Sign up to access all features of our service.
  • Job search
  • Favorites
  • Create a CV
    New
  • Salaries
  • Subscriptions

Senior MES Engineer

$145k - $180k

Macpower Digital Assets Edge

Job Summary:

  • Requires demonstrated technical proficiency in MES software design and configuration.
  • Must have experience integrating MES with Level 2 and Level 4 systems.
  • Responsible for leading a team of engineers to deliver MES solutions.
  • Directly interacts with customers to gather requirements and deliver full project life cycle execution.
  • This is a leadership role requiring strong problem-solving skills, interpersonal skills, business acumen, and relationship building.
  • Success is demonstrated by securing repeat business from both new and existing clients.
Work Model: 100% Onsite

Salary: $145,000-$180,000 base + uncapped bonus

Travel Requirement: Up to 25%


Key Responsibilities:
  • Design and deliver MES solutions and standards independently or by leading a team.
  • ct as a solution architect to conceptualize, detail, and implement MES systems.
  • Develop MES strategies that integrate process knowledge, equipment, quality standards, and IT systems.
  • Improve uptime, regulatory compliance, and process efficiency.
  • Lead project management activities such as planning, budgeting, scheduling, task prioritization, tracking, and reporting.
  • Manage project execution, financials, team communication, and profitability (up to $1M).
  • Lead status meetings and provide regular updates.
  • Oversee daily operations of assigned projects.
  • ct as a technical lead and guide junior engineers and technicians.
  • May serve as Project Manager for smaller-scale projects.
Required Qualifications:
  • Bachelor's degree in Engineering, Computer Science, or Applied Sciences is required.
  • More than 10 years of MES experience is preferred.
  • Proven deployment experience with Werum Client-X, Sepasoft, or POMS.
  • Experience across full MES lifecycle: concept, design, implementation, testing, start-up, and commissioning.
  • Life Sciences industry experience required.
  • Familiarity with regulations such as cGMP and 21 CFR Part 11.
  • Proficient in developing integrated EBR recipes using GAMP5, ISA-88 (S88), and ISA-95 (S95) standards.
  • Strong understanding of manufacturing processes and MES system configuration.
  • Knowledge of GMP warehouse and inventory management.
  • Experience with external interfaces like DeltaV, SAP, LIMS, PI, and Maximo.
  • Strong knowledge of historian and reporting systems.
  • Experience with SQL, Oracle, or other relational databases.
  • Knowledge of IT/OT networking.
  • Strong technical writing and verbal communication skills.
  • Proficiency in MS Office applications.
  • Demonstrated experience leading MES project teams.
  • Experience mentoring junior engineers.
  • ble to provide professional references (subordinate, peer, manager).
  • Willingness to travel up to 25%.
Physical Demands:
  • Must be able to see, hear, speak clearly, and use hands dexterously.
  • Requires driving, lifting, mounting/dismounting equipment, pushing, and pulling.
Work Environment:
  • Standard office, client site, and industrial environments.
  • Frequent use of computers, printers, copiers, and phones.

Interview Process:

  1. Phone screen with Talent Advisor.
  2. First technical interview (video).
  3. Final onsite technical interview.
Vacancy posted 2 days ago
Similar jobs that could be interesting for youBased on the Senior MES Engineer in Raleigh, NC vacancy
  •  ...About the job Senior MES Engineer Senior MES Engineer needs 10+ years experience Senior MES Engineer requires: MES solution deployment experience with but not limited to Werum PAS-X, Sepasoft, or POMS Proven experience with all phases of MES projects... 
    Senior

    Global Channel Management

    Raleigh, NC
    3 days ago
  •  ...ATS Company: PA Solutions Requisition ID: 16598 Location: Raleigh, NC, US, 27603 Date: Aug 13, 2026 Senior MES Engineer Your responsibilities We are seeking a Senior MES Engineer to support the expansion of our Manufacturing Execution Systems (MES) practice... 
    Senior
    Remote work

    ATS Automation

    Raleigh, NC
    3 days ago
  •  ...About the job Senior MES Engineer Summary The Senior MES Engineer will lead design, configuration, implementation, and commissioning of Manufacturing Execution System (MES) solutions with integration to Level 2 and Level 4 systems. Acting as a solution architect... 
    Senior
    Work at office

    Staff Finders Inc

    Raleigh, NC
    2 days ago
  • $141k - $180k

     ...requires demonstrated technical proficiency in software design and configuration of MES solutions with integration capabilities to level two and four systems. The Senior MES Engineer will interact directly with the customer and lead a team of Wunderlich-Malec engineers... 
    Senior

