Commercial Supply Chain Manager, Small Molecule

Job Description General Summary The Commercial Supply Chain Manager will support commercial supply chain execution for a late‑stage small molecule program. As Vertex expands its portfolio and advances new therapies toward commercialization, this role will play a key part in monthly supply planning, the S&OP process, planning system setup, inventory management, Long Range Plans (LRP) and cross‑functional supply‑chain coordination. The position is responsible for delivering the monthly supply planning tasks, support in the S&OP process, setting up planning & execution systems and partnering with cross‑functional teams to align material, capacity and operational requirements to support on‑time manufacturing execution and product supply. The role will also support process integration, system testing and continuous improvement efforts to help build a best‑in‑class supply chain. This position reports to the Associate Director, Commercial Supply Chain - Pipeline, within Supply Chain Management and the Biopharmaceutical Sciences and Manufacturing Operations (BSMO) division, and is based at Vertex's corporate headquarters in Boston, MA. Key Duties and Responsibilities Deliver monthly end‑to‑end supply and inventory build plans using Kinaxis Maestro / Rapid Response, taking into consideration supplier capacity, demand uncertainty and overall risk management. Support the commercial and late‑stage small‑molecule program including scenario planning to facilitate data‑driven decisions. The scenario planning includes supply projections, 5+ year forward‑looking assessments of forecast / supply scenarios and inventory planning to support life‑cycle management initiatives. Support implementation, testing and improvement of planning and execution systems functionality to further advance technology and planning processes optimization / efficiency. Serve as planning super‑user for Kinaxis Maestro / Rapid Response. Support the Sales & Operations Planning (S&OP) process to enable robust material and capacity investments including network expansion. Proactively assess risks across the small‑molecule network and develop mitigation plans. Support supply‑chain strategic initiatives such as implementing safety stock for materials, monitoring operational readiness, capacity analysis and integration of different systems requirements. Lead creation and maintenance of master data, including lead times, pricing and approved vendor lists and perform periodic review of master data and ensure alignment with department policies and guidelines. Drive excellence in end‑to‑end operations through management of key supply‑chain KPI’s. Identify operational efficiency and continuous improvement opportunities across the supply chain to deliver a best‑in‑class supply chain. Represent the supply chain on project sub‑teams and task forces, executing supply‑chain production activities with general guidance, building strong relationships with external manufacturing, quality, logistics, finance, commercial and other functions, fostering team culture and building trust with colleagues to deliver uninterrupted supplies to patients. Champion the culture of quality and ensure that all activities and documentation comply with global regulatory requirements. Perform other duties as assigned. Knowledge and Skills 5+ years progressive experience in supply‑chain planning in the pharmaceutical industry. Demonstrated experience in supply planning using Kinaxis Maestro / Rapid Response. Experience managing and navigating a complex global supply‑chain network. Strong analytical and problem‑solving skills, often addressing novel/unusual situations and exercising judgement based on significant technical experience. Proven ability to innovate and implement practical, compliant solutions, work seamlessly across teams and develop excellent partnerships with peers. Demonstrated understanding of the principles and regulations associated with small‑molecule supply‑chain operations. Sense of urgency to deliver quality results in a highly ethical and professional manner. Excellent communication and interpersonal skills with the ability to communicate complex issues and solutions. Demonstrated ability to anticipate different scenarios and provide contingency plans to address potential adversities. Excellent and reliable team player. Demonstrated ability to collaborate with other functional areas, build and sustain trust at all levels of the organization. Experience in Oracle E‑Business Suite Process Manufacturing (OPM) or SAP. Flexibility and versatility as the commercial supply‑chain team and business evolve. Education and Experience Bachelor's degree in a scientific or business discipline. Pay Range $116,200 - $174,200 Disclosure Statement The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job‑related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market‑leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week‑long company shutdown in the summer and the winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation Hybrid‑Eligible or On‑Site Eligible. Flex Eligibility Status In this Hybrid‑Eligible role, you can choose to be designated as: Hybrid: work remotely up to two days per week. On‑Site: work five days per week on‑site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non‑discrimination for all employees and qualified applicants without regard to race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status or any characteristic protected under applicable law. Vertex is an E‑Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at View email address on click.appcast.io. #J-18808-Ljbffr