Principal Applied Scientist
$142.8k - $274.8kMicrosoft
Job ID: 200061197Posted: 2026-10-16Location: United States, Washington, RedmondSalary: USD $142,800 - $274,800 per yearEmployment type: Full-TimeWork site: 3 days / week in-officeRole type: Individual ContributorTravel: Less than 25%Profession: Research, Applied, & Data SciencesDiscipline: Applied SciencesCompany: MicrosoftOverviewFrontier Tuning is a new product that aims to fine-tune models and harnesses on tenant data, enabling enterprise-tuned agents and solutions. We are a small, nimble team that is advancing the state of the art in models and agents. Come join our team and help transform the agent experience in the enterprise.We are seeking a Principal Applied Scientist with strong research and development skills and the desire to develop the cutting-edge AI products that push technological boundaries. We are looking for candidates with interest and experience in designing, building, and deploying AI solutions, working with the latest cloud and ML technologies, and delving deep with customers to generalize their learnings into the broader product. We provide a nurturing environment to support passionate researchers and engineers in technology innovation. We seek candidates who excel in deep thinking, advanced development, and fast-paced entrepreneurial execution in a collaborative setting. Microsoft’s mission is to empower every person and every organization on the planet to achieve more. As employees we come together with a growth mindset, innovate to empower others, and collaborate to realize our shared goals. Each day we build on our values of respect, integrity, and accountability to create a culture of inclusion where everyone can thrive at work and beyond.ResponsibilitiesDesign, build, test, and deploy cloud-based AI applications Build and deploy LLM-based agentic systems. Engage with customers to understand and address their pain points. Document experiments and communicate results across the team. Mentor early in career team members. QualificationsRequired Qualifications:Bachelor's Degree in Statistics, Computer Science, Electrical or Computer Engineering, or related field AND 6+ years related experience (e.g., building software systems, research)OR Master's Degree in Statistics, Computer Science, Electrical or Computer Engineering, or related field AND 4+ years related experience (e.g., building software systems, research)OR Doctorate in Statistics, Computer Science, Electrical or Computer Engineering, or related field AND 3+ years related experience (e.g., building software systems, research)OR equivalent experience.Preferred Qualifications:Master's Degree in Statistics, Computer Science, Electrical or Computer Engineering, or related field AND 9+ years related experience (e.g., building software systems, research)OR Doctorate in Statistics, Computer Science, Electrical or Computer Engineering, or related field AND 6+ years related experience (e.g., building software systems, research)OR equivalent experience.5+ years experience creating publications (e.g., patents, libraries, peer-reviewed academic papers).2+ years experience presenting at conferences or other events in the outside research/industry community as an invited speaker.5+ years experience conducting research as part of a research program (in academic or industry settings).3+ years experience developing and deploying live production systems, as part of a product team.3+ years experience developing and deploying products or systems at multiple points in the product cycle from ideation to shipping.Applied Sciences IC5 - The typical base pay range for this role across the U.S. is USD $142,800 - $274,800 per year. There is a different range applicable to specific work locations, within the San Francisco Bay area and New York City metropolitan area, and the base pay range for this role in those locations is USD $188,000 - $304,200 per year. Certain roles may be eligible for benefits and other compensation. Find additional benefits and pay information here:This position will be open for a minimum of 5 days, with applications accepted on an ongoing basis until the position is filled.Microsoft is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to age, ancestry, citizenship, color, family or medical care leave, gender identity or expression, genetic information, immigration status, marital status, medical condition, national origin, physical or mental disability, political affiliation, protected veteran or military status, race, ethnicity, religion, sex (including pregnancy), sexual orientation, or any other characteristic protected by applicable local laws, regulations and ordinances. If you need assistance with religious accommodations and/or a reasonable accommodation due to a disability during the application process, read more about requesting accommodations.
