design and advance models that infer molecular structure and properties directly from mass spectrometry data. You will take ownership of Gaia-02, extending spectrum-to-structure reasoning and collaborating closely...Suggested
- the company | Founding Machine Learning Scientist | San Francisco, CA | ONSITE | Full-time We use generative ML to design bacteriophages that treat antibiotic-resistant superbugs (bacterial infections). Using phages in this way is not a new idea. Phages already cure patients...Full timeImmediate start
- Aspire Life Sciences Search seeks a founding-level hire to lead drug discovery from idea to first in human. This role offers ownership over therapeutic programmes and pivotal involvement in shaping the company's scientific and operational foundations. The ideal candidate...
- Nurix Therapeutics, Inc. is seeking a hands-on antibody conjugation scientist to build capability from the ground up, integrating chemistry, automation, and analytics to move candidates toward study-ready material. The role partners with medicinal chemistry, analytical...
- Nurix Therapeutics, Inc. is seeking a hands-on antibody conjugation scientist to build a new capability from the ground up, linking bioconjugation chemistry to automated, high-throughput workflows for in vivo and translational studies. You will develop and optimize antibody...
- ...orgs from 3 people to 50. We've published AI research with real citations behind it and hold multiple patents. We're now hiring the founding researchers on our team — not the fortieth — and you'd be building next to us from day one. What you’ll own What we do The...Full timeImmediate startVisa sponsorship
$200k - $300k
PassFort is seeking a Founding ML Researcher in San Francisco to shape the company's ML research and drive the engineering archetype. You will own the ML lifecycle, from research to production deployment, and collaborate directly with the founders. The ideal candidate...Full time- Physical AI in San Francisco is hiring the founding researchers to accelerate hardware design with AI. You will co-create models trained on board physics, guiding from problem formulation through validated testing to production-ready boards. Equity and a chance to shape...Visa sponsorship
- ...with a stealth startup within the WealthTech space who specalizes in building AI Native Portfolio Management tools in search for a Founding Quant to join their organization. We are looking for an individual who has deep experience in portfolio contruction, mangament,...
$200k - $300k
Founding ML Researcher San Francisco In office Full-time We are hiring a Founding ML Researcher in San Francisco. We are building a small, talent-dense team. This role will define the engineering archetype at Unsiloed AI and set the ceiling for the team. We strongly...Full timeWork at officeVisa sponsorship$225k - $300k
A stealth startup in WealthTech is seeking a Founding Quant in San Francisco to develop advanced portfolio management tools. Candidates should have a strong background in portfolio construction and asset allocation, with proficiency in Python and AI methodologies. This...$340k - $380k
...into company-level decisions.We’re looking for a senior Data Scientist to be the first dedicated data science hire on the Pricing team... ...excellent pricing data science looks like.About the RoleAs a founding Data Scientist for Pricing, you will design the analyses, models...Casual workWork at officeLocal areaFlexible hours- ...experience with any method. Top-performing Fellows will be offered permanent research positions. Few are present, in any era, at the founding of a new instrument of discovery. Bring the problem worth your year. Other Info For US Remote/Hybrid: This position requires...Permanent employmentFull timeRemote workVisa sponsorshipRelocation package
- ...fully in‑person in our SF office. About The Role As a Research Scientist at Phonic, you'll drive original research that pushes the boundary... ...What You’ll Bring A track record of original research - you've found a real problem, developed a novel approach, and seen it through...Work at office
$155k - $269k
...Waabi, founded by AI visionary Raquel Urtasun, is the leader in Physical AI. With a world-class team, we're unlocking the next era of... ...scalable, controllable, and efficient simulation. As a Research Scientist in World Models, you will develop algorithms and productionise...Full timeWork at officeWork from homeFlexible hours$210k - $360k
...AI advances and new use cases emerge, high-quality training data is the bottleneck. This is where David AI comes in. David AI was founded in 2024 by a team of former Scale AI engineers and operators. In less than a year, we’ve brought on most FAANG companies and AI labs...Work at office- ...Anthropic invites applications for a Research Scientist in Life Sciences. You’ll help build a high-impact biology research group at the... ...biology, shaping AI-driven biological discovery. As a founding member, you’ll establish methods, work with world-class AI researchers...
- ...cementing its position as the leader in enterprise generative AI. Founded in 2020 with office hubs in San Francisco, New York City,... ...enterprise AI deployments in the world. As a staff AI research scientist, you'll be at the center of that work. You'll drive a high-impact...Full timeWork at officeLocal areaFlexible hours
- ...the datasets that power the next generation of multimodal AI. Founded by Lucas Mantovani (ex Meta FAIR) and Lucas Tucker (ex Adobe Infra... ...training data for frontier labs. We’re hiring a Research Scientist to develop and fine‑tune models for video and audio data processing...Immediate startShift work
- ...Role As a Research Scientist working at OpenEvidence, you will push the boundaries of what modern models are capable of, bringing a research... ..., and low-ego. Does that sound rare? It is rare, we have only found 30 of them, and we would like to find more. Location All full-...Full time
- ...AI models to design molecules and transform how new cures are found. We are a craft-obsessed team setting out to re-architect drug... ...Groom, Amplify, and many more. About the role As an AI Research Scientist, you will conduct groundbreaking research on computational modeling...
- ...Apply for the Founding Applied Scientist role at Koah . Overview Koah Labs is building the ad network to power the next generation of AI-native products. Our mission is to help publishers monetize and help advertisers reach the right audience — without compromising speed...
$160k - $225k
...achieve financial stability for themselves and their families while providing essential care to millions of people across the U.S. Founded in 2016, we are a remote-first team of over 1,000 people building a top YC company and have been profitable since 2022. We’re the leader...Work at officeRemote work3 days per week$128k - $184k
...Waabi, founded by AI visionary Raquel Urtasun, is the leader in Physical AI. With a world-class team, we're unlocking the next era of... ...and reliability. We are looking for a hands-on Applied Data Scientist to help drive a unified view of our multi-faceted evaluation methodology...Full timeWork at officeWork from homeFlexible hours- ...Founding Data ScientistThe platform sees more about a shipment than anyone else in the supply chain does. Your job is to turn that into prediction: models that flag the customs hold, the temperature excursion, and the silent carrier before the issue reaches a patient....Work at office
$190k - $265k
...uses algorithms with reasoning-adept LLMs that have been customized by our expert team of lawyers, engineers and research scientists. We’ve found product market fit and are scaling our team very quickly. Some reasons to join Harvey are: Exceptional product market fit:...Work experience placement
Do you want to receive more vacancies?
Subscribe and receive similar vacancies to Founding Scientist. Be the first to apply!
- molecular biology scientist San Francisco, CA
- water quality scientist San Francisco, CA
- machine learning scientist San Francisco, CA
- scientist antibody discovery San Francisco, CA
- image scientist San Francisco, CA
- machine learning research scientist San Francisco, CA
- hplc scientist San Francisco, CA
- materials scientist San Francisco, CA
- research associate scientist San Francisco, CA
- downstream processing scientist San Francisco, CA