    Bryce Poynt Consulting

    Raleigh, NC
    4 days ago
  • ATS Company:  PA Solutions
    Senior

    PA Solutions

    Raleigh, NC
    4 days ago
  •  ...Description: We are seeking an experienced Senior Validation Specialist to lead...  ...internal/external audits. Collaborate with Engineering, Quality Assurance, Manufacturing, Automation...  ...Preferred Qualifications: Experience with MES, LIMS, SCADA, PLC, ERP, or other GMP computerized... 
    Senior

    Katalyst Healthcares & Life Sciences

    Raleigh, NC
    4 days ago
  • Flowserve is seeking a Sr. Order Engineer to join our Nuclear Valve Operations team in Raleigh, NC. This role serves as a critical link between customer requirements and manufacturing execution, ensuring engineering deliverables are completed accurately and efficiently... 
    Senior
    Full time

    Flowserve

    Raleigh, NC
    2 days ago
  • $116k - $258k

     ...analytical solutions, and OneSource services.Job TitleSenior Automation Engineer (cGMP) - Project FarmaLocation(s)Customer Site - AL, Customer...  ...-level experience with one or more aspects of Process Control, MES and Digital Systems platforms. Willingness to travel as required... 
    Senior
    Full time
    Remote work
    Work visa

    PerkinElmer

    Raleigh, NC
    4 days ago
  • RTX Corporation is seeking a Sr. Manager, SAP MES Integrations Analyst to drive SAP-MES integration efforts within the OneRTX program. You will lead design, build and testing of SAP and MES interfaces, work with cross-functional teams, and ensure reliable data flows across... 
    Senior
    Remote job

    RTX

    Raleigh, NC
    4 days ago
  • $100k - $130k

     ...development of groundbreaking therapies. Our mission is to be the engine of innovation for genomic medicine pioneers. As a member of our...  ...the Danaher Business System which makes everything possible.The Senior Engineer, Process Validation is responsible for leading &... 
    Senior
    Full time
    Remote work
    Work from home
    Flexible hours

    Danaher Corporation

    Raleigh, NC
    4 days ago
  •  ...below ****This position is part of the Protection and Control Engineering group located in the Duke Energy Progress headquarters in downtown...  ...as a Professional Engineer is required at the Senior level by Transmission.A Master's degree in Engineering will be... 
    Senior
    Full time
    Remote work
    Visa sponsorship
    Relocation package
    Monday to Friday

    Duke Energy

    Raleigh, NC
    3 days ago
  • Position OverviewPower your future with Qualus as a Senior Substation Engineer. Substation Design Engineers are responsible for designing substations utilizing applicable codes and client standards (if available). Typical design to include general arrangement, equipment... 
    Senior
    Full time
    Temporary work
    Work at office
    Flexible hours

    Qualus

    Raleigh, NC
    3 days ago
  •  ...creative minds to help shape it. If you're ready to help define what comes next, we'd love to meet you.Position SummaryAs Senior Gameplay Engineer, you are a versatile engineer who thrives in a collaborative environment and deeply enjoys empowering designers. You will... 
    Senior
    Work at office
    Relocation

    Agbo

    Raleigh, NC
    3 days ago
  • $115k - $160k

    Job description: The Senior Electrical Engineer oversees the design, analysis, and implementation of electrical systems for a variety of projects, ensuring compliance with industry standards and client requirements. This role leads discipline work on medium to large projects... 
    Senior

    Affinity Executive Search

    Raleigh, NC
    4 days ago
  •  ...competitive pay and benefits.This position is part of the Substation Engineering team located in the Duke Energy Progress (DEP) headquarters in...  ...4 years of relevant engineering experience.Basic Requirements Senior EngineerGraduation from a four-year college or university with... 
    Senior
    Local area
    Remote work
    Visa sponsorship
    Relocation package
    Monday to Friday

    Duke Energy

    Raleigh, NC
    3 days ago
  • Itron, Inc. seeks a Sr. Supply Chain Systems Architect to lead Oracle Fusion SCM configurations and MES integrations in a discrete manufacturing environment. You will drive material management, production planning, and manufacturing execution processes with strong analytics... 
    Senior

    Itron, Inc.