$142.8k - $274.8k
...customer grounded quality issues with quality teams to advance Copilot quality and product innovation. We are looking for a Principal Applied Scientist to work directly with enterprise customers and Copilot teams translating high-value workflows expected outcomes and...PrincipalOngoing contractFull timeLocal area$142.8k - $274.8k
...research and planet-scale production systems powering technologies like GitHub Copilot and Azure OpenAI. We are looking for a Principal Applied Scientist to join our team! Microsofts mission is to empower every person and every organization on the planet to achieve...PrincipalOngoing contractFull timeWork at officeLocal areaShift work$142.8k - $274.8k
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...enterprisespecific capabilities are systematically learned and reflected across Microsoft 365 and beyond. We are seeking a Principal Applied Scientist with strong research and systemsbuilding skills who is excited to push the frontier of largescale model posttraining and...PrincipalOngoing contractFull timeWork at officeLocal areaWork from homeRelocation package2 days per week3 days per week$198.9k - $269k
The Principal Applied Scientist will own the science mission for building next-generation proactive and autonomous agentic experiences across Alexa AI's Personalization, Autonomy and Proactive Intelligence organization. You will technically lead a team of applied scientists...PrincipalWorldwideFlexible hours- ...growth company. And people who care—about each other, about UiPath, and about our larger purpose.Could that be you?As a Principal Applied Scientist, you will lead the architecture, research, and productization of these next-generation ML systems, bridging deep research...PrincipalWork at officeImmediate startRemote work
$198.9k - $269k
...management, the science problems are growing in complexity and strategic importance. The FBA organization is looking for a Principal Applied Scientist with deep expertise in Operations Research, Reinforcement Learning, and strong modeling and analytical skills to join our...PrincipalWorldwideFlexible hours$142.8k - $274.8k
...production systems as part of a product team. ~3 Years of experience in Auto-Bidding or Auction Design. #MicrosoftAI Applied Sciences IC5 - The typical base pay range for this role across the U.S. is USD $142800 - $274800 per year. There is a different...PrincipalOngoing contractFull timeWork at officeLocal area$192k - $304.75k
...with deep quantum computing domain expertise to path-find the future. As a Senior Quantum Error Correction Research Scientist for Quantum Computing Applied Research, you'll focus on technical pathfinding, helping to develop innovative technologies that advance the state...Full time$192k - $304.75k
...approach to accelerated computing. We're looking for a passionate scientist at the intersection of quantum device physics, quantum... ...help accelerate the entire quantum ecosystem. As a Sr. Quantum Applied Research Scientist, you will help design and build real-time models...Full timeRemote work$167.1k - $226.1k
...agencies, Amazon Leo will serve people and organizations operating in locations without reliable connectivity.The RoleAs a Senior Applied Scientist in Project Leo, you’ll be leading us in making critical and time sensitive decisions that impact customers. You’ll use your...Permanent employmentFlexible hours$142.8k - $274.8k
...Overview The Data Science & Applied AI (DSAAI) organization within Commerce Engineering & AI (CEAI) is leading... ...operations ecosystems. We are looking for a Principal Machine Learning Scientist to lead the development of next-generation AI systems,...PrincipalOngoing contractLocal area$119.8k - $234.7k
...to join a fast-paced, high-visibility, diverse team in a highly competitive market sound exciting to you? If so, this Senior Applied Scientist role with the Microsoft Turing team may be a great fit for you! The Microsoft Turing team is an innovative applied research...Ongoing contractWork at officeLocal areaWorldwideRelocation package3 days per week$186.12k - $211.8k
...pursuing undisclosed solid tumor targets.Position OverviewThe Principal Scientist, Clinical Pharmacology and Pharmacometrics will bring... ...late-stage and early preclinical/clinical development assets. Apply pharmacokinetic/pharmacodynamics (PK/PD), physiologic based PK...Principal$169.59k - $206.23k
...tumor targets.Position OverviewWe are seeking an experienced Principal Scientist, Chemical Development to join our dynamic team to help advance... ...targeted cancer therapies. The successful candidate will apply their expertise in small molecule process development and manufacturing...PrincipalAfternoon shift- ...Immunome seeks a Principal Scientist in Clinical Pharmacology and Pharmacometrics to lead quantitative pharmacology strategy across oncology drug candidates. The role involves applying PK/PD modeling and simulation to inform dose selection and development decisions for...Principal
