Medical Science Liaison - Neurodegeneration (United States)

About Prilenia

Prilenia Therapeutics, a clinical‑stage biotechnology company focused on the urgent mission of developing novel therapeutics to slow the progression of neurodegenerative diseases and neurodevelopmental disorders.

We are a flexible, fast‑moving team that is quickly advancing a potential therapy poised to have major impact on the lives of patients and their families. Our lead product candidate, pridopidine, holds Orphan Drug Designation in both Huntington’s disease (HD) and amyotrophic lateral sclerosis (ALS) in the U.S. and EU, as well as Fast Track designation from the FDA for the treatment of HD. Prilenia is conducting global Phase 3 clinical trials in both HD and ALS. Pridopidine has the potential to be a pivotal treatment to address HD and ALS disease progression. Prilenia believes pridopidine’s novel mechanism of action as a Sigma‑1 receptor agonist also gives it potential in numerous other neurodegenerative and neurodevelopmental conditions.

To learn more about our story and company culture, visit us at

About the Role

We are seeking a highly motivated and experienced Medical Science Liaison (MSL) to join our dynamic Medical Affairs team in the United States. This is a field‑based role supporting the U.S. and Canada, reporting to the Executive Medical Director. The MSL will serve as a scientific expert in HD and ALS while building collaborative partnerships with neurologists, thought leaders and multidisciplinary care teams to support Prilenia’s clinical trials and programs.

Prilenia is a highly virtual and flexible organization and encourages team members to work in the ways that make them most effective, with a focus on our common goals and drive to move things forward.

KOL Engagement

• Identify, develop, and maintain relationships with KOLs, HCPs, and other stakeholders within the relevant therapeutic areas.
• Engage in scientific exchange to provide and gather medical and scientific insights.
• Represent the company at medical conferences, symposia, and meetings to establish and strengthen relationships with KOLs and other stakeholders.

Scientific Communication

• Provide accurate, unbiased, and up‑to‑date scientific information to healthcare professionals.
• Present clinical data and scientific information in various forums, including advisory boards, investigator meetings, and educational sessions.
• Serve as a scientific resource for internal and external stakeholders.

Medical Affairs Support

• Collaborate with cross‑functional teams, including Clinical, Research, Regulatory, Patient Advocacy and Commercial, to provide scientific input and support.
• Assist in the development of medical strategy and contribute to the execution of Medical Affairs plans.
• Support Clinical Development initiatives, including site identification and patient recruitment for clinical trials.

Market Insights

• Gather and communicate competitive intelligence and market insights to inform strategic decisions.
• Provide feedback to internal teams on trends and emerging science in the field.
• Leverage scientific knowledge and KOL relationships to identify opportunities for activities leading to scientific advancement.

Compliance

• Ensure all activities and interactions comply with applicable local and international regulations, company policies, and ethical standards.

Qualifications and Skills

• Education: Advanced degree in life sciences (MD, PhD, PharmD, or equivalent).
• Experience: Minimum of 5 years of reference‑supported high performance in a similar MSL role, preferably in a scale‑up and rare disease environment. Demonstrated experience working with KOLs and understanding of the U.S. and Canadian healthcare systems. Experience in neurology and neurodegenerative therapeutic areas relevant to the company’s pipeline is highly desired.
• Skills: Strong scientific acumen and ability to understand and effectively communicate complex scientific and clinical data. Excellent interpersonal and communication skills, both written and verbal. Ability to work independently and manage multiple priorities in a fast‑paced environment. Proficient in Microsoft Office Suite and familiar with CRM tools.

Location and Time Zones

• This is a full‑time, remote position in the U.S.
• Expected domestic/regional travel up to 70% with some international travel. A valid driver’s license is required.
• Flexible schedule with interactions across North American, European and Israeli time zones.

Equal Opportunity Employment

Prilenia is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, or veteran status. We are dedicated to fostering a diverse, inclusive, and welcoming workplace for all.

AI Tools in Hiring Process

We may use artificial intelligence (AI) tools to support parts of the hiring process, such as reviewing applications, analyzing resumes, or assessing responses. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed, please contact us.