    Raleigh, NC
    4 days ago
  •  ...resilient communities and quality of life. We bring together planners, engineers, architects, construction management staff, environmental,...  ...that connects employees around the world.HDR is looking for a Senior Transit / Rail Engineer to join our Transportation Business... 
    Senior
    Local area

    HDR

    Raleigh, NC
    1 day ago
  • Itron, Inc. is seeking a Sr. Supply Chain Systems Architect to lead Oracle Fusion SCM implementations and MES integrations for discrete manufacturing. The role focuses on material management, production planning, order fulfillment, and inbound/outbound flows, with analytics... 
    Senior

    Itron

    Raleigh, NC
    6 days ago
  • DescriptionThe Senior Substation Engineer will lead the preparation of design deliverables for new and modified high-voltage (13kV to 765kV) electrical power substation projects. The Senior Substation Engineer will work with the project team through the design and construction... 
    Senior
    Work at office

    Burns & McDonnell

    Raleigh, NC
    4 days ago
  • $155.6k - $306.8k

    Position Summary At Deloitte, Forward Deployed Engineers (FDE) don’t just build AI solutions, they help clients turn AI ambition...  ...Recruiting for this role ends on 10/30/2026. Work you’ll do As a Senior ServiceNow FDE, you will work side by side with senior... 
    Senior
    Local area
    Shift work

    Deloitte

    Raleigh, NC
    1 day ago
  •  ...focused on higher education, K-12 schools, infrastructure, and more.As our project backlog continues to grow, we are seeking a Senior Electrical Engineer to join our Healthcare Electrical Department in Raleigh, NC. In this pivotal role, you will provide essential technical... 
    Senior
    Contract work
    For contractors
    Work at office
    Local area

    Dewberry

    Raleigh, NC
    3 days ago
  • DescriptionA Senior Electrical Designer will lead various phases of planning, site evaluations, analytical designs, design documents...  ...diagrams, and relay panel schematics under the direction of the engineer.Incorporate schedules, budgets and project criteria into electrical... 
    Senior

    Burns & McDonnell

    Raleigh, NC
    4 days ago
  •  ...The Senior Electrical Engineer oversees the design, analysis, and implementation of electrical systems for a variety of projects, ensuring compliance with industry standards and client requirements. This role leads discipline work on medium to large projects and could... 
    Senior

    NPAworldwide

    Raleigh, NC
    1 day ago
  •  ...not have to choose between living life and making a living. Live your best life with Merz Aesthetics.A Brief OverviewThe Senior Electrical Engineer will lead the design, development, and analysis of electronic hardware and embedded firmware for both new and existing products... 
    Senior
    Full time

    Merz Pharma

    Raleigh, NC
    16 hours ago
  •  ...Biogen seeks a Senior Engineer I, Manufacturing Sciences to provide SME expertise across end-to-end single-use consumable raw materials from Drug Substance to Drug Product fill. You will collaborate with suppliers, sites, and regulatory teams to ensure materials are fit... 
    Senior

    Biogen

    Raleigh, NC
    4 days ago
  • $168k - $231k

     ...A leading healthcare company is looking for a Senior R&D Manager in Raleigh, NC, to oversee sustaining engineering projects and lead a technical team. The role demands expertise in hardware product sustaining, team building, and project management. Candidates should possess... 
    Senior

    Baxter Healthcare Corporation

    Raleigh, NC
    2 hours ago
  • Job DescriptionDewberry is expanding its Energy Market Sector and seeking a Senior Physical Electrical Engineer to lead the growth of our medium and high voltage substation design practice. This is a unique opportunity to build and mentor a high-performing team while delivering... 
    Senior

    Dewberry

    Raleigh, NC
    4 days ago
  •  ...Senior Traffic EngineerFreese and Nichols is looking for a Senior Traffic Engineer in the Greenville, Columbia, or Raleigh offices. As a Senior Traffic Engineer, you will lead traffic analyses and studies that support transportation planning and design projects across... 
    Senior

    Freese and Nichols

    Raleigh, NC
    16 hours ago
  •  ...owned firm? Wiley|Wilson, with 190+ employee-owners across five offices, is looking for the right person to grow with us!As a Senior Civil Engineer, you'll lead the design of complex land development and infrastructure projects, serving federal government clients. These... 
    Senior
    Local area
    Work from home

    Wiley & Wilson

    Raleigh, NC
    4 days ago
  •  ...JE Dunn Construction is seeking a Senior Project Engineer for a traveling role in its National Healthcare Division. The position involves managing parts of projects, coordinating safety, QA/QC, and procurement, and delivering on-site leadership across assignments nationwide... 
    Senior
    Relocation

    JE Dunn Construction

    Raleigh, NC
    1 day ago

Do you want to receive more vacancies?

Subscribe and receive similar vacancies to Senior MES Engineer. Be the first to apply!