$167.1k - $226.1k
Amazon Supply Chain Optimization Technology (SCOT) Optimal Sourcing Systems (OSS) is looking for an Senior Applied Scientist to help build the next generation strategic sourcing systems. The OSS owns the optimization of inventory sourcing and the orchestration of inbound...Temporary workWorldwideFlexible hours$167.1k - $226.1k
...actionable intelligence, and power autonomous agents that learn from every customer interaction. We are looking for a Senior Applied Scientist to lead the development of generative AI applications that change how finance teams work, tackling problems at the intersection...Contract workFlexible hours$167.1k - $226.1k
...Set technical direction for assessment science, mentor junior scientists, and present results to senior leadership- Publish research on... ...please visit for more information. If the country/region you’re applying in isn’t listed, please contact your Recruiting Partner.The...Flexible hours$192.2k - $260k
...of the movies and into our homes. If you're excited about this robotics revolution, come join Amazon's Fauna Robotics. As an Applied Scientist in this org, you'll push the state-of-the-art techniques in Robotics. You'll drive technical excellence in areas such as perception...Local areaFlexible hours$192.2k - $260k
...AI, world models, or related areas - with a strong interest in applying that expertise to robotics.Role OverviewThis is applied... ...robots perceive, plan, and navigate at Amazon scale.As an Applied Scientist on the Last Mile Robotics team, you will develop cutting-edge...Local areaFlexible hours$167.1k - $226.1k
...have to tell us about it and help customers adopt best practices while architecting on the cloud. We are looking for a Senior Applied scientist who will function as a science leader and drive innovation with Gen AI to bring paradigm shift to how the business operates and...Work at officeWorldwideFlexible hoursShift work$167.1k - $226.1k
...optimization to zip-code-level Sub Same Day siting. You will work alongside scientists, and with partner teams in GOES Portfolio Management, Capacity Planning and Finance.We are looking for an Applied Scientist to own the optimization models behind REOS. You will formulate...Full timeTemporary workSeasonal workFlexible hoursDay shift$167.1k - $226.1k
...time.Amazon Fulfillment Planning & Execution (FPX) Science team within SCOT- Fulfilment Optimization group is seeking a Senior Applied Scientist with expertise in Optimization and a proven record of solving business problems through scalable Optimization solutions. FPX...Temporary workWorldwideFlexible hours$189.4k - $256.2k
...fast delivery promise. The FBA organization is looking for a Principal Economist with expertise in economic and econometric... ...mechanism design to join our cross-domain group of economists, data scientists, applied and research scientists and scholars.As a lead economist,...PrincipalWorldwideFlexible hours$130k - $160k
...contributions to the company's success. SystImmune is seeking a Principal Scientist to join our Protein Engineering group and help advance novel... ...timelines, and compile comprehensive data reports. Apply deep antibody engineering expertise to the design,...PrincipalFull timeAfternoon shift$167.44k - $226.07k
...hypotheses, and success metrics ~ Lead applied research projects: literature review,... ...transfers Experience mentoring more junior scientists and engineers Experience working with... ...and maintain high technical standards. Principal Engineers at our company are expected to...Local area$192k - $304.75k
...accelerated computing. We're looking for a passionate AI research scientist with deep quantum computing expertise to path-find the future... ..., and our goal is to accelerate the entire ecosystem. As a Sr. Applied Research Scientist in Quantum Computing, you will architect and...Full time$130k - $160k
...contributions to the company's success. We are seeking a Principal Scientist to provide technical leadership for the development of... ...SystImmune is an Equal Opportunity Employer. We welcome diverse talent and encourage all qualified applicants to apply....PrincipalFull time- Virology - Principal Scientist / Senior Principal Scientist Location: Seattle, WA (onsite) Company: Venture-backed biotech (stealth mode) About... ...readouts to produce robust and interpretable data. Advance applied virology and lab operations Conduct serial-passage, escape-...Principal
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